Paclitaxel suppresses Tau-mediated microtubule bundling in a concentration-dependent manner
Keywords: خود را; Tau; Paclitaxel; Microtubule; Small-angle X-ray scattering;
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O-GlcNAcylation and neurodegeneration
Keywords: خود را; OGT; OGA; Tau; Synuclein; Amyloid; Huntingtin; Aging; Autophagy;
Structure guided design of a series of selective pyrrolopyrimidinone MARK inhibitors
Keywords: خود را; MARK; Kinase; Tau; Alzheimer's disease; Pyrrolopyrimidinone;
A multinational study distinguishing Alzheimer's and healthy patients using cerebrospinal fluid tau/Aβ42 cutoff with concordance to amyloid positron emission tomography imaging
Keywords: خود را; Alzheimer's disease; Diagnostic test assessment; PET; Amyloid β42; Tau;
Featured ArticlePrevention of tau increase in cerebrospinal fluid of APP transgenic mice suggests downstream effect of BACE1 inhibition
Keywords: خود را; Alzheimer's disease; Biomarker; CSF; Tau; BACE1 inhibitor; Treatment;
TDP-43 expression influences amyloidβ plaque deposition and tau aggregation
Keywords: خود را; TDP-43; TARDBP; APP; Calcineurin; Alzheimer's disease; APP/PS1; Tau;
Mitochondrial Ca2+ handling in Huntington's and Alzheimer's diseases - Role of ER-mitochondria crosstalk
Keywords: خود را; Mitochondria; Calcium signaling; Endoplasmic reticulum; Mutant huntingtin; Amyloid-beta peptide; Tau;
Excessive tau accumulation in the parieto-occipital cortex characterizes early-onset Alzheimer's disease
Keywords: خود را; Alzheimer's disease; Mild cognitive impairment; Early onset; Tau; Positron emission tomography;
Tau and amyloid β proteins distinctively associate to functional network changes in the aging brain
Keywords: خود را; Aging; Alzheimer's disease; PET; Tau; Amyloid; Brain functional network;
N-stearoyl-l-Tyrosine inhibits the cell senescence and apoptosis induced by H2O2 in HEK293/Tau cells via the CB2 receptor
Keywords: خود را; Alzheimer's disease; Tau; Cellular senescence; Endocannabinoids; Apoptosis;
Systemic and network functions of the microtubule-associated protein tau: Implications for tau-based therapies
Keywords: خود را; Aβ; amyloid beta; AD; Alzheimer's disease; AMPAR; AMPA-type glutamate receptor; CNS; central nervous system; FTDP-17; frontotemporal dementia with parkinsonism linked to chromosome 17; GFP; green fluorescent protein; GSK-3β; glycogen synthase kinase-3β
Association between Aβ and tau accumulations and their influence on clinical features in aging and Alzheimer's disease spectrum brains: A [11C]PBB3-PET study
Keywords: خود را; Tau; Amyloid; Brain atrophy; Cognitive decline; Biomarkers; Alzheimer's disease; MCI; Preclinical; Dementia; Aging; Cognitive reserve; Positron emission tomography; [11C]PBB3; [11C]PiB;
Association between CSF biomarkers, hippocampal volume and cognitive function in patients with amnestic mild cognitive impairment (MCI)
Keywords: خود را; Mild cognitive impairment; Prodromal; Alzheimer's disease; Cognitive assessment; CANTAB; CSF; Amyloid; Tau; Hippocampal volume;
Synthesis and characterization of styryl-BODIPY derivatives for monitoring in vitro Tau aggregation
Keywords: خود را; BODIPY; Fluorescence; Tau; Wolff-Kishner reduction;
The association between tau PET and retrospective cortical thinning in clinically normal elderly
Keywords: خود را; Tau; Atrophy; Neurodegeneration; Longitudinal; Aging; Alzheimer's disease;
Inflammation in Alzheimer's disease: Lessons learned from microglia-depletion models
Keywords: خود را; Microglia; Colony-stimulating factor 1 receptor; Inflammation; Alzheimer's disease; Amyloid; Tau; Spines;
The DIAN-TU Next Generation Alzheimer's prevention trial: Adaptive design and disease progression model
Keywords: خود را; Alzheimer's disease; Alzheimer's prevention trial; Adaptive clinical trial; Biomarkers; Disease progression model; Cognitive composite; Dose adjustment; DIAN-TU; Amyloid; Tau; Autosomal dominant Alzheimer's disease;
Role of low-voltage-activated calcium current and extracellular calcium in controlling the firing pattern of developing CA1 pyramidal neurons
Keywords: خود را; ACSF; artificial cerebrospinal fluid; ADP; spike after-depolarization; AP; action potential; BAPTA; 1,2-bis (2-aminophenoxy) ethane N,N,Nâ²,Nâ²-tetraacetic acid; BS; burst-spiking; EGTA; ethylene glycol tetraacetic acid; GABA; γ-aminobutyric acid; HVA;
