دانلود مقالات ISI درباره Tki + ترجمه فارسی

Multiplex Ultrasensitive Genotyping of Patients with Non-Small Cell Lung Cancer for Epidermal Growth Factor Receptor (EGFR) Mutations by Means of Picodroplet Digital PCR

Keywords: NSCLC; non-small cell lung cancer; TKI; tyrosine kinase inhibitor; PFS; progression-free survival; SARMS; Scorpion Amplification Refractory Mutation System; dPCR; digital polymerase chain reaction; ddPCR; picodroplet dPCR; mCRC; metastatic colorectal ca

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Large Cell Neuroendocrine Carcinoma Transformation and EGFR-T790M Mutation as Coexisting Mechanisms of Acquired Resistance to EGFR-TKIs in Lung Cancer

Keywords: EGFR; epidermal growth factor receptor; LCNEC; large cell neuroendocrine carcinoma; NGS; next-generation sequencing; NSCLC; non-small cell lung cancer; SCLC; small cell lung cancer; TKI; tyrosine kinase inhibitor;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Treatment, outcome and quality of life of 1239 patients with advanced non-small cell lung cancer - final results from the prospective German TLK cohort study

Keywords: ALK; Anaplastic Lymphoma Kinase; BMI; body mass index; CCI; Charlson Comorbidity Index; CI; confidence interval; CR; complete response; CRISP; clinical research platform into molecular testing, treatment and outcome of non-small cell lung carcinoma patien

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

Inhibition du récepteur MET : un espoir dans la lutte contre les résistances aux thérapies ciblées ?

Keywords: Récepteur MET; Thérapie ciblée; TKI; Résistance primaire; Résistance secondaire; MET receptor; Targeted therapy; TKI; Resistance;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

CAR T-cell therapy for lung cancer and malignant pleural mesothelioma

Keywords: ACT; adoptive cell therapy; ADC; adenocarcinoma; ALK; anaplastic lymphoma kinase; CAF; cancer-associated fibroblast; CAR; chimeric antigen receptor; CEA; carcinoembryonic antigen; CTLA-4; cytotoxic T-lymphocyte associated protein 4; DNR; dominant negative

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

Hematologic neoplasms: Dendritic cells vaccines in motion

Keywords: DCs; dendritic cells; TAA; tumor-associated antigens; APC; antigen presenting cells; mDCs; myeloid dendritic cells; pDCs; plasmacytoid dendritic cells; HLA; human leukocyte antigen; Ag Antigens; abs antibodies; PBMCs; peripheral blood mononuclear cells; G

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

Original ResearchAddressing the best treatment for non-clear cell renal cell carcinoma: A meta-analysis of randomised clinical trials comparing VEGFR-TKis versus mTORi-targeted therapies

Keywords: Renal cell carcinoma; Non clear cell RCC; Papillary RCC; TKi; mTORi; Sunitinib; Everolimus;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

Management of tyrosine kinase inhibitors (TKI) side effects in differentiated and medullary thyroid cancer patients

Keywords: toxicity; TKI; thyroid carcinoma; management; hypertension; gastrointestinal;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2017 سفارش ترجمه

Cardiovascular Complications of Cancer Therapy

Keywords: cancer therapy; cardiovascular complication; hypertension; radiation therapy; thromboembolism; AF; atrial fibrillation; CAD; coronary artery disease; CTA; computed tomography angiography; DOAC; direct oral anticoagulant; DVT; deep vein thrombosis; ECG; el

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2017 سفارش ترجمه

Summary of the 2016 ESC Position Paper on cancer treatments and cardiovascular toxicity developed under the auspices of the ESC Committee for Practice Guidelines

Keywords: CVD; cardiovascular disease; HER2; human epidermal growth factor receptor 2; HF; heart failure; T-DM1; trastuzumab, pertuzumab, trastuzumab-emtansine; TKI; lapatinib; LV; left ventricular; ACE; angiotensin-converting enzyme (ACE) inhibitors; VEGF; vascula

