دانلود مقالات ISI درباره رابطه ساختار-فعالیت + ترجمه فارسی

Targeting Wnt-driven cancers: Discovery of novel tankyrase inhibitors

Keywords: رابطه ساختار-فعالیت; Tankyrase inhibitors; PARP family; Wnt/β-catenin signaling pathway; Wnt pathway disruption; Wnt-driven cancers; APC; adenomatous polyposis coli gene product; ARTD; ADP-ribosyltransferases; CK1; casein kinase 1; DMPK; drug metabolism and pharmacokinetics;

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2017 سفارش ترجمه

Design, synthesis and biological evaluation of alkylamino biphenylamides as Hsp90 C-terminal inhibitors

Keywords: رابطه ساختار-فعالیت; Heat shock protein 90; Hsp90 C-terminal inhibitors; Alkylamino biphenylamides; Structure-activity relationship; Breast cancer;

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2017 سفارش ترجمه

Design, synthesis, and structure-activity relationship study of halogen containing 2-benzylidene-1-indanone derivatives for inhibition of LPS-stimulated ROS production in RAW 264.7 macrophages

Keywords: رابطه ساختار-فعالیت; Halogen containing 2-benzylidene-1-indanone; Anti-inflammatory agents; Inhibition of ROS production; RAW 264.7 macrophages; Structure-activity relationship;

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2017 سفارش ترجمه

Catalytic asymmetric synthesis of 2,3,3,3-tetrafluoro-2-methyl-1-arylpropan-1-amines as useful building blocks for SAR-studies

Keywords: رابطه ساختار-فعالیت; Fluorinated α-isopropylbenzylamines; Chiral 2,3,3,3-tetrafluoro-2-methyl-1-arylpropan-1-amines; Trifluoromethyl; Fluorine gauche effect; Structure-activity relationship; Cooperative catalysis;

دانلود رایگان متن کامل مقاله ISI 19 صفحه سال انتشار : 2017 سفارش ترجمه

Azide-alkyne cycloaddition towards 1H-1,2,3-triazole-tethered gatifloxacin and isatin conjugates: Design, synthesis and in vitro anti-mycobacterial evaluation

Keywords: رابطه ساختار-فعالیت; Gatifloxacin; Isatin; Triazole; Conjugates; Anti-tuberculosis activity; Anti-mycobacterial activity; Structure-activity relationship;

دانلود رایگان متن کامل مقاله ISI 19 صفحه سال انتشار : 2017 سفارش ترجمه

Discovery of a series of dihydroquinoxalin-2(1H)-ones as selective BET inhibitors from a dual PLK1-BRD4 inhibitor

Keywords: رابطه ساختار-فعالیت; BRD4 inhibitor; Kinase; BI-2536; Dihydroquinoxalin-2(1H)-one; PLK1; Polo-like Kinase 1; JAK2; Janus kinase 2; PTMs; post-translational modifications; KAc; acetylated lysine; BET; Bromodomain and Extra-Terminal; P-TEFb; positive transcription elongation fa

دانلود رایگان متن کامل مقاله ISI 20 صفحه سال انتشار : 2017 سفارش ترجمه

Heterogeneous simplified Maruoka phase-transfer catalyst tethered on poly(styrene-co-acrylamide) microsphere: Structure-activity relationship in enantioselective α-alkylation

Keywords: رابطه ساختار-فعالیت; Simplified Maruoka catalyst; Heterogeneous catalysis; Poly(styrene-co-acrylamide) microsphere; Structure-activity relationship; Asymmetric α-alkylation;

دانلود رایگان متن کامل مقاله ISI 21 صفحه سال انتشار : 2017 سفارش ترجمه

Novel designed VmCT1 analogs with increased antimicrobial activity

Keywords: رابطه ساختار-فعالیت; Antimicrobial peptides; VmCT1; Scorpion venom; Structure-activity relationship;

