Keywords: Smooth muscle phenotype; Epigenetics; DNA methylation; Chromatin; Transcription; TET2
مقالات ISI (ترجمه نشده)
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Keywords: AML; acute myeloid leukemia; APL; acute promyelocytic leukemia; ASX; additional sex combs; BM; bone marrow; bZIP; leucine zipper; C/EBPα; CCAAT/enhancer binding protein α; CN-AML; normal karyotype-AML; CR; complete remissions; DFS; disease-free survival
Keywords: Systemic mastocytosis; KIT; Mutation; Signaling; TET2; ASXL1; Spliceosome; Targeted therapy;
Keywords: ÎKG; α-ketoglutarate; AML; acute myeloid leukemia; BCAT1; branched-chain amino acid transporter 1; BRD4; bromodomain-containing protein 4; D-2HG; D-2-hydroxyglutarate or R-2-hydroxyglutarate; D-2HGA; D-2-hydroxyglutarate aciduria; D2HGDH; D-2-hydroxyglu
Overexpression of Arginase 1 is linked to DNMT3A and TET2 mutations in lower-grade myelodysplastic syndromes and chronic myelomonocytic leukemia
Keywords: MDS; CMML; Arginase; Clinical risk; TET2; DNMT3A;
Double sword role of EZH2 in leukemia
Keywords: EZH1,2; enhancer of Zeste 1 and 2; SUZ12; suppressor of zeste 12 homolog; EED; embryonic ectoderm development; AEBP2; adipocyte enhancer-binding protein 2; RBAP46/48; retinoblastoma binding proteins 46 and 48; PRC; polycomb-repressive complex; PcG; Polyco
Tet2-Mediated Clonal Hematopoiesis Accelerates Heart Failure Through a Mechanism Involving the IL-1β/NLRP3 Inflammasome
Keywords: 10-11 translocation 2; clonal hematopoiesis; heart failure; interleukin-1beta; myocardial infarction; pressure overload hypertrophy; ANOVA; analysis of variance; BMT; bone marrow transplantation; CVD; cardiovascular disease; HSPC; hematopoietic stem or pr
The TET2/E-cadherin/β-catenin regulatory loop confers growth and invasion in hepatocellular carcinoma cells
Keywords: Hepatocellular carcinoma; TET2; E-cadherin; β-catenin;
The synergy of Vitamin C with decitabine activates TET2 in leukemic cells and significantly improves overall survival in elderly patients with acute myeloid leukemia
Keywords: AML; DCAG; Decitabine; Vitamin C; Elderly; TET2;
Epigenetics in myelodysplastic syndromes
Keywords: MDS; Epigenetics; ASXL1; DNMT3A; EP300; EZH2; IDH1; IDH2; KDM2B; KDM5A; KDM6A; MLL; MLL2; MLL3; MLL5; TET2; WT1; Hypomethylating agent; HDAC inhibitor;
Tet2 Regulates Osteoclast Differentiation by Interacting with Runx1 and Maintaining Genomic 5-Hydroxymethylcytosine (5hmC)
Keywords: Tet2; 5hmC; Macrophage; Osteoclast; Runx1;
Smooth muscle cell-driven vascular diseases and molecular mechanisms of VSMC plasticity
Keywords: Vascular smooth muscle; Vasoproliferative disease; Vascular smooth muscle cell; Phenotype switching; Signalling pathways; AJ; adherens junction; ApoE; apolipoprotein E; BMP; bone morphogenetic protein; CAD; coronary artery diseases; CADASIL; cerebral auto
Vitamin C down-regulate apo(a) expression via Tet2-dependent DNA demethylation in HepG2 cells
Keywords: Coronary heart diseases; Vitamin C; Apolipoprotein a; Tet2; Demethylation;
The protective role of TET2 in erythroid iron homeostasis against oxidative stress and erythropoiesis
Keywords: HAMP; hepcidin; FPN; ferroportin; ERFE; erythroferrone; TET2; Ten-Eleven Translocation 2; 5-mC; 5-methyl-cytosine; 5-hmC; 5-hydroxymethyl-cytosine; EPO; erythropoietic; MEL; mouse erythroleukemia; qRT-PCR; quantitative real-time PCR analysis; ChIP; chroma
Myocardin: A novel player in atherosclerosis
Keywords: Myocardin; Atherosclerosis; Inflammation; Lipid metabolism; VSMC; Abca1; MYOCD; Myocardin; AS; atherosclerosis; SRF; serum response factor; VSMC; vascular smooth muscle cell; Mrtf-A/B; Myocardin-related transcription factors A/B; Mamstr; Mef2-activating S
Decrease of TET2 expression and increase of 5-hmC levels in myeloid sarcomas
Keywords: (AML); acute myeloid leukemia; (ANL); acute nonlymphocytic leukemia; (5-mC); hydroxymethylcytosine; (CT); computed tomography; (5-hmC); 5-methylcytosine; (LCA); lymphocyte antigen; (HSC); hematopoietic stem cell; (LSH); lymphoid specific helicase; (MDS);
Tet oncogene family member 2 gene alterations in childhood acute myeloid leukemia
Keywords: acute myeloid leukemia; bioinformatics; children; molecular biology; TET2
Detection of TET2, KRAS and CBL variants by Next Generation Sequencing and analysis of their correlation with JAK2 and FLT3 in childhood AML
Keywords: Childhood acute myeloid leukemia; Mutation; TET2; KRAS; CBL; Next Generation Sequencing