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2017 سفارش ترجمه

Overcoming ABC transporter-mediated multidrug resistance: The dual role of tyrosine kinase inhibitors as multitargeting agents

Keywords: MDR; BCR-ABL inhibitors; EGFR inhibitors; VEGFR inhibitors; Drug combinations; ABC; ATP binding cassette; ADME-tox; absorption, distribution, metabolism, excretion, toxicity; AKT; v-akt murine thymoma viral oncogene homolog; ALL; acute lymphoblastic leuke

دانلود رایگان متن کامل مقاله ISI 19 صفحه سال انتشار : 2017 سفارش ترجمه

Radotinib induces high cytotoxicity in c-KIT positive acute myeloid leukemia cells

Keywords: AML; acute myeloid leukemia; TKI; tyrosine kinase inhibitor; BMCs; bone marrow cells; Radotinib (PubChem CID: 16063245); Radotinib; Acute myeloid leukemia; c-KIT; CD117; Cytotoxicity; Anti-leukemic activity;

دانلود رایگان متن کامل مقاله ISI 24 صفحه سال انتشار : 2017 سفارش ترجمه

Characterization of Liver Metastasis and Its Effect on Targeted Therapy in EGFR-mutant NSCLC: A Multicenter Study

Keywords: Epidermal growth factor receptor mutation; LM; Non-small-cell lung cancer; Risk factor; TKI;

دانلود رایگان متن کامل مقاله ISI 26 صفحه سال انتشار : 2017 سفارش ترجمه

The molecular basis for RET tyrosine-kinase inhibitors in thyroid cancer

Keywords: thyroid cancer; tyrosine kinase; targeted therapy; MEN; RET; TKI;

دانلود رایگان متن کامل مقاله ISI 30 صفحه سال انتشار : 2017 سفارش ترجمه

Comparative effect of imatinib and ponatinib on autophagy and miRNome in chronic myeloid leukemia

Keywords: TKI; tyrosine kinase inhibitor; CML; chronic myeloid leukemia; LSC; leukemia stem cells; WST-1; Water Soluble Tetrazolium-1; GFP; Green Florescent Protein; TR-FRET; Time-resolved Fluorescence Energy Transfer; LC3B; light chain 3 B; miRNA; Micro Ribonuclei

دانلود رایگان متن کامل مقاله ISI 38 صفحه سال انتشار : 2017 سفارش ترجمه

Successful treatment with weekly high-dose erlotinib against meningeal metastases from epidermal growth factor receptor (EGFR)-mutated lung adenocarcinoma

Keywords: BBB; blood-brain barrier; CNS; central nervous system; CT; computed tomography; ECOG; Eastern Cooperative Oncology Group; EGFR; epidermal growth factor receptor; MRI; magnetic resonance imaging; NSCLC; non-small cell lung cancer; TKI; tyrosine kinase in

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2016 سفارش ترجمه

Afatinib-associated Stevens-Johnson syndrome in an EGFR-mutated lung cancer patient

Keywords: SJS; NSCLC; TKI; Afatinib;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2016 سفارش ترجمه

Current Trial ReportRationale and Design for the LUME-Colon 1 Study: A Randomized, Double-Blind, Placebo-Controlled Phase III Trial of Nintedanib Plus Best Supportive Care Versus Placebo Plus Best Supportive Care in Patients With Advanced Colorectal Cance

Keywords: Angiogenesis; Colorectal; FGF; PDGF; TKI; VEGF;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2016 سفارش ترجمه

The “Mystique” of Acute Leukemia: MPAL-BAL-AUL-ALAL-aBLL-HAL-MLL: Initial presentation of MPAL as extramedullary neurological compromise; A case report and review of literature

Keywords: MPAL; (Multi Phenotypic Acute Leukemia); BAL; (Biphenotypic Acute Leukemia); AUL; (Acute Undifferentiated Leukemia); ALAL; (Acute Leukemia of Ambiguous Lineage); HAL; (Hybrid Acute Leukemia); MLL; (Mixed Lineage Leukemia); aBLL; (acute BiLineal Leukemia);