دانلود رایگان متن کامل مقاله ISI 22 صفحه سال انتشار : 2017 سفارش ترجمه

Calcitonin-typical suppression of osteoclastic activity by amphioxus calcitonin superfamily peptides and insights into the evolutionary conservation and diversity of their structures

Keywords: رابطه ساختار-فعالیت; Calcitonin; Amphioxus; Structure-activity relationship; Alpha-helix; Goldfish scales;

دانلود رایگان متن کامل مقاله ISI 24 صفحه سال انتشار : 2017 سفارش ترجمه

Strategic incorporation of fluorine in the drug discovery of new-generation antitubercular agents targeting bacterial cell division protein FtsZ

Keywords: رابطه ساختار-فعالیت; Mycobacterium tuberculosis; Antibacterial; Fluorine-containing benzimidazoles; FtsZ; Structure-activity relationship; Metabolic and plasma stability; Docking; Molecular modeling;

دانلود رایگان متن کامل مقاله ISI 26 صفحه سال انتشار : 2017 سفارش ترجمه

Computational design and synthesis of novel fluoro-analogs of combretastatins A-4 and A-1

Keywords: رابطه ساختار-فعالیت; Combretastatin A-4 and A-1; Anticancer agent; Vascular disrupting agent; Fluoro-analog; Structure-based drug design; In silico screening; Structure-activity relationship;

دانلود رایگان متن کامل مقاله ISI 26 صفحه سال انتشار : 2017 سفارش ترجمه

Safe approaches for camptothecin delivery: Structural analogues and nanomedicines

Keywords: رابطه ساختار-فعالیت; Camptothecin analogues; Camptothecin nanomedicines; Structure-activity relationship; Stimuli-responsive; Clinical trials;

دانلود رایگان متن کامل مقاله ISI 27 صفحه سال انتشار : 2017 سفارش ترجمه

Synthesis and antibacterial activity studies of 2,4-di substituted furan derivatives

Keywords: رابطه ساختار-فعالیت; Pathogens; Antibacterial activity; Structure-activity relationship; Disubstitiuted furans; Synthesis;

دانلود رایگان متن کامل مقاله ISI 29 صفحه سال انتشار : 2017 سفارش ترجمه

Small differences in structure, a large difference in activity - Comparing a new Ru(II)-3-hydroxyiminoflavanone complex with analogous Ru(II) compounds

Keywords: رابطه ساختار-فعالیت; 1; 3-hydroxyiminoflavanone; 2; cis-dichlorido(3-nitrosoflavone)(3-hydroxyiminoflavanone)-ruthenium(II); 3; cis-dichloridobis(3-imino-2-methoxyflavanone)ruthenium(II); 4; cis-dichloridobis(3-imino-2-ethoxyflavanone)ruthenium(II); APTT; activated partial th

دانلود رایگان متن کامل مقاله ISI 29 صفحه سال انتشار : 2017 سفارش ترجمه

Structure-guided development of covalent TAK1 inhibitors

Keywords: رابطه ساختار-فعالیت; Structure-based design; TAK1 kinase inhibitors; Covalent inhibitors; 2,4-Disubstituted pyrimidine; Structure-activity relationship;

دانلود رایگان متن کامل مقاله ISI 29 صفحه سال انتشار : 2017 سفارش ترجمه

Design, synthesis, anticonvulsant evaluation and docking study of 2-[(6-substituted benzo[d]thiazol-2-ylcarbamoyl)methyl]-1-(4-substituted phenyl)isothioureas

Keywords: رابطه ساختار-فعالیت; Benzothiazoles; Anticonvulsant activity; GABA-A; Toxicity; Molecular docking; Structure-activity relationship;

دانلود رایگان متن کامل مقاله ISI 31 صفحه سال انتشار : 2017 سفارش ترجمه

Biology-oriented drug synthesis (BIODS): In vitro β-glucuronidase inhibitory and in silico studies on 2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl aryl carboxylate derivatives

