DJ-1 protects the heart against ischemia-reperfusion injury by regulating mitochondrial fission
Keywords: DJ-1; Myocardial ischemia; Mitochondrial fission; SUMOylation;
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PIAS1 binds p300 and behaves as a coactivator or corepressor of the transcription factor c-Myb dependent on SUMO-status
Keywords: Transcription factor; c-Myb; PIAS1; p300; SUMOylation; Coactivator2KR, double mutant of c-Myb (K503R + K527R); 6KR, multiple mutant of c-Myb with the following alterations (K428/442/445/471/480/485R); AR, androgen receptor; BRD4, member of the BET (bromod
Transcription regulation of nuclear receptor PXR: Role of SUMO-1 modification and NDSM in receptor function
Keywords: Nuclear receptor; SUMOylation; PXR; Transcription factor; Xenobiotic metabolism;
SUMOylation of Rad52-Rad59 synergistically change the outcome of mitotic recombination
Keywords: Homologous recombination; Rad52; Rad59; Srs2; Rad51; SUMOylation
Activating transcription factor 3 SUMOylation is involved in angiotensin II-induced endothelial cell inflammation and dysfunction
Keywords: Activating transcription factor 3; SUMOylation; Endothelial cell;
Becoming a crossover-competent DSB
Keywords: Meiosis; Double-strand break; Crossover; Sumoylation; Ubiquitination;
Role of RSUME in inflammation and cancer
Keywords: RWD-domain-containing sumoylation enhancer; RWDD3; Hypoxia; VHL; Sumoylation;
Characterization of amino acid residues within the N-terminal region of Ubc9 that play a role in Ubc9 nuclear localization
Keywords: Ubc9; SUMOylation; Importin 13; Nuclear import; Nuclear retention; Nuclear localization;
Precise protein post-translational modifications modulate ABI5 activity
Keywords: ABI5; ABA signaling; ubiquitination; sumoylation; (de-)phosphorylation
Analysis of PTEN ubiquitylation and SUMOylation using molecular traps
Keywords: TUBEs; Tandem Ubiquitin Binding Entities; SUBEs; SUMO Binding Entities; PTMs; post-translational modifications; PTEN; Ubiquitylation; SUMOylation; Proteasome; Proteolysis; Degradation;
HSP27 phosphorylation protects against endothelial barrier dysfunction under burn serum challenge
Keywords: Burn; F-actin rearrangement; HSP27; Dephosphorylation; Sumoylation; Endothelial permeability;
Expression and in vitro functional analyses of recombinant Gam1 protein
Keywords: Gam1; SUMOylation; Protein expression; Trigger factor; Cold temperature
Arabidopsis CMT3 activity is positively regulated by AtSIZ1-mediated sumoylation
Keywords: AtSIZ1; SUMO; Sumoylation; CMT3; DNA methylation; DNA methyltransferase;
Advances in the development of SUMO specific protease (SENP) inhibitors
Keywords: Sumoylation; SUMO; SENP; Prostate cancer; Virtual screening
Error-free DNA-damage tolerance in Saccharomyces cerevisiae
Keywords: DNA-damage tolerance; Error-free bypass; PCNA; Ubiquitination; Sumoylation; Saccharomyces cerevisiae;
SUMOylation occurs in acute kidney injury and plays a cytoprotective role
Keywords: SUMOylation; Cisplatin nephrotoxicity; Renal ischemia–reperfusion; Apoptosis; ROS; p53
Characterization of nuclear PTEN and its post translational modifications
Keywords: PTEN; SUMOylation; ATM; DNA damage; Phosphorylation;
Activated PKR inhibits pancreatic β-cell proliferation through sumoylation-dependent stabilization of P53
Keywords: Pancreatic β-cell; Proliferation; PKR; P53; Sumoylation; Ceramide;
RSRC1 SUMOylation enhances SUMOylation and inhibits transcriptional activity of estrogen receptor β
