دانلود مقالات ISI درباره رابطه فعالیت ساختاری + ترجمه فارسی

Kinase domain inhibition of leucine rich repeat kinase 2 (LRRK2) using a [1,2,4]triazolo[4,3-b]pyridazine scaffold

Keywords: رابطه فعالیت ساختاری; AD; Alzheimer's disease; ANK; ankyrin repeat domain; ARM; armadillo repeat domain; AUC; area under the curve; BA; brain availability; BBB; blood brain barrier; BCRP; breast cancer related protein; BI; brain impairment; CSD; Cambridge Structural Database

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Carbonic anhydrase inhibitors: Synthesis and inhibition of the human carbonic anhydrase isoforms I, II, IX and XII with benzene sulfonamides incorporating 4- and 3-nitrophthalimide moieties

Keywords: رابطه فعالیت ساختاری; CA; carbonic anhydrase; hCA; human carbonic anhydrase; CAI; carbonic anhydrase inhibitor; SAR; structure-activity relationship; Zn; zinc; AZM; acetazolamide; MZA; methazolamide; EZA; ethoxzolamide; DCP; dibromophenamide; DZA; dorzolamide; BRZ; brinzolam

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

Synthesis and structure activity relationship of imidazo[1,2-a]pyridine-8-carboxamides as a novel antimycobacterial lead series

Keywords: رابطه فعالیت ساختاری; Antimycobacterial activity; Whole cell screening; Structure activity relationship; Physicochemical properties;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

N-Alkylated 2,3,3-trimethylindolenines and 2-methylbenzothiazoles. Potential lead compounds in the fight against Saccharomyces cerevisiae infections

Keywords: رابطه فعالیت ساختاری; Antifungal; Drug design; 2-Methylbenzothiazole; Structure activity relationship; 2,3,3-Trimethylindolenine; Yeast;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Potency optimization of Huwentoxin-IV on hNav1.7: A neurotoxin TTX-S sodium-channel antagonist from the venom of the Chinese bird-eating spider Selenocosmia huwena

Keywords: رابطه فعالیت ساختاری; ACF; animal-component free; BSA; bovine serum albumin; CaCl2; calcium chloride; CD; circular dichroism spectroscopy; CHO; Chinese hamster ovary; CNS; central nervous system; CO2; carbon dioxide; CsF; cesium fluoride; CsOH; cesium hydroxide; DIC; diisoprop

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Epothilone D and its 9-Methyl analogues: Combinatorial syntheses, conformation, and biological activities

Keywords: رابطه فعالیت ساختاری; Epothilone; Analogues; Total synthesis; Structure activity relationship; Bioactivity;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2013 سفارش ترجمه

Synthesis and SAR studies of 5-(pyridin-4-yl)-1,3,4-thiadiazol-2-amine derivatives as potent inhibitors of Bloom helicase

Keywords: رابطه فعالیت ساختاری; BLM; Bloom helicase; SAR; structure activity relationship; HTS; high throughput screen; ADME; absorption, distribution, metabolism and excretion; MLM; mouse liver microsomes; NADPH; nicotinamide adenine dinucleotide phosphate; PBS; phosphate buffered sali

دانلود رایگان متن کامل مقاله ISI 21 صفحه سال انتشار : 2013 سفارش ترجمه

Catalytic-site conformational equilibrium in nerve-agent adducts of acetylcholinesterase: Possible implications for the HI-6 antidote substrate specificity

Keywords: رابطه فعالیت ساختاری; DFP; diisopropylfluorophosphate; tabun; ethyl N-dimethylphosphoramidocyanidate; soman; pinacolylmethylphosphonofluoridate; sarin; isopropylmethylphosphono- fluoridate; cyclosarin; cyclohexylmethylphosphonofluoridate; VX; O-ethyl S-[2-(diisopropylamino)eth

دانلود رایگان متن کامل مقاله ISI 30 صفحه سال انتشار : 2013 سفارش ترجمه

ReviewThe potential health benefit of polyisoprenylated benzophenones from Garcinia and related genera: Ethnobotanical and therapeutic importance

Keywords: رابطه فعالیت ساختاری; Garcinia; Polyisoprenylated benzophenones; Ethnobotany; Structure activity relationship; Biological activity; Biosynthesis;

دانلود رایگان متن کامل مقاله ISI 40 صفحه سال انتشار : 2013 سفارش ترجمه

Structure activity relationship studies of tricyclic bispyran sulfone γ-secretase inhibitors

Keywords: رابطه فعالیت ساختاری; Alzheimer’s disease; γ-Secretase inhibitor; Structure activity relationship; Sulfone

