Keywords: مرگ و میر مصنوعی; Triple negative breast cancer; Homologous recombination; Synthetic lethality; PARP; PARP inhibitors;
مقالات ISI مرگ و میر مصنوعی (ترجمه نشده)
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در صورتی که به ترجمه آماده هر یک از مقالات زیر نیاز داشته باشید، می توانید سفارش دهید تا مترجمان با تجربه این مجموعه در اسرع وقت آن را برای شما ترجمه نمایند.
Keywords: مرگ و میر مصنوعی; Protein phosphatase; Tumor suppressor; Phosphatase reactivation therapy; Synthetic lethality; Predictive marker; Prognostic marker; PP2A; PPM; ILKAP; PDP; PHLPP; PTPR; PTPN; DUSP; ACPP;
Keywords: مرگ و میر مصنوعی; Mismatch Repair; Therapies; Synthetic lethality;
Keywords: مرگ و میر مصنوعی; DNA repair; homologous recombination; alternative end joining; Polθ; synthetic lethality
Keywords: مرگ و میر مصنوعی; Synthetic lethality; Epigenetics; High-throughput screening; Genomics; Signaling networksATM, ataxia telangiectasia, mutated; ATR, ATM and Rad3-related; ATRIP, ATR-interacting protein; BAF, Brg1-associated factor; BER, base excision repair; BRCA1, breast
Keywords: مرگ و میر مصنوعی; Signaling network; High-throughput data; Cancer; Drug response; Synthetic lethality; Targeted treatment;
Keywords: مرگ و میر مصنوعی; Head and neck cancer; Squamous cell carcinoma; Molecular biology; Targeted therapy; Synthetic lethality; Genomic sequencing; Intratumor heterogeneity;
Keywords: مرگ و میر مصنوعی; Ovarian cancer; HNPCC; Mismatch repair deficiency; Synthetic lethality;
Keywords: مرگ و میر مصنوعی; chromatin-modifying enzymes; drugs; therapeutics; synthetic lethality; non-oncogene addiction
Keywords: مرگ و میر مصنوعی; negative genetic interaction; synthetic lethality; synthetic dosage lethality; pooled shRNA and sgRNA screening; high resolution phenotypic interactions
Melanoma metabolism contributes to the cellular responses to MAPK/ERK pathway inhibitors
Keywords: مرگ و میر مصنوعی; MAPK; mitogen-activated protein kinase; BRAF; v-raf murine sarcoma viral oncogene homolog B1; MEK; mitogen-activated protein/extracellular signal- regulated kinase kinase; ERK; extracellular signal-regulated kinase; HIF-1α; hypoxia inducible factor 1 alp
Re-engineering and evaluation of anti-DNA autoantibody 3E10 for therapeutic applications
Keywords: مرگ و میر مصنوعی; 3E10; Di-scFv; Autoantibody; DNA damage repair; Synthetic lethality;
PTEN deficiency confers colorectal cancer cell resistance to dual inhibitors of FLT3 and aurora kinase A
Keywords: مرگ و میر مصنوعی; AKT; KW2449; Synthetic lethality; AURKA; Drug combination;
Metronomic oral doxorubicin in combination of Chk1 inhibitor MK-8776 for p53-deficient breast cancer treatment
Keywords: مرگ و میر مصنوعی; Oral chemotherapy; Metronomic chemotherapy; Chk1 inhibitor; p53-deficient breast cancer; Doxorubicin; Synthetic lethality; MK-8776; Breast cancer;
ATM inhibition induces synthetic lethality and enhances sensitivity of PTEN-deficient breast cancer cells to cisplatin
Keywords: مرگ و میر مصنوعی; ATM inhibition; PTEN; Synthetic lethality; Cisplatin; Breast cancer;
ARID1A mutant ovarian clear cell carcinoma: A clear target for synthetic lethal strategies
Keywords: مرگ و میر مصنوعی; Synthetic lethality; ARID1A; SWI/SNF; Ovarian clear cell carcinoma;
Interrogation of ethnomedicinal plants for synthetic lethality effects in combination with deficiency in the DNA repair endonuclease RAD1 using a yeast cell-based assay