Keywords: رابطه ساختار-فعالیت; Synthesis; In vitro; β-Glucuronidase; In silico; Structure-activity relationship;

دانلود رایگان متن کامل مقاله ISI 31 صفحه سال انتشار : 2017 سفارش ترجمه

Synthesis and anti-mitotic activity of 6,7-dihydro-4H-isothiazolo[4,5-b]pyridin-5-ones: In vivo and cell-based studies

Keywords: رابطه ساختار-فعالیت; Isothiazoles; Dihydroisothiazolopyridinones; Microtubule destabilization; Sea urchin embryo; Cytotoxicity; CA4P; combretastatin A-4 disodium phosphate; DIP; 6,7-dihydro-4H-isothiazolo[4,5-b]pyridin-5-ones; MDR; multi-drug resistance; Pgp; P-glycoprotein;

دانلود رایگان متن کامل مقاله ISI 32 صفحه سال انتشار : 2017 سفارش ترجمه

Synthesis of hetero annulated isoxazolo-, pyrido- and pyrimido carbazoles: Screened for in vitro antitumor activity and structure activity relationships, a novel 2-amino-4-(3'-bromo-4'-methoxyphenyl)-8-chloro-11H-pyrimido[4,5-a]carbazole as an antitumor

Keywords: رابطه ساختار-فعالیت; Hetero annulated carbazoles; Pyrimidocarbazole; Structure-activity relationship; Cytotoxicity; Fluorescent microscopic analysis;

دانلود رایگان متن کامل مقاله ISI 32 صفحه سال انتشار : 2017 سفارش ترجمه

4-Quinolone hybrids and their antibacterial activities

Keywords: رابطه ساختار-فعالیت; Quinolone; Fluoroquinolone; Hybrids; Antibacterial activity; Structure-activity relationship;

دانلود رایگان متن کامل مقاله ISI 33 صفحه سال انتشار : 2017 سفارش ترجمه

Synthesis and in vitro evaluation of new fluorinated quinoline derivatives with high affinity for PDE5: Towards the development of new PET neuroimaging probes

Keywords: رابطه ساختار-فعالیت; Quinoline; Fluorination; Phosphodiesterase 5; Radiotracer; Positron emission tomography; AD; alzheimer's disease; AllocCl; allyl chloroformate; ATR; attenuated total reflectance; cAMP; cyclic adenosine 3′,5′-monophosphate; cGMP; cyclic guanosine 3′,

دانلود رایگان متن کامل مقاله ISI 36 صفحه سال انتشار : 2017 سفارش ترجمه

Design, synthesis and biological evaluation of thienopyrimidine hydroxamic acid based derivatives as structurally novel histone deacetylase (HDAC) inhibitors

Keywords: رابطه ساختار-فعالیت; HDAC inhibitor; Anti-proliferation; Western blot; Thienopyrimidine; Structure-activity relationship;

دانلود رایگان متن کامل مقاله ISI 37 صفحه سال انتشار : 2017 سفارش ترجمه

New potent biaryl sulfate-based hepatitis C virus inhibitors

Keywords: رابطه ساختار-فعالیت; HCV; NS5A inhibitor; Biaryl sulfate; Structure-activity relationship;

دانلود رایگان متن کامل مقاله ISI 37 صفحه سال انتشار : 2017 سفارش ترجمه

Spider peptide toxin HwTx-IV engineered to bind to lipid membranes has an increased inhibitory potency at human voltage-gated sodium channel hNaV1.7

Keywords: رابطه ساختار-فعالیت; BSA; bovine serum albumin; CHOL; cholesterol; C1P; ceramide-1-phosphate; FLIPRTETRA; fluorescent imaging plate reader; GMT; gating modifier toxin; HBS; HEPES buffered saline; ICK; inhibitory cystine knot; LUV; large unilamellar vesicle; hNaV; human voltag