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Arrayed antibody library technology for therapeutic biologic discovery

Keywords: رابطه فعالیت ساختاری; CDR; complementary determining region; mAb; monoclonal antibody; V; variable; D; diversity; J; joining; GPCR; G-protein coupled receptor; CVB; culture vessel block; LIMS; laboratory information management system; Fab; fragment antigen-binding; SAR; struct

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Exploring DNA binding properties and biological activities of dihydropyrimidinones derivatives

Keywords: رابطه فعالیت ساختاری; DNA binding; Spectroscopy; Viscosity; Isothermal titration calorimetry; Structure activity relationship

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

New insight into adenosine receptors selectivity derived from a novel series of [5-substituted-4-phenyl-1,3-thiazol-2-yl] benzamides and furamides

Keywords: رابطه فعالیت ساختاری; 2-Aminothiazole; Adenosine receptors; Selectivity profile; Structure activity relationship; Receptor models; Molecular docking; Membrane molecular dynamics

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2013 سفارش ترجمه

Sulphonamides: Deserving class as MMP inhibitors?

Keywords: رابطه فعالیت ساختاری; Cancer; CGS-27023A; MMP; MMPI; Structure activity relationship; Sulphonamides

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2013 سفارش ترجمه

The structure activity relationship of non-dissolved redox mediators during azo dye bio-decolorization processes

Keywords: رابطه فعالیت ساختاری; Structure activity relationship; Non-dissolved; Redox mediators; Decolorization;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه

The design, synthesis, in silico ADME profiling, antiplasmodial and antimycobacterial evaluation of new arylamino quinoline derivatives

Keywords: رابطه فعالیت ساختاری; Antiplasmodial; Antimycobacterial; Arylamino quinoline tetrazoles; Physico-chemical properties; LGCCUMAZYNMYQJ-UHFFFAOYSA-N; ASBQKDGGVSELGK-UHFFFAOYSA-N; ULKYZCWFSKRIAW-UHFFFAOYSA-N; AWAMGPBRYIMAJY-UHFFFAOYSA-N; SZMJVGJCALVYFM-UHFFFAOYSA-N; NUXYBKNVYZESNU

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Benzimidazole inhibitors of the protein kinase CHK2: Clarification of the binding mode by flexible side chain docking and protein-ligand crystallography

Keywords: رابطه فعالیت ساختاری; ADP; adenosine diphosphate; ATM; ataxia telangiectasia mutated; ATP; adenosine triphosphate; CHK2; checkpoint kinase 2; GOLD; genetic optimisation for ligand docking; GST; glutathione S-transferase; KD; kinase domain; MOE; molecular operating environment;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

P(HPMA)-block-P(LA) copolymers in paclitaxel formulations: Polylactide stereochemistry controls micellization, cellular uptake kinetics, intracellular localization and drug efficiency

Keywords: رابطه فعالیت ساختاری; Poly(N-(2-hydroxypropyl)-methacrylamide; HPMA block copolymers; RAFT polymerization; Structure activity relationship; Polylactide block copolymers; Tacticity

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2012 سفارش ترجمه

Mapping pilicide anti-virulence effect in Escherichia coli, a comprehensive structure-activity study

Keywords: رابطه فعالیت ساختاری; SAR; structure activity relationship; QSAR; quantitative structure activity relationship; PLS; partial least squares; OPLS-DA; orthogonal projections to latent structures discriminant analysis; UTI; urinary tract infection; SMD; statistical molecular desi

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2012 سفارش ترجمه

Structure activity relationship analysis of phenolic acid phenethyl esters on oral and human breast cancers: The grey GM(0, N) approach

Keywords: رابطه فعالیت ساختاری; Grey theory; Phenolic acid phenethyl esters; Cancer cell; Structure activity relationship

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Design, synthesis, and biological evaluation of N-acetyl-S-(p-chlorophenylcarbamoyl)cysteine and its analogs as a novel class of anticancer agents

Keywords: رابطه فعالیت ساختاری; TFA; trifluoroacetic acid; BSA; bovine serum albumin; FBS; fetal bovine serum; DMSO; dimethyl sulfoxide; DPBS; Dulbecco's phosphate buffered saline; EWG; electron withdrawing group; EDG; electron donating group; HPLC; high performance liquid chromatogra

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

Improvement of the Cramer classification for oral exposure using the database TTC RepDose - A strategy description

Keywords: رابطه فعالیت ساختاری; TTC concept; Threshold of toxicological concern; Oral exposure; Refinement; Risk assessment; RepDose; Database; Toxicology; Cramer classification; Structure activity relationship; SAR;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2011 سفارش ترجمه