DNMT3A R882 Mutation with FLT3-ITD Positivity Is an Extremely Poor Prognostic Factor in Patients with Normal-Karyotype Acute Myeloid Leukemia after Allogeneic Hematopoietic Cell Transplantation
Keywords: Acute myeloid leukemia; TET2; IDH1/2; DNMT3A; Allogeneic hematopoietic cell transplantation; Normal karyotype
The expression of Bcl-6 in circulating follicular helper-like T cells positively correlates with the disease activity in systemic lupus erythematosus
Keywords: Bcl-6; cTfh; SLE; Disease activity; IL-21; TET2;
TET2-mediated 5-hydroxymethylcytosine induces genetic instability and mutagenesis
Keywords: TET2; 5-hmC; TDG; Genetic instability; Cell cycle;
Active DNA demethylation by DNA repair: Facts and uncertainties
Keywords: 5mC; 5-methylcytosine; 5hmC; 5-hydroxymethylcytosine; 5hmU; 5-hydroxymethyluracil; 5fC; 5-formylcytosine; 5caC; 5-carboxycytosine; AID; activation-induced deaminase; APE1; apurinic/apyrimidinic endonuclease 1; APOBEC; apolipoprotein B mRNA editing enzyme,
TET2 expression level and 5-hydroxymethylcytosine are decreased in refractory cytopenia of childhood
Keywords: Refractory cytopenia of childhood; Myelodysplastic syndrome; Pediatrics; Epigenetics; TET2
Transformation of the Clinical Management of CMML Patients Through In-Depth Molecular Characterization
Keywords: ASXL1; Chronic myelomonocytic leukemia; Hypomethylating agent; Next-generation sequencing; TET2;
A novel del(8)(q23.2q24.11) contributing to disease progression in a case of JAK2/TET2 double mutated chronic myelomonocytic leukemia
Keywords: del(8q); CMML; TET2; JAK2; Transformation
Anomalies moléculaires au cours des mastocytoses : conséquences pronostiques et thérapeutiques
Keywords: Mastocytose systémique; Mutation; KIT; TET2; ASXL1; SRSF2; Thérapies cibléesSystemic mastocytosis; Genetic mutations; KIT; TET2; ASXL1; SRSF2; Prognosis; Therapy
CXXC4 mRNA levels are associated with clinicopathological parameters and survival of myelodysplastic syndrome patients
Keywords: Myelodysplastic syndrome; TET2; CXXC4; Prognosis;
Molecular pathogenesis of AML: Translating insights to the clinic
Keywords: acute myeloid leukemia; AML; DNA sequencing; FLT3; TET2; murine models
Reduction of DNA hydroxymethylation in the mouse kidney insulted by ischemia reperfusion
Keywords: Mouse kidney; Ischemia reperfusion; DNA hydroxymethylation; Tet2;
Using peripheral blood circulating DNAs to detect CpG global methylation status and genetic mutations in patients with myelodysplastic syndrome
Keywords: MDS; Circulating DNA; Genetic mutations; Epigenetics; LINE-1; TET2;
Free-Breathing 3 T Magnetic Resonance T2-Mapping of the Heart
Keywords: longitudinal studies; myocardial infarction; T2-mappingCI, confidence interval; CMR, cardiac magnetic resonance; FSE, fast spin echo; GRE, gradient echo; STEMI, ST-segment elevation myocardial infarction; T2prep, T2 preparation module; TE, echo time; TET2
Detection of TET2 abnormalities by fluorescence in situ hybridization in 41 patients with myelodysplastic syndrome
Keywords: MDS; conventional cytogenetics; FISH; TET2
Acquired Uniparental Disomy in Myeloproliferative Neoplasms
Keywords: Myeloproliferative neoplasm; Uniparental disomy; SNP array; TET2; CBL; EZH2; JAK2;
Role of TET2 and ASXL1 Mutations in the Pathogenesis of Myeloproliferative Neoplasms
Keywords: ASXL1; TET2; Myelofibrosis; Myeloproliferative neoplasms; JAK2;
Actualités 2011 sur la physiopathologie des syndromes myéloprolifératifs classiques hors LMC (polyglobulie de Vaquez, thrombocytémie essentielle et myélofibrose primaire)
Keywords: SMP : syndrome myéloprolifératif; PV : polyglobulie de Vaquez; TE : thrombocytémie essentielle; MPF : myélofibrose primaire; JAK2 : Janus activated kinase 2; MPL : myeloproliferative leukemia (récepteur de la thrombopoiétine); TET2 : Ten eleven tran
Clinical Implications of Novel Mutations in Epigenetic Modifiers in AML
Keywords: TET2; IDH1; IDH2; DNMT3a; Epigenetics; AML;
Spectrum of mutations in RARS-T patients includes TET2 and ASXL1 mutations
Keywords: RARS-T; TET2; ASXL1; JAK2 V617F; MPL W515L; STAT5
Significance of JAK2 and TET2 mutations in myelodysplastic syndromes
Keywords: Myelodysplasia; Ringsideroblasts; Apoptosis; JAK2; TET2
Mechanisms of mutations in myeloproliferative neoplasms
Keywords: myeloproliferative neoplasms; MPN; essential thrombocytosis; myelofibrosis; polycythaemia vera; JAK2; TET2; MPL; mutations