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2016 سفارش ترجمه

Liquid chromatography-tandem mass spectrometric assay for ponatinib and N-desmethyl ponatinib in mouse plasma

Keywords: ALL; acute lymphoblastic leukemia; BCR-ABL; breakpoint cluster region-Abelson murine leukemia viral oncogene homolog; CML; chronic myeloid leukemia; CYP3A4; cytochrome P450 3A4; DMP; N-desmethyl ponatinib; ESI; electrospray Ionization; FVB; friend leukemi

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2016 سفارش ترجمه

EGFR mutation status on brain metastases from non-small cell lung cancer

Keywords: EGFR; Lung cancer; Brain metastases; Chemotherapy; TKI;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

Nowe metody diagnostyczne w prognozowaniu i śledzeniu odpowiedzi na leczenie inhibitorami kinaz tyrozynowych przewlekłej białaczki szpikowej

Keywords: CML; IKT; halving time; monitorowanie leczenia; digital PCRCML; TKI; Halving time; Treatment response monitoring; Digital PCR

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

A randomized, double-blind, phase II study of ramucirumab plus docetaxel vs placebo plus docetaxel in Japanese patients with stage IV non-small cell lung cancer after disease progression on platinum-based therapy

Keywords: AE; adverse event; CI; confidence interval; CR; complete response; CT; computed tomography; DCR; disease control rate; ECOG; Eastern Cooperative Oncology Group; EGFR; epidermal growth factor receptor; FAS; full analysis set; HR; hazard ratio; ILD; interst

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

Synergistic inhibition of sunitinib and ethaselen against human colorectal cancer cells proliferation

Keywords: TKI; tyrosine kinase inhibitor; VEGFRs; vascular endothelial growth factor receptors; PDGFRs; platelet-derived growth factor receptors; NSCLC; non-small cell lung cancer; Trx; thioredoxin; TrxR; thioredoxin reductase; BBSKE; ethaselen; ROS; reactive oxyge

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

Five-Year Survival in EGFR-Mutant Metastatic Lung Adenocarcinoma Treated with EGFR-TKIs

Keywords: Non-small cell lung cancer; EGFR; TKI; long-term survival;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

Regulation of the ErbB network by the MIG6 feedback loop in physiology, tumor suppression and responses to oncogene-targeted therapeutics

Keywords: RTK; receptor tyrosine kinase; EGF; epidermal growh factor; EGFR; epidermal growth factor receptor; LRIG1; leucin-rich repeats and immunoglobulin-like domains1; MIG; 6mitogen inducible gene 6; RALT; receptor associated late transducer; ERRFI1; ErbB recept

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

Is sunitinib a Narrow Therapeutic Index Drug? - A systematic review and in vitro toxicology-analysis of Sunitinib vs. Imatinib in cells from different tissues

Keywords: Apoptosis; Drug safety; Imatinib; Narrow Therapeutic Index Drug (NTID); Receptor tyrosine kinase (RTK); Sunitinib; Toxicity; Tyrosine kinase inhibitor (TKI); Cell viability; ALL; acute lymphoblastic leukemia; AUC; area under the curve; b.i.d.; twice daily

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

Outcomes of chemotherapies and HER2 directed therapies in advanced HER2-mutant lung cancers

Keywords: TKI; tyrosine kinase inhibitors; HER2; human epidermal growth factor receptor 2; Human epidermal growth factor receptor 2 (HER2); Mutation; Lung cancer; Chemotherapy; Targeted therapy;

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2016 سفارش ترجمه

The impact of Organic Anion-Transporting Polypeptides (OATPs) on disposition and toxicity of antitumor drugs: Insights from knockout and humanized mice

Keywords: ABC; ATP-binding cassette; AUC; area under the concentration-time curve; DDI; drug-drug interactions; E2G; estradiol 17β-d-glucuronide; i.v.; intravenous; OATP; organic anion-transporting polypeptide; TKI; tyrosine kinase inhibitor; UGT1A1; UDP-glucuro

