Fabrication and characterization of TGF-β1-loaded electrospun poly (lactic-co-glycolic acid) core-sheath sutures
Keywords: PLGA; Yarn; Core-sheath; Suture; TGF-β1;
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Functional importance of the TGF-β1/Smad3 signaling pathway in oxygen-glucose-deprived (OGD) microglia and rats with cerebral ischemia
Keywords: Cytokines; Microglial cells; Smad3; TGF-β1; Transfection;
FPPS mediates TGF-β1-induced non-small cell lung cancer cell invasion and the EMT process via the RhoA/Rock1 pathway
Keywords: FPPS; TGF-β1; Non-small cell lung cancer; EMT; RhoA/Rock1;
Crosstalk between transforming growth factor-β1 and endoplasmic reticulum stress regulates alpha-smooth muscle cell actin expression in podocytes
Keywords: TGF-β1; Endoplasmic reticulum stress; Epithelial-mesenchymal transition; Glomerular nephropathy; Podocytes; Smad pathway;
Protective effects of IFN-γ on the kidney of type- 2 diabetic KKAy mice
Keywords: ACR; urine albumin-to-creatinine ratio; BM; basement membrane; BS; blood sugar; BUN; blood urea nitrogen; Crea; serum creatinine; CTGF; connective tissue growth factor; DKD; diabetic kidney disease; ECM; extracellular matrix; IFN-γ; , Interferon-gamma; J
BET-inhibition by JQ1 alleviates streptozotocin-induced diabetic cardiomyopathy
Keywords: Bromodomain and extra-terminal proteins; Caveolin-1; TGF-β1; Diabetic cardiomyopathy;
Bone disease in β thalassemia patients: past, present and future perspectives
Keywords: AL; aledronate; BMD; bone mineral density; bw; body weight; BMD-L; lumbar spine bone mineral density; Ca; calcium supplementation; CLO; clodronate; COLIA1; collagen type I A1; D; vitamin D; DEXA; dual energy X-ray absorptiometry; DFO; desferrioxamine; DFP
The role of miR-328 in high glucose-induced endothelial-to-mesenchymal transition in human umbilical vein endothelial cells
Keywords: High glucose; HUVECs; miR-328; TGF-β1; EndMT; MEK1/2-ERK1/2;
Novel RAS inhibitor 25-O-methylalisol F attenuates epithelial-to-mesenchymal transition and tubulo-interstitial fibrosis by selectively inhibiting TGF-β-mediated Smad3 phosphorylation
Keywords: Renin-angiotensin system; Epithelial-to-mesenchymal transition; Kidney proximal tubular epithelial cells; Renal fibrosis; Alismatis rhizoma; 25-O-methylalisol F; ACE; renin, angiotensin-converting enzyme; ACEI; angiotensin-converting enzyme inhibitors; AG
CpG-oligodeoxynucleotides may be effective for preventing ionizing radiation induced pulmonary fibrosis
Keywords: Radiation; Pulmonary fibrosis; CpG-ODN; Macrophage; TGF-β1; Smad 2/3;
ADAM17 promotes cell migration and invasion through the integrin β1 pathway in hepatocellular carcinoma
Keywords: ADAM17; A disintegrin and metalloproteinase-17; ADAMTS; ADAMs with thrombospondin motifs; bFGF; Basic fibroblast growth factor; EGF; epidermal growth factor; ECM; extracellular matrix; GDAC; Genome Data Analysis Center; HCC; hepatocellular carcinoma; MMP;
MiR-34a/miR-93 target c-Ski to modulate the proliferaton of rat cardiac fibroblasts and extracellular matrix deposition in vivo and in vitro
Keywords: miR-34a/miR-93; C-ski; TGF-β1; Primary rat cardiac fibroblasts; Cardiac fibrosis; Extracellular matrix (ECM);
Macrophages Promote Wound-Induced Hair Follicle Regeneration in a CX3CR1- and TGF-β1-Dependent Manner
Keywords: d.p.i.; days postinjury; DT; diphtheria toxin; DTR; diphtheria toxin receptor; HF; hair follicle; HFSC; hair follicle stem cell; LAP; latency-associated peptide; PBS; phosphate-buffered saline; pSMAD; phosphorylated SMAD; TGF-β1; transforming growth fact
The glucagon-like peptide-1 (GLP-1) analog liraglutide attenuates renal fibrosis
