کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8320483 | 1539384 | 2016 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Active DNA demethylation by DNA repair: Facts and uncertainties
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
TDGGADD45A5caCPARP1DSBRAPE1PGCTET2APOBECXRCC1NEIL1poly [ADP-ribose] polymerase 1Active DNA demethylation5hmUMBD4SMUG1UNG2X-Ray Repair Cross-Complementing Protein 15fC5-carboxycytosineTET3TET1TSSMEFTETBERIPSCLMRCGIMMR5hmCDnmt5mC - 5 سانتی متر5-Hydroxymethyluracil - 5- Hydroxymethyluracil5-formylcytosine - 5-فرمیل سیتوزین5-Methylcytosine - 5-متیل سیتوزین5-hydroxymethylcytosine - 5-هیدروکسی متیل سیتوزینapurinic/apyrimidinic endonuclease 1 - apurinic / apyrimidinic endonuclease 1Thymine DNA glycosylase - DNA تلقیح گلیکوزیلازDNA methyltransferase - DNA متیل ترانسفرازNER - DOWNDNA repair - ترمیم DNADouble-strand break repair - تعمیر دوبار رشتهnucleotide excision repair - تعمیر مجدد نوکلئوتیدیmismatch repair - تعمیر ناسازگاریbase excision repair - تعمیر پایه پایهCpG island - جزیره CpGESC - خروجTranscriptional start site - سایت شروع رونویسیPrimordial germ cell - سلول های بنیادی اولیهInduced pluripotent stem cell - سلول های بنیادی پلوروپتوژن منجر شده استEmbryonic stem cells - سلولهای بنیادی جنینیActivation-induced deaminase - فعال سازی deaminase ناشی ازDNA methylation - متیلاسیون DNAmouse embryonic fibroblasts - موش فیبروبلاست جنینیAID - کمک
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Active DNA demethylation by DNA repair: Facts and uncertainties Active DNA demethylation by DNA repair: Facts and uncertainties](/preview/png/8320483.png)
چکیده انگلیسی
Pathways that control and modulate DNA methylation patterning in mammalian cells were poorly understood for a long time, although their importance in establishing and maintaining cell type-specific gene expression was well recognized. The discovery of proteins capable of converting 5-methylcytosine (5mC) to putative substrates for DNA repair introduced a novel and exciting conceptual framework for the investigation and ultimate discovery of molecular mechanisms of DNA demethylation. Against the prevailing notion that DNA methylation is a static epigenetic mark, it turned out to be dynamic and distinct mechanisms appear to have evolved to effect global and locus-specific DNA demethylation. There is compelling evidence that DNA repair, in particular base excision repair, contributes significantly to the turnover of 5mC in cells. By actively demethylating DNA, DNA repair supports the developmental establishment as well as the maintenance of DNA methylation landscapes and gene expression patterns. Yet, while the biochemical pathways are relatively well-established and reviewed, the biological context, function and regulation of DNA repair-mediated active DNA demethylation remains uncertain. In this review, we will thus summarize and critically discuss the evidence that associates active DNA demethylation by DNA repair with specific functional contexts including the DNA methylation erasure in the early embryo, the control of pluripotency and cellular differentiation, the maintenance of cell identity, and the nuclear reprogramming.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: DNA Repair - Volume 44, August 2016, Pages 92-102
Journal: DNA Repair - Volume 44, August 2016, Pages 92-102
نویسندگان
David Schuermann, Alain R. Weber, Primo Schär,