Keywords: AAN; aristolochic acid nephropathy; ADME; absorption, distribution, metabolism and excretion; CYT P450; cytochrome P450; DPP-IV; dipeptidyl peptidase IV; GLP1; glucagon like peptide 1; GLUT4; glucose transporter 4; GSH; glutathione; GST; glutathione-S-tra
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Keywords: Ach; acetylcholine; AchE; acetylcholine esterease; ACTH; adrenocorticotrophic hormone; ADHD; attention deficit/hyperactivity disorder; AIDS; autoimmune deficiency syndrome; AMSH; alpha-melanocyte-stimulating hormone; BAM; bovine adrenal medulla peptide; B
Keywords: T2D; type 2 diabetes; MSCs; mesenchymal stem cells; T1D; type 1 diabetes; BM-MSCs; bone-marrow-derived MSC; STZ; streptozocin; OGTTs; oral glucose tolerance tests; IPITTs; intraperitoneal insulin tolerance tests; Bone marrow; Mesenchymal stem cells; Type
Keywords: ROS; reactive oxygen species; DMSO; dimethyl sulphoxide; STZ; streptozotocin; HbAlc; glycosylated hemoglobin; TBARS; thiobarbituric acid reactive substances; SOD; superoxide dismutase; CAT; catalase; GPx; glutathione peroxidase; GST; glutathione S transfe
Keywords: Aβ; amyloid β; AD; Alzheimer's disease; APP; amyloid precursor protein; ERK1/2; extracellular signal-regulated kinases; H2S; hydrogen sulfide; JNK; c-jun N-terminal kinases; MAPK; mitogen-activated protein kinases; MDA; malondialdehyde; NaHS; sodium h
Keywords: DE; diabetic encephalopathy; DM; diabetes mellitus; TCM; traditional Chinese medicine; LWDHD; Liuwei Dihuang decoction; STZ; streptozotocin; AChE; acetylcholinesterase; ChAT; choline acetyltransferase; AD; Alzheimer's disease; IGF-1; insulin-like growth f
Keywords: Apoptosis; Cardiomyocyte; Coenzyme Q10; Diabetes; Diastolic function; Fibrosis; Hypertrophy; Inflammation; Superoxide; Free radicals; ACE-I; angiotensin-converting-enzyme inhibitor; ANP; atrial natriuretic peptide; AoSBP; aortic systolic blood pressure; B
Keywords: Catharanthus roseus; Catharanthus roseus (L). Don; GSIS; glucose-stimulated insulin secretion; HFD; high-fat diet; STZ; streptozotocin; OGTT; oral glucose tolerance test; HbA1c; glycated hemoglobin; TG; plasma triglyceride; TEA; tetraethylammonium chlorid
Keywords: SOD; superoxide dismutase; GPx; glutathione peroxidases; CAT; catalase; GSH; reduced glutathione; GSSG; oxidized glutathione; GST; glutathione S-transferase; GR; glutathione reductase; mtDNA; mitochondrial DNA; DOX; doxorubicin; APAP; acetaminophen; NAPQI
Keywords: Inositol; Insulin resistance; Diabetes; Polycystic ovary syndrome; Metabolic syndrome; Diabetic neuropathy; AC; adenylyl cyclase; ACC; acetyl-coenzyme A carboxylase; AGEs; advanced glycation end products; AMP; adenosine monophosphate; cAMP; cyclic AMP; AM
Keywords: 20-HETE; 20-hydroxyeicosatetraenoic acid; Ang-II; angiotensin II; AP-1; activator protein 1; ARIC; Atherosclerosis Risk in Communities; ATF-6; activating transcription factor-6; CAC; coronary artery calcification; CARDIA; Coronary Artery Risk Development
Post-stroke neovascularization and functional outcomes differ in diabetes depending on severity of injury and sex: Potential link to hemorrhagic transformation
Keywords: Diabetes; Ischemic Stroke; Hemorrhagic Transformation; Female; Neurovascular Injury; Vascular Cognitive Impairment/Dementia; GK; Goto-Kakizaki; HFD; high fat diet; STZ; streptozotocin; MCAO; middle cerebral artery occlusion; HT; hemorrhagic transformation
