Discovery and characterization of N-(1,3-dialkyl-1H-indazol-6-yl)-1H-pyrazolo[4,3-b]pyridin-3-amine scaffold as mGlu4 positive allosteric modulators that mitigate CYP1A2 induction liability

Discovery and characterization of N-(1,3-dialkyl-1H-indazol-6-yl)-1H-pyrazolo[4,3-b]pyridin-3-amine scaffold as mGlu4 positive allosteric modulators that mitigate CYP1A2 induction liability

Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 28, Issue 15, 15 August 2018, Pages 2641-2646

Darren W. Engers, Sean R. Bollinger, Julie L. Engers, Joseph D. Panarese, Megan M. Breiner, Alison Gregro, Anna L. Blobaum, Joanne J. Bronson, Yong-Jin Wu, John E. Macor, Alice L. Rodriguez, Rocio Zamorano, P. Jeffrey Conn, Craig W. Lindsley,