Keywords: SUMOylation; Transcriptional activity; ERβ; RSRC1/SRrp53; PIAS1;
Oncogenic Human Papillomavirus 16E7 modulates SUMOylation of FoxM1b
Keywords: HPV; human papillomavirus; FoxM1b; Forkhead box transcription factor M1b; HEK293T; human embryonic kidney 293T cells; SUMO; small ubiquitin-like modifier; CHX; cycloheximide; PIAS1; protein inhibitor of activated STAT (signal transducer and activator of t
Similarities and differences between Arabidopsis PCNA1 and PCNA2 in complementing the yeast DNA damage tolerance defect
Keywords: Arabidopsis; PCNA; Ubiquitination; Sumoylation; DNA damage tolerance; Protein–protein interaction
Uncoupling phototoxicity-elicited neural dysmorphology and death by insidious function and selective impairment of Ran-binding protein 2 (Ranbp2)
Keywords: CLD; cyclophilin-like domain; CLDm; cyclophilin-like domain mutant; SBM; SUMO-binding motif; Ranbp2; Ran-binding protein 2; Tg; transgenic; UPS; ubiquitin-proteasome system; ubc9; ubiquitin carrier protein 9; SUMO; small ubiquitin-like modifier; RanGAP;
SUMOylation of insulin-like growth factor 1 receptor, promotes proliferation in acute myeloid leukemia
Keywords: Acute myeloid leukemia; Insulin-like growth factor receptor; SUMOylation; Targeted therapy;
Mec1-dependent phosphorylation of Mms21 modulates its SUMO ligase activity
Keywords: Mms21; SUMOylation; Smc5/6; Phosphorylation; Mec1
miR-200c-SUMOylated KLF4 feedback loop acts as a switch in transcriptional programs that control VSMC proliferation
Keywords: ATRA; all-trans retinoic acid; cdk2; cyclin-dependent kinase 2; HASMC; human aortic smooth muscle cell; HDAC2; histone deacetylase 2; KLF; Krüppel-like factor; LSD1; lysine-specific demethylase 1; miR; microRNA; NCoR; nuclear receptor corepressor; p21; p
MxA interacts with and is modified by the SUMOylation machinery
Keywords: MX1; MxA; Yeast two-hybrid; SUMOylation; EIL loop; SUMO; Ubc9 and antiviral activity;
Proteome-wide analysis of SUMO2 targets in response to pathological DNA replication stress in human cells
Keywords: DTT; dithiothreitol; EGTA; ethylene glycol tetraacetic acid; FACS; fluorescence-activated cell sorting; HA; human influenza hemagglutinin; HCD; higher-energy collisional dissociation; HPLC; high performance liquid chromatography; PCNA; proliferating cellu
SUMOylation of Argonaute-2 regulates RNA interference activity
Keywords: SUMOylation; Argonaute; PIAS3; Ubc9; RNAi;
Sumoylation controls CLOCK-BMAL1-mediated clock resetting via CBP recruitment in nuclear transcriptional foci
Keywords: Circadian clock; BMAL1; CBP; Sumoylation; Nuclear body; BiFC-based FRET; SUSP1; Clock resetting;
Cigarette smoke affects posttranslational modifications and inhibits capacitation-induced changes in human sperm proteins
Keywords: HTF, human tubal fluid; CSE, cigarette smoke extract; HSA, human serum albuminSperm; Tobacco; Capacitation; Sumoylation; Phophorylation
Analysis of PTP1B sumoylation
Keywords: Signal transduction; Protein tyrosine phosphatases; Phosphorylation; Posttranslational modification; Sumoylation;
α-Lipoic acid (α-LA) inhibits the transcriptional activity of interferon regulatory factor 1 (IRF-1) via SUMOylation
Keywords: Osteoarthritis; Interleukin (IL)-1β; Lipoic acid; Interferon regulatory factor 1; Chondrocyte; SUMOylation;
Post-translational modifications of the mineralocorticoid receptor: How to dress the receptor according to the circumstances?