Keywords: CKD; chronic kidney disease; ESRD; end-stage renal disease; UUO; unilateral ureteral obstruction; EMT; epithelial-mesenchymal transition; ECM; extracellular matrix; GLP-1; glucagon-like peptide-1; GLP-1R; glucagon-like peptide-1 receptor; TGF-β1; transfo
Cordyceps sinensis: Anti-fibrotic and inflammatory effects of a cultured polysaccharide extract
Keywords: Cordyceps sinensis; Bioactivity; Polysaccharide; Fibrosis; Inflammation; IL-1β; TGF-β1;
Serelaxin inhibits differentiation and fibrotic behaviors of cardiac fibroblasts by suppressing ALK-5/Smad2/3 signaling pathway
Keywords: Serelaxin; Cardiac fibroblasts; Myofibroblasts; Cardiac fibrosis; TGF-β1;
The KCa3.1 blocker TRAM-34 inhibits proliferation of fibroblasts in paraquat-induced pulmonary fibrosis
Keywords: PQ; paraquat; TGF-β1; transforming growth factor-β1; IPF; idiopathic pulmonary fibrosis; PBS; phosphate-buffered saline; BALF; bronchoalveolar lavage fluid; PVDF; polyvinylidene fluoride; TBST; Tris-buffered saline with Tween 20; α-SMA; α-smooth muscl
FASN-TGF-β1-PD-L1 axis contributes to the development of resistance to NK cell cytotoxicity of cisplatin-resistant lung cancer cells
Keywords: Fatty acid synthase (FASN); Cisplatin-resistant lung cancer; PD-L1; NK cells; TGF-β1;
Protective effects of dioscin against fructose-induced renal damage via adjusting Sirt3-mediated oxidative stress, fibrosis, lipid metabolism and inflammation
Keywords: BUN; blood urea nitrogen; Cr; creatinine; α-SMA; α-smooth muscle actin; COL1A1; collagen α1 (I); COL3A1; collagen α1 (III); TNF-α; tumor necrosis factor-alpha; IL-1β; interleukin-1β; IL-6; interleukin-6; TG; triglycerides; TC; total cholesterol; FF
TGF-β1 acts as mediator in fluoride-induced autophagy in the mouse osteoblast cells
Keywords: Autophagy; Fluoride; Mouse osteoblast cell; Proliferation; TGF-β1; ANOVA; one-way analysis of variant; Atg; autophagy-related; BCA; Bicinchoninic Acid; DAPI; 4â²,6-diamidino-2-phenylindole; DMEM/F12; Dulbecco's Modified Eagle Medium/F12; ECL; Electro-Ch
TGF-β1 targets a microRNA network that regulates cellular adhesion and migration in renal cancer
Keywords: Renal cancer; TGF-β1; microRNA; miR-25-3p; Adhesion;
New methodologies to accurately assess circulating active transforming growth factor-β1 levels: implications for evaluating heart failure and the impact of left ventricular assist devices
Keywords: CAD; coronary artery disease; CHF; congestive heart failure; DCM; dilated cardiomyopathy; HF; heart failure; LV; left ventricle; LVAD; left ventricular-assist device; PAI-1; plasminogen activator inhibitor-1; SMCA; single-molecule counting assay; TGF-β1;
Assessment of the possible roles of SB-269970 versus ketanserin on carbon tetrachloride-induced liver fibrosis in rats: Oxidative stress/TGF-β1-induced HSCs activation pathway
Keywords: 5-HT; Serotonin; ALT; Alanine aminotransferase; AST; Aspartate aminotransferase; CAT; Catalase; CCl4; Carbon tetrachloride; ECM; Extracellular matrix; ELISA; Enzyme-linked immunosorbent assay; GSH; Reduced glutathione; MDA; Malondialdehyde; PINP; Procolla
Fucosyltransferase 2 induced epithelial-mesenchymal transition via TGF-β/Smad signaling pathway in lung adenocarcinaoma
Keywords: FUT2; Fucosyltransferase 2; EMT; epithelial-mesenchymal transition; LUAD; lung adenocarcinoma; GTs; glycosyltransferases; FUTs; fucosyltransferases; TGF-β1; transforming growth factor β1; TβRII; type II TGF-β receptor; RNAi-FUT2; RNA interference FUT2
Losartan prevents the imbalance between renal dopaminergic and renin angiotensin systems induced by fructose overload. l-Dopa/dopamine index as new potential biomarker of renal dysfunction