Keywords: مرگ و میر مصنوعی; NER; Nucleotide excision repair; BER; base excision repair; AO; acridine orange; Ethnomedicinal plants; Colorectal cancer; Synthetic lethality; Chemical genetics; Yeast;
Identifying synthetic lethal targets using CRISPR/Cas9 system
Keywords: مرگ و میر مصنوعی; Synthetic lethality; CRISPR/Cas9; Knockout library; Arrayed screen; Pooled screen;
Design, synthesis and biological activity of novel molecules designed to target PARP and DNA
Keywords: مرگ و میر مصنوعی; PARP inhibitors; BRCA mutation; Synthetic lethality; DNA damage; Bis-targeting;
Targeting DNA repair for precision radiotherapy: Balancing the therapeutic ratio
Keywords: مرگ و میر مصنوعی; DNA repair; Radiosensitizing; Synthetic lethality; Precision radiotherapy; Prognostic biomarker; Predictive biomarker; Genomics; Prostate cancer;
Specific killing of DNA damage-response deficient cells with inhibitors of poly(ADP-ribose) glycohydrolase
Keywords: مرگ و میر مصنوعی; Synthetic lethality; Breast cancer; PARG inhibition; FAM175A (ABRAXAS); BRCA1; PALB2; BARD1;
Poly(ADP-ribose) polymerase activity and inhibition in cancer
Keywords: مرگ و میر مصنوعی; Poly(ADP-ribose) polymerase; Synthetic lethality; PARP; DNA repair; PARP inhibitors;
Cancer-Specific Synthetic Lethality between ATR and CHK1 Kinase Activities
Keywords: مرگ و میر مصنوعی; ATR; CHK1; synthetic lethality; cancer; DNA damage; replication stress
ReviewNetwork pharmacology of cancer: From understanding of complex interactomes to the design of multi-target specific therapeutics from nature
Keywords: مرگ و میر مصنوعی; Eleutherococcus senticosus; Genomics; Green tea polyphenolics; Lithospermum erythrorhizon; Metabolomics; Polypharmacology; Proteomics; Rhodiola rosea; Schisandra chinensis; Synthetic lethality; Systems biology; Transcriptomics;
Mutant KRAS as a critical determinant of the therapeutic response of colorectal cancer
Keywords: مرگ و میر مصنوعی; Colorectal cancer; EGFR; KRAS; Synthetic lethality; Targeted therapy
Hitting cancers’ weak spots: vulnerabilities imposed by p53 mutation
Keywords: مرگ و میر مصنوعی; p53; synthetic lethality; cancer therapy
De la découverte du poly(ADP-ribose) aux inhibiteurs PARP en thérapie du cancer
Keywords: مرگ و میر مصنوعی; Poly(ADP-ribose) polymérase; Inhibiteurs PARP; Réparation de l'ADN; Chimio- et radiothérapie; BRCA1/2; Létalité synthétique; Poly(ADP-ribose) polymerase; PARP inhibitors; DNA repair; Chemo- and radiotherapy; BRCA1/2; Synthetic lethality;
Targeting homologous recombination, new pre-clinical and clinical therapeutic combinations inhibiting RAD51
Keywords: مرگ و میر مصنوعی; RAD51; Homologous recombination; Targeted therapy; Combination therapy; DNA damage response; Synthetic lethality
Targeting BRCA1-BER deficient breast cancer by ATM or DNA-PKcs blockade either alone or in combination with cisplatin for personalized therapy
Keywords: مرگ و میر مصنوعی; BRCA1; Base excision repair; ATM; DNA-PK; Small molecule inhibitors; Synthetic lethality; Cisplatin; Chemopotentiation;
Exploiting DNA mismatch repair deficiency as a therapeutic strategy
Keywords: مرگ و میر مصنوعی; Mismatch repair; Synthetic lethality; Drug resistance; Therapeutics;
Poly(ADP-ribose)polymerase (PARP) Inhibitors: From Bench to Bedside
Keywords: مرگ و میر مصنوعی; Chemo-potentiation; DNA damage response; poly(ADP-ribose)polymerase (PARP); radio-potentiation; synthetic lethality;
Genomic insights into WNT/β-catenin signaling