Overexpression of ST5, an activator of Ras, has no effect on β-cell proliferation in adult mice
Keywords: Diabetes; β-cell proliferation; ST5 (Suppression Of Tumorigenicity 5); Ras/ERK signaling; ST5; Suppression of Tumorigenicity 5; GEF; Guanine Nucleotide Exchange Factor; ST5 OE; ST5-overexpressing; STZ; streptozotocin; MODY; Maturity Onset Diabetes of the
IL-33 receptor ST2 deficiency attenuates renal ischaemia-reperfusion injury in euglycaemic, but not streptozotocin-induced hyperglycaemic mice
Keywords: Acute tubular necrosis; Diabetic nephropathy; Hyperglycaemia; IL-33/ST2; Inflammation; Renal ischaemia-reperfusion; AKI; acute kidney injury; BMI; body mass index; BUN; blood urea nitrogen; GFR; glomerular filtration rate; IRI; ischemia-reperfusion inju
Naringenin exhibits the protective effect on cardiac hypertrophy via EETs-PPARs activation in streptozocin-induced diabetic mice
Keywords: Naringenin; Diabetes; Cardiac hypertrophy; PPARs; EETs; CYP2J3; AA; arachidonic acid; ANF; atrial natriuretic factor; BW; body weight; CVF; collagen volume fraction; CYP450; cytochrome P450; DCM; diabetic cardiomyopathy; DHM; diabetic cardiac hypertrophy
Novel approaches in the treatment of diabetic cardiomyopathy
Keywords: ACE; angiotensin convertase enzyme; ACEi; angiotensin convertase enzyme inhibitor; ADP; adenosine di phosphate; AGE; advanced glycation end products; AM; adrenomedullin; AMP; adenosine mono phosphate; ARB; angiotensin receptor blocker; ATP; adenosine tri
Effect of yerba mate (Ilex paraguariensis) extract on the metabolism of diabetic rats
Keywords: C group; Control group; CM group; Control with treatment group; D group; diabetes group; DM group; diabetes with treatment group; STZ; streptozotocin; RAT; retroperitoneal adipose tissue; EAT; epidydimal adipose tissue; SM; soleus muscle; L; liver; 14C; c
CREB1 functional polymorphisms modulating promoter transcriptional activity are associated with type 2 diabetes mellitus risk in Chinese population
Keywords: CREB1; cAMP responsive element binding protein 1; T2D; type 2 diabetes mellitus; ZDF; Zucker diabetic fatty; STZ; streptozotocin; SNP; single nucleotide polymorphism; GWAS; genome-wide association study; OGTT; oral glucose tolerance test; aCRS-RFLP; ampli
Down-regulation of microRNA-21 reduces inflammation and podocyte apoptosis in diabetic nephropathy by relieving the repression of TIMP3 expression
Keywords: DN; diabetic nephropathy; HG; high glucose; STZ; streptozotocin; PAS; periodic acid schiff; TIMP3; tissue inhibitors of metalloproteinase 3; MMPs; matrix metalloproteinases; miRNAs; microRNAs; ACE2; angiotensin-converting enzyme 2; TNF-α; tumor necrosis
Renal protective effect of SGLT2 inhibitor dapagliflozin alone and in combination with irbesartan in a rat model of diabetic nephropathy
Keywords: ABP; arterial blood pressure; ACE; angiotensin converting enzyme; AGEs; advanced glycation end products; ARB; angiotensin receptor blocker; BUN; blood urea nitrogen; Cr Cl; creatinine clearance; DN; diabetic nephropathy; GSH-Px; glutathione peroxidase; Hb
Possible therapeutic potential of berberine in the treatment of STZ plus HFD-induced diabetic osteoporosis
Keywords: ROS; Reactive oxygen species; PTP1B; protein tyrosine phosphatase 1b; AMPK; adenosine monophosphate activated protein kinase; gluT1; glucose transporters; RANKL; Receptor activator of nuclear factor kappa-B ligand; NF-kB; NF-kappaB; BMSCs; bone marrow mes
