کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8258683 | 1534612 | 2018 | 40 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
PGE2 induces apoptosis of hepatic stellate cells and attenuates liver fibrosis in mice by downregulating miR-23a-5p and miR-28a-5p
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کلمات کلیدی
p38COL1A1CDH1TRADDα-SMABcl-xLERK1BMP2CAV1FN1Collagen type I alpha 1APAF1B-cell lymphoma-extra-largePGE2ALTPCNACOX-2NAFLDMitogen-activated protein kinase 14miRNAsTGF-β1HSCE-cadherin - E-Cadherinalanine transaminase - آلانین ترانس آمینازalpha smooth muscle actin - آلفا آکتیو عضله صافProliferating Cell Nuclear Antigen - آنتیژن هسته ای تکثیر سلولیNon-alcoholic steatohepatitis - استئاتوهپاتیت غیرالکلیBax - باکسnon-alcoholic fatty liver disease - بیماری کبدی چربی غیر الکلیTransforming growth factor β1 - تبدیل فاکتور رشد β1Cyclooxygenase-2 - سیکلوکوکسیژناز2transcription factor 3 - فاکتور رونویسی 3Apoptotic Peptidase Activating Factor 1 - فاکتور فعال فعال پپتیدی آپوپتوزی 1fibronectin 1 - فیبرنکتین 1Fibrosis - فیبروز یا فساد الیافNash - نوشBcl-2-associated X protein - پروتئین X مرتبط با Bcl-2bone morphogenic protein 2 - پروتئین مورفولوژیک استخوان 2Prostaglandin E2 - پروستاگلاندین E2caveolin 1 - کاورلین 1Liver - کبد
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: PGE2 induces apoptosis of hepatic stellate cells and attenuates liver fibrosis in mice by downregulating miR-23a-5p and miR-28a-5p PGE2 induces apoptosis of hepatic stellate cells and attenuates liver fibrosis in mice by downregulating miR-23a-5p and miR-28a-5p](/preview/png/8258683.png)
چکیده انگلیسی
MicroRNAs (miRNAs), small noncoding RNAs modulating messenger RNA (mRNA) and protein expression, have emerged as key regulatory molecules in chronic liver diseases, whose end stage is hepatic fibrosis, a major global health burden. Pharmacological strategies for prevention or treatment of hepatic fibrosis are still limited, what makes it necessary to establish a better understanding of the molecular mechanisms underlying its pathogenesis. In this context, we have recently shown that cyclooxygenase-2 (COX-2) expression in hepatocytes restricts activation of hepatic stellate cells (HSCs), a pivotal event in the initiation and progression of hepatic fibrosis. Here, we evaluated the role of COX-2 in the regulation of a specific set of miRNAs on a mouse model of CCl4 and bile duct ligation (BDL)-induced liver fibrosis. Our results provide evidence that COX-2 represses miR-23a-5p and miR-28-5p expression in HSC. The decrease of miR-23a-5p and miR-28-5p expression promotes protection against fibrosis by decreasing the levels of pro-fibrogenic markers α-SMA and COL1A1 and increasing apoptosis of HSC. Moreover, we demonstrate that serum levels of miR-28-5p are decreased in patients with chronic liver disease. These results suggest a protective effect exerted by COX-2-derived prostanoids in the process of hepatofibrogenesis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease - Volume 1864, Issue 2, February 2018, Pages 325-337
Journal: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease - Volume 1864, Issue 2, February 2018, Pages 325-337
نویسندگان
Brea R., Motiño O., Francés D., GarcÃa-Monzón C., Vargas J., Fernández-Velasco M., Boscá L., Casado M., MartÃn-Sanz P., Agra N.,