Synthesis and in vitro antimicrobial evaluation of novel fluoroquinolone derivatives

Keywords: رابطه فعالیت ساختاری; Fluoroquinolones; Antibacterial; Antifungal; Structure activity relationship

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2010 سفارش ترجمه

In vitro mammalian cytotoxicological study of PAMAM dendrimers – Towards quantitative structure activity relationships

Keywords: رابطه فعالیت ساختاری; Polyamidoamine dendrimers; Mammalian cytotoxicity; Particle size; Zeta potential; Media interaction; Structure activity relationship

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2010 سفارش ترجمه

Structure activity relationship studies of imidazo[1,2-a]pyrazine derivatives against cancer cell lines

Keywords: رابطه فعالیت ساختاری; Inhibitor design; Synthesis; Imidazo[1,2-a]pyrazine; Anticancer activity; Structure activity relationship

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2010 سفارش ترجمه

Synthesis and structure activity relationship studies of novel Staphylococcus aureus Sortase A inhibitors

Keywords: رابطه فعالیت ساختاری; Staphylococcus aureus; Sortase; Inhibitor; Antibacterial; Structure activity relationship; SynthesisDabsyl, 4-(4-Dimethylaminophenylazo)-benzenesulfonyl; DIBAL, Diisobutylaluminum hydride; DMAP, N,N-dimethylaminopyridine; DMF, N,N-Dimethylformamide; EDAC,

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2010 سفارش ترجمه

Induction of cell cycle arrest in human MCF-7 breast cancer cells by cis-stilbene derivatives related to VIOXX®

Keywords: رابطه فعالیت ساختاری; Breast cancer; Chemoprevention; Cell cycle; Stilbene derivatives; Structure activity relationship;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2009 سفارش ترجمه

The impact of nitrogen mobility on the activity of zirconium oxynitride catalysts for ammonia decomposition

Keywords: رابطه فعالیت ساختاری; Ammonia decomposition; Zirconium oxynitrides; Heterogeneous catalysis; Structure activity relationship; Nitrogen conductivity

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2007 سفارش ترجمه

Reduction in vegetative growth of the water mold Saprolegnia parasitica (Coker) by humic substance of different qualities

Keywords: رابطه فعالیت ساختاری; Humic substances; Fungistatic effects; Structure activity relationship; Water mold

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2007 سفارش ترجمه

Dopamine D3 receptor ligands—Recent advances in the control of subtype selectivity and intrinsic activity

Keywords: رابطه فعالیت ساختاری; Dopamine D3 receptor; Agonist; Antagonist; Structure activity relationship; Rational drug discovery; G protein-coupled receptor

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2007 سفارش ترجمه

Synthesis and cytotoxicity of novel isomeric C-seco limonoids

Keywords: رابطه فعالیت ساختاری; C-seco limonoids; Isomerisation; Cytotoxicity; Structure activity relationship

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2006 سفارش ترجمه

Inverse agonism or neutral antagonism at G-protein coupled receptors: A medicinal chemistry challenge worth pursuing?

Keywords: رابطه فعالیت ساختاری; Inverse agonist; Neutral antagonist; Medicinal chemistry; Structure activity relationship;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2006 سفارش ترجمه

Novel parent structures for inhibitors of the murine GABA transporters mGAT3 and mGAT4

Keywords: رابطه فعالیت ساختاری; Murine GABA transporter (mGAT1-4); GABA (γ-aminobutyric acid) uptake; Structure activity relationship; Subtype selectivity;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2005 سفارش ترجمه

Radioligand binding studies of caloporoside and novel congeners with contrasting effects upon [35S] TBPS binding to the mammalian GABAA receptor

Keywords: رابطه فعالیت ساختاری; GABA; γ-aminobutyric acid; TBPS; t-butylbicyclophosphoorothionate; SAR; structure activity relationship; TBOB; t-butylbicycloorthobenzoate; DMSO; dimethylsulphoxide; GABAA receptor; Allosteric modulator; TBPS; SAR; Channel site; Antagonist; β-Linkage; S

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2005 سفارش ترجمه

High throughput P450 inhibition screens in early drug discovery

Keywords: رابطه فعالیت ساختاری; Drug Discovery; Biotechnology; Pharmaceutical Science; Cytochromes P450; CYP450 inhibition; drug-drug interactions; high throughput in vitro assays; robotics and automation; structure activity relationship;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2005 سفارش ترجمه

Screening of Bitterness-Suppressing Agents for Quinine: The Use of Molecularly Imprinted Polymers

Keywords: رابطه فعالیت ساختاری; NMR; molecular modeling; HPLC; receptor; structure activity relationship;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2005 سفارش ترجمه