Herb-drug interaction of Nisha Amalaki and Curcuminoids with metformin in normal and diabetic condition: A disease system approach
Keywords: NA; Nisha Amalaki; CE; Curcuminoids; MET; metformin; DDI; drug-drug interactions; HDI; herb-drug interactions; CYPs; cytochrome p450 isoenzymes; IS; internal standard; MWR; Male Wistar rats; STZ; streptozotocin; MNC; mononuclear cells; OCT; organic cation
Inotodiol suppresses proliferation of breast cancer in rat model of type 2 diabetes mellitus via downregulation of β-catenin signaling
Keywords: INO; inotodiol; STZ; streptazotocin; DMBA; 7,12-dimethylbenz(a)anthracene; OGTT; oral glucose tolerance test; PCNA; proliferating cell nuclear antigen; TUNEL; terminal deoxynucleotidyl transferase (TdT) dUTP nick-end labeling; SOD; superoxide dismutase; G
Evaluating STZ-Induced Impaired Wound Healing in Rats
Keywords: DM; diabetes mellitus; STZ; streptozotocin;
Long Non-coding RNA BC168687 is Involved in TRPV1-mediated Diabetic Neuropathic Pain in Rats
Keywords: DNP; diabetic neuropathic pain; DRG; dorsal root ganglia; FPG; fasting plasma glucose; lncRNAs; long noncoding RNAs; MAPK; mitogen-activated protein kinase; MWT; mechanical withdrawal thresholds; PBS; phosphate buffer saline; PNS; peripheral nervous syste
Preclinical assessment of utility of M6S for multimodal acute and chronic pain treatment in diabetic neuropathy
Keywords: δ-OR; delta-opioid receptor; DPN; diabetic polyneuropathy; ED50; half-effective drug dose; Emax; maximally effective drug dose; HPT; hot plate threshold; κ-OR; kappa opioid receptor; M6S; morphine-6-O-sulfate; MPE; maximum possible effect; μ-OR; mu-opi
Resveratrol attenuates testicular apoptosis in type 1 diabetic mice: Role of Akt-mediated Nrf2 activation and p62-dependent Keap1 degradation
Keywords: RSV; resveratrol; STZ; streptozotocin; ROS; reactive oxygen species; RNS; reactive nitrogen species; SOD; superoxide dismutase; Nrf2; nuclear factor erythroid 2-related factor 2; Keap1; kelch-like ECH-associated protein 1; NQO-1; NAD(P)H:quinone oxidoredu
Synthesis, molecular modelling studies and ADME prediction of benzothiazole clubbed oxadiazole-Mannich bases, and evaluation of their anti-diabetic activity through in vivo model
Keywords: Diazole; Hyperglycaemic; Heterocyclic; PPAR; Synthesis; STZ;
Treatment with crocin improves cardiac dysfunction by normalizing autophagy and inhibiting apoptosis in STZ-induced diabetic cardiomyopathy
Keywords: Diabetes; Crocin; Cardiac function; Autophagy; Apoptosis; Heat shock response; DM; diabetes mellitus; STZ; streptozotocin; AMPK; adenosine monophosphate-activated protein kinase; EF; Ejection Fraction; FS; Fractional Shortening; IVSs,d; systolic and diast
Insulin is a potential antioxidant for diabetes-associated cognitive decline via regulating Nrf2 dependent antioxidant enzymes
Keywords: ARE; Nrf2-antioxidant responsive element; CAT; catalase; DMEM; Dulbecco's Modified Eagle's Medium; DMSO; dimethyl sulfoxide; DCFH-DA; 2',7'-dichlorodihydro-fluorescence diacetate; FBS; fetal bovine serum; GSH-Px; glutathione peroxidase; H2O2; hydr
The beneficial effects of Zn on Akt-mediated insulin and cell survival signaling pathways in diabetes