دانلود رایگان متن کامل مقاله ISI 37 صفحه سال انتشار : 2017 سفارش ترجمه

Novel organophosphorus scaffolds of urease inhibitors obtained by substitution of Morita-Baylis-Hillman adducts with phosphorus nucleophiles

Keywords: رابطه ساختار-فعالیت; Phosphonic and phosphinic acids; Substitution of allyl acetates; Enzyme inhibitors; Structure-activity relationship; Binding mode;

دانلود رایگان متن کامل مقاله ISI 38 صفحه سال انتشار : 2017 سفارش ترجمه

Structure-activity relationship studies of 1,7-diheteroarylhepta-1,4,6-trien-3-ones with two different terminal rings in prostate epithelial cell models

Keywords: رابطه ساختار-فعالیت; 1,7-Diheteroarylhepta-1,4,6-trien-3-one; Antiproliferative activity; Prostate cancer; Structure-activity relationship; Cell apoptosis;

دانلود رایگان متن کامل مقاله ISI 40 صفحه سال انتشار : 2017 سفارش ترجمه

Hydrazinyl arylthiazole based pyridine scaffolds: Synthesis, structural characterization, in vitro α-glucosidase inhibitory activity, and in silico studies

Keywords: رابطه ساختار-فعالیت; Synthesis; Pyridine; Hydrazinyl arylthiazole; α-Glucosidase; In vitro; Structure-activity relationship; Molecular docking;

دانلود رایگان متن کامل مقاله ISI 42 صفحه سال انتشار : 2017 سفارش ترجمه

Fucosylated chondroitin sulfate oligosaccharides exert anticoagulant activity by targeting at intrinsic tenase complex with low FXII activation: Importance of sulfation pattern and molecular size

Keywords: رابطه ساختار-فعالیت; Sea cucumber; Fucosylated chondroitin sulfate; Depolymerization; Anticoagulant; Structure-activity relationship;

دانلود رایگان متن کامل مقاله ISI 42 صفحه سال انتشار : 2017 سفارش ترجمه

Structural Analysis of Heparin-Derived 3-O-Sulfated Tetrasaccharides: Antithrombin Binding Site Variants

Keywords: رابطه ساختار-فعالیت; antithrombin-binding site; heparin-derived tetrasaccharides; anticoagulant activity; heparin lyase; structure-activity relationship; AT; antithrombin III; UA; uronic acid; IdoA; iduronic acid; GlcA; β-D-glucuronic acid; GlcN; α-d-glucosamine; STs; sulfo

دانلود رایگان متن کامل مقاله ISI 43 صفحه سال انتشار : 2017 سفارش ترجمه

The replacement of the 2-methoxy substituent of N-((6,6-diphenyl-1,4-dioxan-2-yl)methyl)-2-(2-methoxyphenoxy)ethan-1-amine improves the selectivity for 5-HT1A receptor over α1-adrenoceptor and D2-like receptor subtypes

Keywords: رابطه ساختار-فعالیت; 5-HT1A receptor; α1-Adrenoceptor subtypes; D2-like receptor subtypes; Selective 5-HT1A receptor agonists; Docking studies; Anxiolytic effect; 5-HT; 5-hydroxytriptamine; GPCR; G protein-coupled receptor; TM; transmembrane; ARs; adrenoceptors; SAR; structu

دانلود رایگان متن کامل مقاله ISI 44 صفحه سال انتشار : 2017 سفارش ترجمه

Molecular insights into allosteric modulation of Class C G protein-coupled receptors

Keywords: رابطه ساختار-فعالیت; GABAB; γ-aminobutyric acid receptor B; BMD; bone mass and density; CaSR; calcium-sensing receptor; CHO; Chinese hamster ovary; CRD; cysteine-rich domain; ER; endoplasmic reticulum; Ca2+o; extracellular calcium; pERK1/2; extracellular signal-regulated kin

