کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
11025561 | 1678522 | 2019 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Post-stroke neovascularization and functional outcomes differ in diabetes depending on severity of injury and sex: Potential link to hemorrhagic transformation
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کلمات کلیدی
Goto-KakizakiFITCNORFFATTCHFDMCAOSTZ2,3,5-triphenyltetrazolium chloride - 2،3،5-trihenyltetrazolium chlorideNeurovascular injury - آسیب عصبی عضلانیstreptozotocin - استرپتوزوتوسینFree fatty acids - اسیدهای چرب آِزادmiddle cerebral artery occlusion - انسداد شریان (سرخرگ) مغزی میانیDiabetes - بیماری قندhemorrhagic transformation - تحول هموراژیکHigh fat diet - رژیم غذایی با چربی بالاFemale - زنIschemic stroke - سکته مغزی ایسکمیکNovel object recognition - شناسایی شیء رمانfluorescein isothiocyanate - فلوئورسین ایسوتیوسیاناتHemoglobin - هموگلوبینART - هنر
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
عصب شناسی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Diabetes is associated with increased risk and worsened outcome of stroke. Previous studies showed that male diabetic animals had greater hemorrhagic transformation (HT), profound loss of cerebral vasculature, and poor behavioral outcomes after ischemic stroke induced by suture or embolic middle cerebral artery occlusion (MCAO). Females are protected from stroke until reaching the menopause age, but young females with diabetes have a higher risk of stroke and women account for the majority of stroke mortality. The current study postulated that diabetes is associated with greater vascular injury and exacerbated sensorimotor and cognitive outcome after stroke even in young female animals. Male and female control and diabetic animals were subjected to transient MCAO and followed for 3 or 14â¯days to assess the neurovascular injury and repair. The vascularization indices after stroke were lower in male diabetic animals with 90-min but not 60-min ischemia/reperfusion injury, while there was no change in female groups. Cognitive deficits were exacerbated in both male and female groups regardless of the injury period, while the sensorimotor dysfunction was worsened in male diabetic animals with longer ischemia time. These results suggest that diabetes negates the protection afforded by sex in young female animals, and post-stroke vascularization pattern is influenced by the degree of injury and correlates with functional outcome in both sexes. Vasculoprotection after acute ischemic stroke may provide a novel therapeutic strategy in diabetes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Neurology - Volume 311, January 2019, Pages 106-114
Journal: Experimental Neurology - Volume 311, January 2019, Pages 106-114
نویسندگان
Weiguo Li, John Paul Valenzuela, Rebecca Ward, Mahmoud Abdelbary, Guangkuo Dong, Susan C. Fagan, Adviye Ergul,