Keywords: Akt2-KO; Akt2 gene deletion; CHO; Chinese hamster ovary; DM; diabetes mellitus; EGF; epidermal growth factor; EGFR; epidermal growth factor receptor; ER; endoplasmic reticulum; GLUT4; glucose transporter type-4; GS; glycogen synthase; GSK-3; glycogen synt
N-acetylcysteine attenuates systemic platelet activation and cerebral vessel thrombosis in diabetes
Keywords: ACD; citrate-dextrose solution; APC; activated protein C; ATIII; antithrombin III; FITC; fluorescein isothiocyanate; Glo; glyoxalase; GPx-1; glutathione peroxidase-1; GSH; glutathione; GSSG; glutathione disulfide; MG; methylglyoxal; NAC; N-acetylcysteine;
Phloretin either alone or in combination with duloxetine alleviates the STZ-induced diabetic neuropathy in rats
Keywords: Phloretin; Duloxetine; STZ; Diabetic neuropathy; Oxidative stress; Inflammatory cytokine;
Protective effect of wax apple (Syzygium samarangense (Blume) Merr. & L.M. Perry) against streptozotocin-induced pancreatic Ã-cell damage in diabetic rats
Keywords: Bcl-2; B-cell lymphoma 2; BSA; bovine serum albumin; b.w.; body weight; CAT; catalase; DAB; 3,3â²-diaminobenzidine; DM; diabetes mellitus; ELISA; enzyme-linked immunosorbent assay; FBG; fasting blood glucose; GSH-Px; gutathione peroxidase; H&E; hematoxyl
Repurposing of sodium valproate in colon cancer associated with diabetes mellitus: Role of HDAC inhibition
Keywords: ACF; aberrant crypt foci; ALP; alkaline phosphatase; ANOVA; one-way analysis of variance; CEA; carcinogenic embryonic antigen; DMH; 1,2 dimethylhydrazine; EDTA; ethylene diamine tetra acetic acid; ELISA; enzyme-linked immunosorbent assay; HbA1c; glycosyla
TRPC proteins contribute to development of diabetic retinopathy and regulate glyoxalase 1 activity and methylglyoxal accumulation
Keywords: Diabetic retinopathy; Reactive metabolites; TRPC cation channels; MethylGlyoxal; Vasoregression; Glyoxalase1; DR; Diabetic Retinopathy; GLO1; Glyoxalase 1; GSH; Glutathione; GSSG; Glutathione disulfide; HTA; Hemithioacetal; MEF; Mouse Embryonic Fibroblast
Lycium barbarum polysaccharide protects diabetic peripheral neuropathy by enhancing autophagy via mTOR/p70S6K inhibition in Streptozotocin-induced diabetic rats
Keywords: LBP; Lycium barbarum polysaccharide; DM; diabetes mellitus; DPN; diabetic peripheral neuropathy; LC3-II; microtubule-associated protein 1 light chain 3-II; HDL; high density lipoprotein; SC; Schwarm cell; STZ; streptozotocin; LA; lipoic acid; PWT; paw wit
Conformal coating by multilayer nano-encapsulation for the protection of human pancreatic islets: In-vitro and in-vivo studies
Keywords: Human islets; Islets transplantation; Multilayer nanoencapsulation; Immune isolation; Diabetes; T1D; Type 1 diabetes; MLBL; Multi-layer-by-layer; STZ; Streptozotocin; NA; Nicotinamide; IPGTT; Intraperitoneal glucose tolerance test; MPO; Myeloperoxidase; P
Antidiabetic and antihyperlipidemic effects of the flower extract of Eriobotrya japonica in streptozotocin-induced diabetic mice and the potential bioactive constituents in vitro
Keywords: Eriobotrya japonica; Diabetes; Streptozotocin; Glucose transporter 4; Akt phosphorylation; AMPK; AMP-activated protein kinase; BAT; brown adipose tissue; CON; control; EWAT; epididymal white adipose tissue; Feno; fenofibrate; FFA; free fatty acid; GAPDH;
Pinprick hypo- and hyperalgesia in diabetic rats: Can diet content affect experimental outcome?