دانلود رایگان متن کامل مقاله ISI 52 صفحه سال انتشار : 2017 سفارش ترجمه

Modulating hydrogen-bond basicity within the context of protein-ligand binding: A case study with thrombin inhibitors that reveals a dominating role for desolvation

Keywords: رابطه ساختار-فعالیت; Thrombin; Protein-ligand binding; Desolvation; Bioisosterism; Hydrogen bond; Cooperativity; Nonadditivity; B3LYP/6-31G∗; Bn; benzyl; tert-Bu; tertiary butyl; DCM; dichloromethane; DIEA; diisopropylethylamine; DMF; dimethylformamide; EDCI.HCl; 1-ethyl-3-

دانلود رایگان متن کامل مقاله ISI 53 صفحه سال انتشار : 2017 سفارش ترجمه

Novel indolizino[8,7-b]indole hybrids as anti-small cell lung cancer agents: Regioselective modulation of topoisomerase II inhibitory and DNA crosslinking activities

Keywords: رابطه ساختار-فعالیت; Anti-SCLC hybrids; β-carboline; bis(hydroxymethyl)pyrrole; indolizino[8,7-b]indole; DNA cross-linking; Topoisomerase inhibition; Ac2O; acetic anhydride; ACN; acetonitrile; CCRF-CEM; human lymphoblastic leukemia; CCRF-CEM/VBL; vinblastine-resistant CCRF-C

دانلود رایگان متن کامل مقاله ISI 56 صفحه سال انتشار : 2017 سفارش ترجمه

Discovery, structure-activity relationship studies, and anti-nociceptive effects of N-(1,2,3,4-tetrahydro-1-isoquinolinylmethyl)benzamides as novel opioid receptor agonists

Keywords: رابطه ساختار-فعالیت; μ-opioid receptor agonist; κ-opioid receptor agonist; Structure-activity relationship; Blood-brain barrier; Penetration; Anti-nociceptive effects; Tail-flick test;

دانلود رایگان متن کامل مقاله ISI 60 صفحه سال انتشار : 2017 سفارش ترجمه

Synthesis, anti-proliferative activity, SAR study, and preliminary in vivo toxicity study of substituted N,N′-bis(arylmethyl)benzimidazolium salts against a panel of non-small cell lung cancer cell lines

Keywords: رابطه ساختار-فعالیت; NCI; National Cancer Institute; IC50; inhibitory concentration 50%; NSCLC; non-small cell lung cancer; MTT; 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; SAR; structure-activity relationship; GI50; growth inhibition 50%; TGI; total growth

دانلود رایگان متن کامل مقاله ISI 66 صفحه سال انتشار : 2017 سفارش ترجمه

Traditional uses, phytochemistry, pharmacology and toxicology of the genus Cimicifuga: A review

Keywords: رابطه ساختار-فعالیت; TCM; traditional Chinese medicine; TLC; thin-layer chromatography; PCA; principal component analysis; XMT; brand name of the alcoholic extract of C. foetida; FST; forced swimming test; TST; tail suspension test; MeOH; methanol; i-PrOH; isopropanolic; CH;

دانلود رایگان متن کامل مقاله ISI 71 صفحه سال انتشار : 2017 سفارش ترجمه

Discovery and structure-activity relationship studies of 2-benzylidene-2,3-dihydro-1H-inden-1-one and benzofuran-3(2H)-one derivatives as a novel class of potential therapeutics for inflammatory bowel disease

Keywords: رابطه ساختار-فعالیت; Inflammatory bowel disease; 2-Benzylidene-2,3-dihydro-1H-inden-1-one; Benzofuran-3(2H)-one; TNF-α; Structure-activity relationship;

دانلود رایگان متن کامل مقاله ISI 78 صفحه سال انتشار : 2017 سفارش ترجمه

Oleanane-, ursane-, and quinone methide friedelane-type triterpenoid derivatives: Recent advances in cancer treatment

Keywords: رابطه ساختار-فعالیت; Pentacyclic triterpenoids; Cancer; Semisynthetic derivatives; Structure-activity relationship;