Keywords: Aldosterone; Glucocorticoids; Steroid receptors; Protein modifications; Phosphorylation; Ubiquitylation; Sumoylation; Acetylation; Oxidation;
Sumoylation modulates 20-hydroxyecdysone signaling by maintaining USP protein levels in Drosophila
Keywords: Sumoylation; USP; 20-Hydroxyecdysone; Transcriptional activity; Protein level;
Interplay between nuclear transport and ubiquitin/SUMO modifications in the regulation of cancer-related proteins
Keywords: Nucleocytoplasmic transport; NLS; NES; CRM1; Ubiquitylation; Sumoylation
SUMO-specific protease 1 modulates cadmium-augmented transcriptional activity of androgen receptor (AR) by reversing AR SUMOylation
Keywords: Cadmium; SENP1; Androgen receptor; Transcriptional activity; SUMOylation; Prostate cancer;
The conserved sumoylation consensus site in TRIM5α modulates its immune activation functions
Keywords: CA; capsid; HEK; human embryonic kidney; HTLV; human T-cell leukemia virus; IF; immunofluorescence; IP; immunoprecipitation; LMB; leptomycin B; MOI; multiplicity of infection; NB; nuclear body; PBS; phosphate buffer saline; PML; promyelocytic leukemia; SU
A conserved SUMOylation signaling for cell cycle control in a holocentric species Bombyx mori
Keywords: SUMOylation; Expression; Localization; Cell cycle; Silkworm;
Sumoylation regulates ER stress response by modulating calreticulin gene expression in XBP-1-dependent mode in Caenorhabditis elegans
Keywords: Sumoylation; XBP-1; UBC-9; Calreticulin; ER stress;
Thy1.2 driven expression of transgenic His6-SUMO2 in the brain of mice alters a restricted set of genes
Keywords: SUMOylation; Transgenic mice; Affinity tag; Penk1; Gene array;
Regulation of cardiac proteasomes by ubiquitination, SUMOylation, and beyond
Keywords: Ubiquitin-proteasome system; Acetylation; Methylation; Ubiquitination; SUMOylation; Cardiovascular disease;
SUMOylation of RhoGDIα is required for its repression of cyclin D1 expression and anchorage-independent growth of cancer cells
Keywords: RhoGDIα; SUMOylation; Cyclin D1; Growth arrest; Anchorage-independent growth; CDK; cyclin-dependent kinase; Erk; extracellular stimuli mitogen-activated protein kinase; GDIs; GDP-dissociation inhibitors; GEFs; guanine nucleotide exchanging factors; GTP;
SUMOylation and deimination of proteins: Two epigenetic modifications involved in Giardia encystation
Keywords: Arginine deiminase; SUMOylation; Nuclear localization; Encystation; Parasites;
Histone deacetylase 2 controls p53 and is a critical factor in tumorigenesis
Keywords: Cancer; HDAC inhibitors; HDAC2; p53; RLIM; Sumoylation;
Identification of quinazolinyloxy biaryl urea as a new class of SUMO activating enzyme 1 inhibitors
Keywords: Sumoylation; SUMO E1; Virtual screening; Molecular docking; Quinazolinyloxy biaryl urea;
SUMOylation negatively regulates the stability of CHFR tumor suppressor
Keywords: CHFR; Tumor suppressor; Ubiquitination; SUMOylation; SENP2; Protein stability;
SUMOylation of damaged DNA-binding protein DDB2
Keywords: DDB2; SUMOylation; PIASy; NER; UV damage;
Beside the MEF2 axis: Unconventional functions of HDAC4
Keywords: Histone deacetylase; MEF2; HIF; STAT1; FOXOs; Foxp3; Sumoylation; Metabolism; Muscle; LXB;
HDAC3 interacts with sumoylated C/EBPα to negatively regulate the LXRα expression in rat hepatocytes
Keywords: CBS; C/EBPα binding site; C/EBPs; CCAAT/enhancer binding proteins; ChIP; chromatin immunoprecipitation assay; Co-IP; co-immunoprecipitation; CYP7A1; cholesterol 7α-hydroxylase; FAS; fatty acid synthase; HDAC; histone deacetylase; HFD-MetS; high-fat-diet
Multidomain sumoylation of the ecdysone receptor (EcR) from Drosophila melanogaster
Keywords: 20E; 20-hydroxyecdysone; DBD; DNA-binding domain; EcR; ecdysone receptor; HEK293; human embryonic kidney 293 cells; ID; intrinsically disordered; LBD; ligand-binding domain; MS; mass spectrometry; NR; nuclear receptor; RXR; retinoid X receptor; SUMO; smal