کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10216979 | 1683384 | 2018 | 30 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Macrophages Promote Wound-Induced Hair Follicle Regeneration in a CX3CR1- and TGF-β1-Dependent Manner
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کلمات کلیدی
PBSdays postinjuryphosphorylated SmadpSmadd.p.i.HFSCLAPDTRTGF-β1Transforming growth factor β1 - تبدیل فاکتور رشد β1tumor necrosis factor-α - تومور نکروز عامل αdiphtheria toxin - توکسین دیفتریhair follicle stem cell - سلول های بنیادی فولیکول موTNF-α - فاکتور نکروز توموری آلفاHair follicle - فولیکول موPhosphate-buffered saline - محلول نمک فسفات با خاصیت بافریlatency-associated peptide - پپتید وابسته به زمان تاخیرDiphtheria Toxin Receptor - گیرنده توکسین دیفتری
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
امراض پوستی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Hair follicle stem cells are regulated by intrafollicular and extrafollicular niche signals. Appropriate hair follicle regeneration relies on the coordinated release and integration of these signals. How immune cells, particularly cutaneous macrophages, influence the hair follicle stem cell niche and regeneration is not well understood. We took advantage of wound-induced hair growth (WIHG) to explore the relationship between wound macrophages and hair follicle regeneration. First, we showed that WIHG is dependent on CD11b+F4/80+ macrophages at 7-11 days after injury. Next, using CX3CR1gfp/+:CCR2rfp/+ mice to capture the dynamic spectrum of macrophage phenotypes during wound healing, we showed that wound macrophages transition from a CX3CR1lo/med to a CX3CR1hi phenotype at the onset of WIHG. Finally, WIHG is abolished in mice deficient for CX3CR1, delayed with pharmacological inhibition of transforming growth factor-β receptor type 1, and rescued with exogenous transforming growth factor-β1. Overall, we propose a model in which transforming growth factor-β1 and CX3CR1 are critical for recruiting and maintaining the CCR2+CX3CR1hiLy6CloTNFα+ macrophages critical for stimulating WIHG.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Investigative Dermatology - Volume 138, Issue 10, October 2018, Pages 2111-2122
Journal: Journal of Investigative Dermatology - Volume 138, Issue 10, October 2018, Pages 2111-2122
نویسندگان
Waleed Rahmani, Yunan Liu, Nicole L. Rosin, Adrienne Kline, Eko Raharjo, Jessica Yoon, Jo Anne Stratton, Sarthak Sinha, Jeff Biernaskie,