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2016 سفارش ترجمه

Outcome and Safety of Sorafenib in Metastatic Renal Cell Carcinoma Dialysis Patients: A Systematic Review

Keywords: Hemodialysis; RCC; Renal failure; TKI; Treatment;

دانلود رایگان متن کامل مقاله ISI 26 صفحه سال انتشار : 2016 سفارش ترجمه

Prognostic Value of SETD2 Expression in Patients with Metastatic Renal Cell Carcinoma Treated with Tyrosine Kinase Inhibitors

Keywords: carcinoma; renal cell; neoplasm metastasis; survival; disease-free survival; biomarkers; ccRCC; clear cell renal cell carcinoma; IHC; immunohistochemistry; IRS; immunoreactivity score; mRCC; metastatic renal cell carcinoma; OS; overall survival; PFS; prog

دانلود رایگان متن کامل مقاله ISI 35 صفحه سال انتشار : 2016 سفارش ترجمه

Epidermal growth factor receptor inhibitor cancer drug gefitinib modulates cell growth and differentiation of acute myeloid leukemia cells via histamine receptors

Keywords: 4-MH; 4-methylhistamine; AML; acute myelogenous leukemia; CML; chronic myelogenous leukemia; cAMP; cyclic adenosine monophosphate; CRE; cAMP response element; EGFR; epidermal growth factor receptor; ER; estrogen receptor alpha; FSK; Forskolin; GPCR; G-pro

دانلود رایگان متن کامل مقاله ISI 40 صفحه سال انتشار : 2016 سفارش ترجمه

EGFR Testing in Advanced Non-Small-Cell Lung Cancer, A Mini-Review

Keywords: Adenocarcinoma; Afatinib; Erlotinib; Exon 19; Gefitinib; L858R; Osimertinib; TKI; T790M;

دانلود رایگان متن کامل مقاله ISI 41 صفحه سال انتشار : 2016 سفارش ترجمه

Neratinib shows efficacy in the treatment of HER2 amplified carcinosarcoma in vitro and in vivo

Keywords: Carcinosarcoma; HER2/neu; TKI; Targeted therapy; ErbB2

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

Rationale and Study Design of the IRENE-Trial (NVALT-16): A Phase II Trial to Evaluate Iressa Rechallenge in Advanced NSCLC Patients With an Activating EGFR Mutation Who Responded to an EGFR-TKI Used As First-Line or Previous Treatment

Keywords: Drug holiday; EGFR; NSCLC; TKI; TKI-resistance

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

Expression of insulin-like growth factor 1 receptor (IGF-1R) predicts poor responses to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors in non-small cell lung cancer patients harboring activating EGFR mutations

Keywords: IGF-1R; EGFR mutation; TKI; DM; Non-small cell lung cancer; Progression-free survival

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

ErbB small molecule tyrosine kinase inhibitor (TKI) induced diarrhoea: Chloride secretion as a mechanistic hypothesis

Keywords: TKI; Mucositis; Diarrhoea; Chloride secretion; ErbB (EGFR, HER)

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

ALK-FISH borderline cases in non-small cell lung cancer: Implications for diagnostics and clinical decision making

Keywords: ADC; adenocarcinoma; ADSC; adenosquamous carcinoma; ALK; anaplastic lymphoma kinase; BL; borderline; CNG; copy number gain; EMA; European Medicines Agency; FDA; Food and Drug Administration; FISH; fluorescence in-situ hybridization; FS; fused signals; FN;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

Synthesis and biological evaluation of di-aryl urea derivatives as c-Kit inhibitors

Keywords: ATP; adenosine 5′-triphosphate; CML; chronic myeloid leukemia; EGFR; epidermal growth factor receptor; FC; flash chromatography; GIST; gastrointestinal stromal tumor; MAPK; mitogen activated protein kinase; PDGFR; platelet-derived growth factor receptor