Regular articleAltered protein glycosylation predicts Alzheimer's disease and modulates its pathology in disease model Drosophila
Keywords: خود را; Alzheimer's disease; Tauopathy; Glycosylation; Tau; Drosophila;
Mitochondrial hyperpolarization in iPSC-derived neurons from patients of FTDP-17 with 10+16 MAPT mutation leads to oxidative stress and neurodegeneration
Keywords: خود را; 2-NBDG; 2-(N-(7-Nitrobenz-2-oxa-1,3-diazol-4-yl)Amino)-2-Deoxyglucose; AD; Alzheimer's disease; CBD; Corticobasal Degeneration; CSF; Cerebrospinal Fluid; DHE; Dihydroethidium; ETC; Electron Transport Chain; FCCP; Carbonyl cyanide-4-(trifluoromethoxy)pheny
Normalizing the gene dosage of Dyrk1A in a mouse model of Down syndrome rescues several Alzheimer's disease phenotypes
Keywords: خود را; Dyrk1A; Senescence; Neurodegeneration; APP; Tau; Ts65Dn; Down syndrome;
Research PaperAxonal dystrophy in the brain of mice with Sanfilippo syndrome
Keywords: خود را; Spheroid; Neurodegenerative disease; Endosome; Lysosomal storage disorder; Synuclein; Amyloid; Tau;
Detection of the tau protein in human serum by a sensitive four-electrode electrochemical biosensor
Keywords: خود را; Alzheimer's disease; Biomarker; Electrochemical biosensor; Impedance; Tau;
Comparison of multiple tau-PET measures as biomarkers in aging and Alzheimer's disease
Keywords: خود را; Tau; β-amyloid; Positron emission tomography; AV-1451; Biomarker; Alzheimer's disease;
mTOR and neuronal cell cycle reentry: How impaired brain insulin signaling promotes Alzheimer's disease
Keywords: خود را; Amyloid-β oligomers; Tau; Rac1; Alzheimer's disease; Cell cycle reentry; Insulin; Diabetes;
Tau protein (MAPT) as a possible biochemical marker of traumatic brain injury in postmortem examination
Keywords: خود را; Traumatic brain injury; Tau; Cerebrospinal fluid; Neuroglia pathology; Endothelial cells; Glymphatic system;
Clinical validity of cerebrospinal fluid Aβ42, tau, and phospho-tau as biomarkers for Alzheimer's disease in the context of a structured 5-phase development framework
Keywords: خود را; Cerebrospinal fluid; Beta-amyloid; Tau; Phosphorylated tau; Biomarker development; Early diagnosis; Biomarker-based diagnosis; Alzheimer's disease; 5-Phases;
Regulation of protein kinase C-related kinase (PRK) signalling by the TPα and TPβ isoforms of the human thromboxane A2 receptor: Implications for thromboxane- and androgen- dependent neoplastic and epigenetic responses in prostate cancer
Keywords: خود را; ADT; androgen deprivation therapy; AR; androgen receptor; ARE; androgen response element; AA; arachidonic acid; BCR; biochemical recurrence; ChIP; chromatin immunoprecipitation; COX; cyclooxygenase/prostaglandin G2/H2 synathase; CRPC; castrate resistant p
Self-reported traumatic brain injury and in vivo measure of AD-vulnerable cortical thickness and AD-related biomarkers in the ADNI cohort
Keywords: خود را; Traumatic brain injury; Alzheimer's disease; Cortical thickness; CSF biomarkers; Beta-amyloid; Tau;
An evaluation of the utility of LVdP/dt40, QA interval, LVdP/dtmin and Tau as indicators of drug-induced changes in contractility and lusitropy in dogs
Keywords: خود را; Myocardial; Contractility; Left ventricular dP/dt; Beagle dog; Pimobendan; Atenolol; Itraconazole; Amrinone; Heart rate; Lusitropy; Arterial blood pressure; QA interval; Cardiac Relaxation; Super-interval; Tau;
Induced pluripotent stem cells as a discovery tool for Alzheimer׳s disease
Keywords: خود را; Stem cell; iPS; Alzheimer׳s disease; Aβ; Tau; Induced pluripotent stem cell;
Simultaneous quantification of Myelin Basic Protein and Tau proteins in cerebrospinal fluid and serum of Multiple Sclerosis patients using nanoimmunosensor
Keywords: خود را; Myelin Basic Protein; Tau; Multiple Sclerosis; Immunosensor; Dendrimer; Graphene oxide; Electrochemical impedance spectroscopy; Differential pulse voltammetry;
Dexibuprofen prevents neurodegeneration and cognitive decline in APPswe/PS1dE9 through multiple signaling pathways
Keywords: خود را; AD; Alzheimer's disease; Aβ; Amyloid beta; APP; Amyloid precursor protein; NFTs; Neurofibrillary tangles; BACE1; β-secretase 1; TNF-α; Tumor necrosis factor; iNOS; Inducible nitric oxide synthase; NSAIDs; Non-steroidal anti-inflammatory drugs; PPARγ;