Keywords: Ang II; angiotensin II; AT1R; angiotensin II type 1 receptor; CrCl; creatinine clearance; D1R; dopamine sub-type 1 receptor; DA; dopamine; FENa; fractional sodium excretion; FO; fructose overload; GFR; glomerular filtration rate; IR; Insulin resistance; N
RNA sequence analysis reveals pathways and candidate genes associated with liver injury in a rat pancreatitis model
Keywords: Acute pancreatitis; Pancreatitis-associated liver injury (PALI); TLR4; TGF-β1; RNA sequence;
Adiponectin receptor agonist AdipoRon decreased ceramide, and lipotoxicity, and ameliorated diabetic nephropathy
Keywords: 8-epi-PGF2α; 8-epi-prostaglandin F2α; 8-OH-dG; 8-hydroxy-2-deoxyguanosine; ACC; Acetyl-CoA carboxylase; AdipoR1 and AdipoR2; Adiponectin receptors 1 and 2; AMPK; AMP-dependent kinase; CKD; Chronic kidney disease; COL IV; Type IV collagen; eNOS; Endothel
S1P promotes migration, differentiation and immune regulatory activity in amniotic-fluid-derived stem cells
Keywords: Sphingosine-1-phosphate; Amniotic Fluid Stem Cells; TGF-β1; Indoleamine 2; 3 dioxygenase;
Novel formononetin-7-sal ester ameliorates pulmonary fibrosis via MEF2c signaling pathway
Keywords: Formononetin-7-sal ester; Anti-pulmonary fibrosis; MEF2c; TGF-β1;
Ethnopharmacology, phytochemistry, and pharmacology of Chinese Salvia species: A review
Keywords: ACh; acetylcholine; AChE; acetylcholinesterase; AD; Alzheimer's disease; AST; aspartate transaminase; CAT; catalase; CCL4; carbon tetrachloride; CK; casein kinase; DMN; dimethylnitrosamine; DPPH; 2,2-diphenyl-1-picrylhydrazyl; GSH; glutathione; HPRI; hepa
PGE2 induces apoptosis of hepatic stellate cells and attenuates liver fibrosis in mice by downregulating miR-23a-5p and miR-28a-5p
Keywords: COX-2; cyclooxygenase-2; PGE2; prostaglandin E2; ALT; alanine transaminase; TGF-β1; transforming growth factor β1; BAX; Bcl-2-associated X protein; Bcl-xL; B-cell lymphoma-extra-large; α-SMA; alpha smooth muscle actin; COL1A1; collagen type I alpha 1;
Adipose-derived stem cells decrease pain in a rat model of oxaliplatin-induced neuropathy: Role of VEGF-A modulation
Keywords: Adipose stem cells; Chemotherapy-induced neuropathic pain; VEGF-A; VEGF165b; Bevacizumab; VEGF-R1; Intrathecal; TGF-β1; EGF; CMTMR; 5-(and 6)-(((4-chloromethyl)benzoyl)amino)tetramethylrhodamine; DRG; dorsal root ganglion; i.p.; intraperitoneal; i.t.; in
Knockdown of TGF-β1 expression in human umbilical cord mesenchymal stem cells reverts their exosome-mediated EMT promoting effect on lung cancer cells
Keywords: MSC; Lung cancer; Exosomes; TGF-β1; CM; conditioned medium; MSC-CM; MSC-derived conditioned medium; MSC-exo; MSC-derived exosomes; si-TGFβ1; TGF-β1 small interfering RNA; siNC-MSC-exo; negative control siRNA transfected MSC-derived exosomes; siTGFβ1-M
Sustained anti-inflammatory effects of TGF-β1 on microglia/macrophages
Keywords: bFGF; basic fibroblast growth factor; Contra; contralateral cortex; DAMPs; damage-associated molecular patterns; dpr; days post-reperfusion; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; HGF; hepatocyte growth factor; HMGB1; high mobility group box 1;
Dual non-viral gene delivery from microparticles within 3D high-density stem cell constructs for enhanced bone tissue engineering
Keywords: Hydroxyapatite; Mesenchymal stem cells; Bone regeneration; Scaffold-free constructs; Endochondral ossification; TGF-β1; BMP-2;
Astaxanthin: A mechanistic review on its biological activities and health benefits
Keywords: Astaxanthin (PubChem CID: 5368397); Beta-Carotene (PubChem CID: 5280489); Beta-Cryptoxanthin (PubChem CID: 5281235); Canthaxanthin (PubChem CID: 5281227); Lutein (PubChem CID: 5281243); Zeaxanthin (PubChem CID: 5280899); Alpha-Tocopherol (PubChem CID: 149