Keywords: PDPN; painful diabetic polyneuropathy; PST; pinprick sensitivity threshold; STZ; streptozotocin; Streptozotocin-induced diabetes; Diabetic neuropathy; Evoked pricking pain; Hyperalgesia; Hypoalgesia;
A critical review on phytochemical profile and health promoting effects of mung bean (Vigna radiata)
Keywords: ABTS; 2, 2â²-azinobis 3-ethyl-benzothiazoline-6-sulphonic acid; ACC; acetyl-CoA carboxylase; ALP; alkaline phosphatase; ALT; alanine transaminases; AST; aspartate transaminase; BUN; blood urea nitrogen; C/EBPα; CCAAT/enhancer binding protein alpha; CAT;
Protective effect of the ethanol extract from Ligusticum chuanxiong rhizome against streptozotocin-induced diabetic nephropathy in mice
Keywords: AEL; aqueous extract of L. chuanxiong rhizome; ARE; antioxidant response element; COX-2; cyclooxygenase-2; DI; didox; DN; diabetic nephropathy; EEL; ethanol extract of L. chuanxiong rhizome; ELISA; enzyme linked immunosorbent assay; ESRD; end stage renal
Histamine H4 receptor antagonism prevents the progression of diabetic nephropathy in male DBA2/J mice
Keywords: ACR; albumin-creatinine-ratio; AQP; aquaporin; CrCl; creatinine clearance; ESRD; end stage renal disease; GBM; glomerular basement membrane; HDC; histidine decarboxylase; H&E; haematoxylin and eosin; HPLC; high performance liquid chromatography; H1-4Rs; h
Transcriptomic analysis of Momordica charantia polysaccharide on streptozotocin-induced diabetic rats
Keywords: M. charantia; Momordica charantia; RNA-seq; RNA sequencing; T2DM; Type 2 diabetes mellitus; IR; insulin resistance; PPAR; peroxisome proliferator-activated receptor; FBG; fasting blood glucose; G6Pase; glucose-6-phosphatase; PEPCK; phosphoenol pyruvate ca
Lower glycemic indices and lipid profile among type 2 diabetes mellitus patients who received novel dose of Silybum marianum (L.) Gaertn. (silymarin) extract supplement: A Triple-blinded randomized controlled clinical trial
Keywords: Diabetes mellitus; Silymarin; Hyperglycemia; Serum lipids; ANCOVA; analysis of covariance; BMI; body mass index; CAM; complementary and alternative medicine; FBS; fasting blood sugar; GSHPx; glutathione peroxidase; HbA1c; hemoglobin A1c; HDL-c; high-densi
High glucose up-regulates Semaphorin 3A expression via the mTOR signaling pathway in keratinocytes: A potential mechanism and therapeutic target for diabetic small fiber neuropathy
Keywords: Semaphorin 3A; Diabetic small fiber neuropathy; Keratinocyte; mTOR; 4E-BP1; Eukaryotic initiation factor 4E-binding protein 1; AD; atopic dermatitis; CPT; cold perception threshold; DPN; diabetic peripheral neuropathy; DRG; dorsal nerve root ganglia; FPG;
Inhibitory effect of Ligustrum vulgare leaf extract on the development of neuropathic pain in a streptozotocin-induced rat model of diabetes
Keywords: Ligustrum vulgare; Diabetic neuropathy; Hyperalgesia; Allodynia; Oleacein; 5-LOX; 5 - lipoxygenase; ACE; angiotensin converting enzyme; CCI; chronic constriction injury; COX-2; cyclooxygenase - 2; DPN; painful diabetic neuropathy; ICAM-1; intercellular ad
Therapeutic potentials of Houttuynia cordata Thunb. against inflammation and oxidative stress: A review
Keywords: NCBI; National Centre for Biotechnology Information; SARS; Severe acute respiratory syndrome; NO; Nitric Oxide; LPS; Lipopolysaccharide; NF-κB; Nuclear factor kappa B; ROS; Reactive Oxygen Species; TNF-α; Tumor Necrosis Factor-α; IL; Interleukin; MCP-1
Validation of the antihyperglycaemic and hepatoprotective activity of the flavonoid rich fraction of Brachychiton rupestris using in vivo experimental models and molecular modelling
Keywords: Antihyperglycemic activity; Brachychiton rupestris; Hepatoprotective activity; LC-ESI-MS profiling; Malvaceae; Molecular modelling; ALT; Alanine aminotransferase; AST; Aspartate aminotransferase; ATP; Adenosine triphosphate; B; Brachychiton; BRE; Ethyl ac
Fasting exacerbates hepatic growth differentiation factor 15 to promote fatty acid β-oxidation and ketogenesis via activating XBP1 signaling in liver
Keywords: GDF15; growth differentiation factor 15; UPR; unfolded protein response; IRE1α; inositol requiring enzyme 1 alpha; XBP1; x-box binding protein 1; STZ; streptozotocin; ChIP; chromatin immunoprecipitation; ERSE; ER stress-response element; Ppara; peroxisom