Keywords: مرگ و میر مصنوعی; WNT; cancer; β-catenin; YAP1; synthetic lethality
Triple negative breast cancer therapy with CDK1 siRNA delivered by cationic lipid assisted PEG-PLA nanoparticles
Keywords: مرگ و میر مصنوعی; Triple-negative breast cancer; Synthetic lethality; siRNA delivery; Cationic lipid assisted nanoparticle; Cyclin-dependent kinase 1
Inhibiteurs de PARP et radiothérapie : rationnel et perspectives pour une utilisation en clinique
Keywords: مرگ و میر مصنوعی; Inhibiteur de PARP; Létalité synthétique; Mutations BRCA1/2; Chimiothérapie; RadiothérapiePARP inhibitor; Synthetic lethality; BRCA1/2 mutations; Chemotherapy; Radiotherapy
Inhibition of poly(ADP-ribosyl)ation in cancer: Old and new paradigms revisited
Keywords: مرگ و میر مصنوعی; Poly(ADP-ribose) polymerase; BRCAness; Tankyrase; DNA repair; Synthetic lethality; Targeted cancer therapies;
Prodrug oncrasin-266 improves the stability, pharmacokinetics, and safety of NSC-743380
Keywords: مرگ و میر مصنوعی; Cancer; Drug development; Prodrug; Synthetic lethality;
Proposal for a new therapy for drug-resistant malaria using Plasmodium synthetic lethality inference
Keywords: مرگ و میر مصنوعی; SL, synthetic lethal; P., Plasmodium; ADR, antimalarial drug resistance; SW, Smith–Waterman; GO, gene ontology; GOA, gene ontology annotation; PDB, Protein Data BankDrug-resistant malaria; Synthetic lethality; Drug targeting; Antimalarial therapy
Poly(Adenosine Diphosphate-Ribose) Polymerase Inhibitors in Cancer Treatment
Keywords: مرگ و میر مصنوعی; Poly(ADP-ribose) polymerase; Inhibitor; Synthetic lethality; BRCA;
Synthetic lethality: General principles, utility and detection using genetic screens in human cells
Keywords: مرگ و میر مصنوعی; Synthetic lethality; Genetic screens; Cancer;
The underlying mechanism for the PARP and BRCA synthetic lethality: Clearing up the misunderstandings
Keywords: مرگ و میر مصنوعی; Review; Homologous recombination; Stalled replication fork; DNA double-strand breaks; Poly(ADP-ribose) polymerase; BRCA1; BRCA2; Synthetic lethality; Cancer
Targeting DNA repair pathways in AML
Keywords: مرگ و میر مصنوعی; acute myeloid leukemia; AML; DNA repair pathway; Fanconi anemia; FA; poly-ADP-ribose polymerase (PARP) inhibitors; synthetic lethality
PARP inhibitors in cancer therapy: Two modes of attack on the cancer cell widening the clinical applications
Keywords: مرگ و میر مصنوعی; DNA repair; PARP inhibitors; Olaparib; Synthetic lethality; Chemopotentiation
Genetic interaction and phenotypic analysis of the Arabidopsis MAP kinase pathway mutations mekk1 and mpk4 suggests signaling pathway complexity
Keywords: مرگ و میر مصنوعی; MAP kinase; Synthetic lethality; MEKK1; MPK4; Arabidopsis
dSLAM analysis of genome-wide genetic interactions in Saccharomyces cerevisiae
Keywords: مرگ و میر مصنوعی; Synthetic lethality; Microarrays; Molecular barcodes; Genetic interaction; Genome-wide analysis; Compound-gene interactions;
Studying phospholipid metabolism using yeast systematic and chemical genetics
Keywords: مرگ و میر مصنوعی; Synthetic lethality; Chemical genetics; Saccharomyces cerevisiae; Yeast; Robotics; Phospholipid; Lipid; Metabolism;
Lethality and synthetic lethality in the genome-wide metabolic network of Escherichia coli
Keywords: مرگ و میر مصنوعی; Metabolic network; Flux balance analysis; Synthetic lethality; FBA: flux balance analysis; CLS: cumulative lethality score;