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

SALL4: An emerging cancer biomarker and target

Keywords: ESCs; embryonic stem cells; AML; acute myeloid leukemia; CSCs; cancer stem cells; iPS; induced pluripotent stem cell; HSCs/HPCs; hematopoietic stem/progenitor cells; MDS; myelodysplastic syndrome; LSCs; leukemic stem cells; CML; chronic myeloid leukemia;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

The challenge of blocking a wider family members of EGFR against head and neck squamous cell carcinomas

Keywords: Afatinib; Personalised therapy; EGFR; ErbB; TKI; HPV; EBV; P16; Head and neck squamous cell carcinoma;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

Research ArticleSorafenib inhibits macrophage-induced growth of hepatoma cells by interference with insulin-like growth factor-1 secretion

Keywords: HCC; hepatocellular carcinoma; TAM; tumor associated macrophages; M1; classical polarized macrophages; M2; alternative polarized macrophages; EGF; epidermal growth factor; VEGF; vascular endothelial growth factor; IGF-1; insulin-like growth factor-1; TKI;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

Impact of Smoking Status on EGFR-TKI Efficacy for Advanced Non-Small-Cell Lung Cancer in EGFR Mutants: A Meta-analysis

Keywords: EGFR mutation; Meta-analysis; Non-small-cell lung cancer; Smoking; TKI;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Comparison of outcomes of idarubicin intensified TBI-CY and traditional TBI-CY conditioning regimen for high-risk acute lymphoblastic leukemia undergoing allogeneic hematopoietic stem cell transplantation: A single center experience

Keywords: ALL; acute lymphoblastic leukemia; allo-HSCT; allogeneic hematopoietic stem cell transplantation; TRM; transplant-related mortality; IDA; idarubicin; HR; hazard ratio; CI; confidence interval; NR; no remission; TBI; total body irradiation; CY; cyclophosph

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Calcitriol and its analogues enhance the antiproliferative activity of gefitinib in breast cancer cells

Keywords: CK-7; cytokeratin 7; EGFR; epidermal growth factor receptor; ERK; extracellular signal-regulated kinase; FSC-A; forward scatter area; FSC-H; forward scatter height; GI; growth inhibitory; HER2; epidermal growth factor receptor type II; IC; inhibitory conc

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Dopamine D2 receptor agonists inhibit lung cancer progression by reducing angiogenesis and tumor infiltrating myeloid derived suppressor cells

Keywords: Dopamine; Lung cancer; VEGF; Cabergoline; Angiogenesis; Dopamine D2 receptor agonists; D2R; dopamine D2 receptor; LLC1; Lewis lung carcinoma 1; NSCLC; non-small cell lung cancer; VEGF; vascular endothelial growth factor A; EGFR; epidermal growth factor re

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2015 سفارش ترجمه

Vorinostat synergizes with EGFR inhibitors in NSCLC cells by increasing ROS via up-regulation of the major mitochondrial porin VDAC1 and modulation of the c-Myc-NRF2-KEAP1 pathway

Keywords: AREs; Antioxidant response elements; CI; Combination index; DRI; Dose reduction index; EGFR; Epidermal growth factor receptor; EMT; Epithelial-to-mesenchymal transition; GSK3β; Glycogen synthase kinase 3β; HDACi; Histone deacetylase inhibitor; HK1; Hexo

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2015 سفارش ترجمه

FGFR as potential target in the treatment of squamous non small cell lung cancer

Keywords: NSCLC; Squamous cell carcinoma; FGF; FGFR; TKI

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2015 سفارش ترجمه

Should Tyrosine Kinase Inhibitors Be Considered for Advanced Non-Small-Cell Lung Cancer Patients With Wild Type EGFR? Two Systematic Reviews and Meta-Analyses of Randomized Trials

Keywords: Chemotherapy; Meta-analysis; NSCLC; RCT; TKI;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2015 سفارش ترجمه

HER family kinase domain mutations promote tumor progression and can predict response to treatment in human breast cancer

Keywords: HER family mutation; Kinase domain; Lapatinib; Drug resistance; Biomarker; TKI; tyrosine kinase inhibitors;

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2015 سفارش ترجمه