کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5698624 1410374 2014 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Poly(ADP-ribose)polymerase (PARP) Inhibitors: From Bench to Bedside
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی تومور شناسی
پیش نمایش صفحه اول مقاله
Poly(ADP-ribose)polymerase (PARP) Inhibitors: From Bench to Bedside
چکیده انگلیسی
Poly(ADP-ribose)polymerase (PARP) inhibitors are a novel class of anticancer agents that target the DNA damage response pathways. The enzyme target, PARP, plays a key role in signalling DNA single-strand breaks. Clinical development to date has focused on their potential role in combination with DNA-damaging chemotherapy, where efficacy has been limited by enhanced normal tissue toxicity, and as single agents in the context of synthetic lethality. This article reviews these data in the context of future development as radio-potentiating agents.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Oncology - Volume 26, Issue 5, May 2014, Pages 250-256
نویسندگان
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