Exosomes and regenerative medicine: state of the art and perspectives
Keywords: adMSCs; adipose-derived MSCs; AIS; acute ischemic stroke; AKI; acute kidney injury; AMI; acute myocardial infarction; BMP-7; bone morphogenetic protein 7; CCl4; carbon tetrachloride; CDCs; cardiosphere-derived cells; CM; conditioned medium; CPCs; cardiac
Effect of a long-term treatment with metformin in dystrophic mdx mice: A reconsideration of its potential clinical interest in Duchenne muscular dystrophy
Keywords: DMD; Duchenne muscular dystrophy; DGC; dystrophin-associated glycoprotein complex; ECM; extracellular matrix; SIRT1; Sirtuin1; PGC-1α; peroxisome proliferator-activated receptor γ coactivator 1α; PPARγ; peroxisome proliferator-activated receptor γ; B
Clinical benefits and pharmacology of scutellarin: A comprehensive review
Keywords: Aβ; β-amyloid peptide; ACE; angiotensin-converting enzyme; AD; Alzheimer's disease; ADE; adverse drug effect; ADR; adverse drug reaction; AIF; apoptosis-inducing factor; Akt; protein kinase B or PKB; ALS; amyotrophic lateral sclerosis; AMPK; AMP-activat
Original ResearchRole of transforming growth factor-β1 in triple negative breast cancer patients
Keywords: TGF-β1; Triple negative breast cancer; Prognostic value; Retrospective study; Two-institutional;
TGF-β1 promotes Staphylococcus aureus adhesion to and invasion into bovine mammary fibroblasts via the ERK pathway
Keywords: TGF-β1; Bovine mammary fibroblast; Staphylococcus aureus; ERK;
Original contributionSignificance of positive and inhibitory regulators in the TGF-β signaling pathway in colorectal cancers
Keywords: SMAD4; PPM1A; TGF-β1; Colorectal cancer; Prognosis; Tissue microarray; Immunohistochemistry;
Osthole inhibits the expressions of collagen I and III through Smad signaling pathway after treatment with TGF-β1 in mouse cardiac fibroblasts
Keywords: Osthole; TGF-β1; Collagen I; Collagen III; Smad;
MicroRNA-181a and its target Smad 7 as potential biomarkers for tracking child acute lymphoblastic leukemia
Keywords: ALL; Acute lymphoblastic leukemia; AML; acute myeloid leukemia; CDKs; cyclin-dependent kinases; CLL; chronic lymphocytic leukemia; ELISA; enzyme linked immunosorbent assay; GSK3β; glycogen synthase kinase 3β; I-Smads; inhibitory Smads; qRT-PCR; quantita
Aucubin and its hydrolytic derivative attenuate activation of hepatic stellate cells via modulation of TGF-β stimulation
Keywords: AU; aucubin; AUG; aucubigenin; Col I; collagen I; Col III; collagen III; ECM; extracellular matrix; α-SMA; alpha smooth muscle actin; LX-2; human hepatic stellate cell; TGF-β1; transforming growth factor-β1; CTGF; connective tissue growth factor; MDA;
Original articleC-phycocyanin suppresses transforming growth factor-β1-induced epithelial mesenchymal transition in human epithelial cells
Keywords: C-phycocyanin; TGF-β1; Epithelial-to-mesenchymal transition; Cell proliferation; Epithelial cells;
Blocking TGF-β1 by P17 peptides attenuates gastric cancer cell induced peritoneal fibrosis and prevents peritoneal dissemination in vitro and in vivo
Keywords: Peritoneal carcinomatosis; Mesothelial cell; TGF-β1; Extracellular matrix; Stomach cancer;
Evaluation of serum fibrotic markers; CTGF, IL-17and TGF-β1 versus liver biopsy for detection of hepatic fibrosis in Egyptian patients with chronic hepatitis C
Keywords: HCV; Fibrosis; CTGF; IL-17; TGF-β1;
Knockout of immunoproteasome subunit β2i ameliorates cardiac fibrosis and inflammation in DOCA/Salt hypertensive mice
Keywords: Immunoproteasome subunit β2i; Deoxycorticosterone-acetate/salt; Cardiac fibrosis; Inflammation; NF-κB; TGF-β1;