Targeted downregulation of dMyc restricts neurofibrillary tangles mediated pathogenesis of human neuronal tauopathies in Drosophila
Keywords: خود را; Tauopathies; Tau; Neurofibrillary tangles (NFTs); Drosophila; dMyc;
Activation of G-protein coupled estrogen receptor 1 improves early-onset cognitive impairment via PI3K/Akt pathway in rats with traumatic brain injury
Keywords: خود را; Traumatic brain injury; GPER; Apoptosis; Tau; Hippocampus;
Reconstruction of the Higgs mass in events with Higgs bosons decaying into a pair of Ï leptons using matrix element techniques
Keywords: خود را; Higgs boson; Tau; Mass reconstruction; Algorithm; Matrix element;
The protein serine/threonine phosphatases PP2A, PP1 and calcineurin: A triple threat in the regulation of the neuronal cytoskeleton
Keywords: خود را; AD; Alzheimer disease; CaM; calmodulin; CNA/B; calcineurin A/B subunit; Glu-MTs; detyrosinated microtubules; GSK3β; glycogen synthase kinase 3β; MAP; microtubule-associated protein; MARCKS; myristoylated alanine-rich C-kinase substrate; MT; microtubule;
Neocortical and hippocampal TREM2 protein levels during the progression of Alzheimer's disease
Keywords: خود را; Alzheimer's disease; Mild cognitive impairment; TREM2; Microglia; Tau; Amyloid; Immunohistochemistry; Western-blot;
The hydroxylated form of docosahexaenoic acid (DHA-H) modifies the brain lipid composition in a model of Alzheimer's disease, improving behavioral motor function and survival
Keywords: خود را; Brain lipids; PUFA; Omega-3; Amyloid; Tau; Familial Alzheimer's disease;
Electrochemical studies of tau protein-iron interactions-Potential implications for Alzheimer's Disease
Keywords: خود را; CD; circular dichroism spectroscopy; CV; cyclic voltammetry; DPV; differential pulse voltammetry; GSK3β; Glycogen synthase kinase 3-β; Lip-NHS; Lipoic acid N-hydroxysuccinimide ester; NFTs; neurofibrillary tangles; n-tau; native tau; p-tau; phosphoryl
Time course of Tau toxicity and pharmacologic prevention in a cell model of Tauopathy
Keywords: خود را; Alzheimer; Tau; Aggregation; Cell death; Inhibitor;
Neurotoxic mechanisms by which the USP14 inhibitor IU1 depletes ubiquitinated proteins and Tau in rat cerebral cortical neurons: Relevance to Alzheimer's disease
Keywords: خود را; AD; Alzheimer disease; BCA; bicinchoninic acid; Clp; calpeptin, calpain inhibitor Z-Leu-Nle-CHO; DMEM; Dulbecco's modified eagle's medium; DMSO; dimethyl sulfoxide; DTT; dithiothreitol; ECL; enhanced chemiluminescence; HAR; hexaammineruthenium; HA-Ub-VME;
In vivo tau PET imaging in dementia: Pathophysiology, radiotracer quantification, and a systematic review of clinical findings
Keywords: خود را; Dementia; Tau; PET; MRI; Neurodegeneration; Tauopathies; Cognitive impairment;
Review ArticleRecent publications from the Alzheimer's Disease Neuroimaging Initiative: Reviewing progress toward improved AD clinical trials
Keywords: خود را; Alzheimer's disease; Mild cognitive impairment; Amyloid; Tau; Biomarker; Disease progression;
Total-tau and neurofilament light in CSF reflect spinal cord ischaemia after endovascular aortic repair
Keywords: خود را; Aortic disease; Biomarker; Cerebrospinal fluid; Endovascular; NFL; Tau;
Design and synthesis of curcumin derivatives as tau and amyloid β dual aggregation inhibitors
Keywords: خود را; Alzheimer's disease; Tau; Amyloid β; Aggregation inhibitor; Curcumin;
Research articleDisinhibition-like behavior in a P301S mutant tau transgenic mouse model of frontotemporal dementia
Keywords: خود را; Frontotemporal dementia; Tau; Transgenic mouse model; Behavior;
Amyloid beta deposition and phosphorylated tau accumulation are key features in aged choroidal vessels in the complement factor H knock out model of retinal degeneration
Keywords: خود را; Retina; Aging; Macular degeneration; Tau; Amyloid beta;
miR-106b inhibits tau phosphorylation at Tyr18 by targeting Fyn in a model of Alzheimer's disease
Keywords: خود را; miR-106b; Tau; Phosphorylation; Fyn; Alzheimer's disease;
Tau phosphorylation at Alzheimer's disease-related Ser356 contributes to tau stabilization when PAR-1/MARK activity is elevated
Keywords: خود را; Tau; Phosphorylation; PAR-1/MARK; Alzheimer's disease; Neurodegeneration; Drosophila;