دانلود رایگان متن کامل مقاله ISI 82 صفحه سال انتشار : 2017 سفارش ترجمه

Prenylflavone derivatives from the seeds of Psoralea corylifolia exhibited PPAR-γ agonist activity

Keywords: رابطه ساختار-فعالیت; Psoralea corylifolia; Prenylflavone; PPAR-γ; Structure-activity relationship; Diabetes;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2016 سفارش ترجمه

Discovery of novel pyrrolidineoxy-substituted heteroaromatics as potent and selective PI3K delta inhibitors with improved physicochemical properties

Keywords: رابطه ساختار-فعالیت; Phosphoinositide-3-kinase delta inhibitor; PI3Kδ inhibitor; Structure-activity relationship; Physicochemical properties; Lipophilicity;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2016 سفارش ترجمه

Bioactive gentixanthone and gentichromone from the whole plants of Gentianella acuta (Michx.) Hulten

Keywords: رابطه ساختار-فعالیت; Gentianella acuta (Michx.) Hulten; Xanthone; Chromone; Intestine motility; Structure-activity relationship

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2016 سفارش ترجمه

Full length articleStructure-activity relationships of fluorinated dendrimers in DNA and siRNA delivery

Keywords: رابطه ساختار-فعالیت; Fluorination; Dendrimer; Gene delivery; siRNA; Structure-activity relationship;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

Structure-activity relationship study between baicalein and wogonin by spectrometry, molecular docking and microcalorimetry

Keywords: رابطه ساختار-فعالیت; Baicalein; Wogonin; Structure-activity relationship; Antioxidant activity; Antibacterial activity

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

Synthesis, molecular docking and α-glucosidase inhibition of 5-aryl-2-(6′-nitrobenzofuran-2′-yl)-1,3,4-oxadiazoles

Keywords: رابطه ساختار-فعالیت; 1,3,4-Oxadiazole; α-Glucosidase inhibition; Structure-activity relationship; Molecular docking;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

Determination of genotoxic potential by comparison of structurally related azo dyes using DNA repair-deficient DT40 mutant panels

Keywords: رابطه ساختار-فعالیت; DNA damage; Genotoxicity; Sudan I; Structure-activity relationship; SAR;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

Dihydro-β-agarofuran sesquiterpenes from celastraceae species as anti-tumour-promoting agents: Structure-activity relationship

Keywords: رابطه ساختار-فعالیت; Maytenus chiapensis; Zinowiewia costaricencis; Dihydro-β-agarofuran sesquiterpenes; Epstein-Barr virus; Structure-activity relationship; Anti-tumour promoting agent

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

Synthesis and evaluation of in vitro antiproliferative activity of new ethyl 3-(arylethynyl)quinoxaline-2-carboxylate and pyrido[4,3-b]quinoxalin-1(2H)-one derivatives

Keywords: رابطه ساختار-فعالیت; Quinoxaline; Organic chemistry; Antitumor activity; Structure-activity relationship;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

Syntheses of new 3-thiazolyl coumarin derivatives, in vitro α-glucosidase inhibitory activity, and molecular modeling studies

Keywords: رابطه ساختار-فعالیت; Synthesis; 3-Thiazolylcoumarin; α-Glucosidase; Structure-activity relationship; Docking studies; Diabetic complications; Acarbose

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

Insights into the structure activity relationship of mPGES-1 inhibitors: Hints for better inhibitor design

Keywords: رابطه ساختار-فعالیت; mPGES-1; Inflammation; Arthritis; Osteoarthritis; Molecular docking; Structure-activity relationship

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

Construction of ultrafine and stable PtFe nano-alloy with ultra-low Pt loading for complete removal of CO in PROX at room temperature

Keywords: رابطه ساختار-فعالیت; Ultrafine PtFe alloy; Structure-activity relationship; Preferential oxidation of CO; Ultra-low Pt loading

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه