دانلود مقالات ISI درباره Tki + ترجمه فارسی

Brain accumulation of the EML4-ALK inhibitor ceritinib is restricted by P-glycoprotein (P-GP/ABCB1) and breast cancer resistance protein (BCRP/ABCG2)

Keywords: ABC; ATP-binding cassette; ALK; anaplastic lymphoma kinase; AUC; area under the plasma concentration-time curve; BBB; blood-brain barrier; BCRP; breast cancer resistance protein; Cmax; maximum drug concentration in plasma; EML4; echinoderm microtubule-ass

دانلود رایگان متن کامل مقاله ISI 24 صفحه سال انتشار : 2015 سفارش ترجمه

A population-based review of the feasibility of platinum-based combination chemotherapy after tyrosine kinase inhibition in EGFR mutation positive non-small cell lung cancer patients with advanced disease

Keywords: EGFR; Chemotherapy; Second-line; Gefitinib; TKI; Population-based;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2014 سفارش ترجمه

Selection of DNA aptamers against epidermal growth factor receptor with high affinity and specificity

Keywords: EGFR; epidermal growth factor receptor; SELEX; systematic evolution of ligands by exponential enrichment; RPTK; receptor protein tyrosine kinase; NSCLC; non-small-cell lung carcinoma; TKI; tyrosine kinase inhibitors; VEGF; vascular endothelial growth fact

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2014 سفارش ترجمه

Targeting of the MET receptor tyrosine kinase by small molecule inhibitors leads to MET accumulation by impairing the receptor downregulation

Keywords: RTK; receptor tyrosine kinase; TKI; tyrosine kinase inhibitor; HGF; hepatocyte growth factor; wt; wild type; TKB; tyrosine kinase binding; MET; Small molecule tyrosine kinase inhibitor; Receptor downregulation; CBL; Receptor ubiquitination; MET Tyr1003;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

The multikinase inhibitor axitinib is a potent inhibitor of human CYP1A2

Keywords: LC-MS/MS; liquid chromatography-tandem mass spectrometry; MKI; multikinase inhibitor; SRS; substrate recognition sequence; TKI; tyrosine kinase inhibitor; Axitinib; Cytochrome P450; CYP1A2 inhibitor; Molecular modeling; Multikinase inhibitor; 7-Ethoxy

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

A calpain-cleaved fragment of β-catenin promotes BCRABL1 + cell survival evoked by autophagy induction in response to imatinib

Keywords: ULK1; unc-51-like kinase; ATG; autophagy-related proteins; FIP200; focal adhesion interacting protein 200; PI3K; class III phosphoinositide 3-kinase; Vps; vacuolar protein sorting; LC3; microtubule-associated protein 1 light chain 3; PE; phosphatidylethan

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Randomized Phase II Open-Label Study of mFOLFOX6 in Combination With Linifanib or Bevacizumab for Metastatic Colorectal Cancer

Keywords: ABT-869; Advanced colorectal cancer; Colon cancer; Second-line; TKI;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

From mice to men: GEMMs as trial patients for new NSCLC therapies

Keywords: AdCre; adenovirus Cre recombinase; ALK; anaplastic lymphoma kinase; ANGPTL3; angiopoietin-like 3; Ccsp; Clara cell secretory protein; GEMMs; genetically engineered mouse models; HSP; heat shock family; IN; intranasal; LentiCre; lentivirus Cre recombinase;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

Prognostic Significance of Cytoreductive Nephrectomy in Patients With Synchronous Metastases From Renal Cell Carcinoma Treated With First-Line Sunitinib: A European Multiinstitutional Study

Keywords: Metastatic; Prognosis; Renal cancer; Surgery; TKI

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2014 سفارش ترجمه

Motesanib (AMG706), a potent multikinase inhibitor, antagonizes multidrug resistance by inhibiting the efflux activity of the ABCB1

Keywords: MDR; multidrug resistance; ABC; ATP-binding cassette; ABCB1; ABC transporter subfamily B member 1; ABCG2; ABC transporter subfamily G member 2; VEGFR; vascular endothelial growth factor receptor; TKI; tyrosine kinase inhibitor; Multidrug resistance; ABC t

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2014 سفارش ترجمه

Secretory Hyperresponsiveness and Pulmonary Mucus Hypersecretion

Keywords: BAC; bronchoalveolar carcinoma; BHR; bronchial hyperresponsiveness; CDA; cough-dominant asthma; CF; cystic fibrosis; EGFR; epidermal growth factor receptor; ERK; extracellular-regulated kinase; LPS; lipopolysaccharide; MEC; mucoepidermoid carcinoma; MLS;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2014 سفارش ترجمه

Biological, diagnostic and therapeutic relevance of the MET receptor signaling in head and neck cancer

Keywords: Head and neck cancer; MET receptor tyrosine kinase; Targeted therapy; Prognostic impact; Treatment resistance; CSC; cancer stem-like cell; DDR; DNA damage response; ECM; extracellular matrix; EGFR; epidermal growth factor receptor; Egr-1; early growth res

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2014 سفارش ترجمه

CEP-33779 antagonizes ATP-binding cassette subfamily B member 1 mediated multidrug resistance by inhibiting its transport function

Keywords: ABC; ATP-binding cassette; ABCC1; multidrug resistance-associated protein 1; ABCG2; breast cancer resistance protein; CSCs; Cancer stem cell; DOX; doxorubicin; FTC; fumitremorgin C; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; Rho123; Rhodamine 123; M

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2014 سفارش ترجمه

Prevention of BMS-777607-induced polyploidy/senescence by mTOR inhibitor AZD8055 sensitizes breast cancer cells to cytotoxic chemotherapeutics

Keywords: Breast cancer; Receptor tyrosine kinase; Small molecule inhibitor; Senescence; Polyploidy; mTOR signaling; Chemosensitivity; AXL; Greek word anexelekto; BCR; breakpoint cluster region; BRAF; B-Rapidly Accelerated Fibrosarcoma; DAPI; 4′,6′-diamidino-2-

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2014 سفارش ترجمه

Establishment of a human 3D lung cancer model based on a biological tissue matrix combined with a Boolean in silico model

Keywords: 3D tumor model; Boolean model; EMT; Invasion; Personalized medicine; Targeted therapy; BioVaSc; Biological Vascularized Scaffold; EGFR; epidermal growth factor receptor; EMT; epithelial-mesenchymal transition; MUC1; mucin-1; PI; proliferation index; TGF

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2014 سفارش ترجمه

Histone deacetylase inhibitor (HDACI) mechanisms of action: Emerging insights

Keywords: HDAC inhibitor; DNA damage response; DNA repair; Cell cycle checkpoints; Apoptosis; Rational combinations; ALL; acute lymphoblastic leukemia; AML; acute myeloid leukemia; APAF-1; apoptotic protease activating factor 1; ASK1; apoptosis signal-regulating ki

دانلود رایگان متن کامل مقاله ISI 78 صفحه سال انتشار : 2014 سفارش ترجمه

High-dose, pulsatile erlotinib in two NSCLC patients with leptomeningeal metastases-One with a remarkable thoracic response as well

Keywords: Lung cancer; Leptomeningeal metastases; Erlotinib; EGFR; Pulsatile dosing; TKI;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2013 سفارش ترجمه

Ponatinib is a potent inhibitor of wild-type and drug-resistant gatekeeper mutant RET kinase

Keywords: CML; chronic myeloid leukemia; ALL; acute lymphoblastic leukemia; RET; REarranged during Transfection; GDNF; glial-derived neurotrophic factor; TKI; tyrosine kinase inhibitor; MTC; medullary thyroid carcinoma; FMTC; familial MTC; PTC; papillary thyroid ca

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Differential response to 1α,25-dihydroxyvitamin D3 (1α,25(OH)2D3) in non-small cell lung cancer cells with distinct oncogene mutations

Keywords: Non-small cell lung cancer; Vitamin D receptor; 1,25-Dihydroxyvitamin D3; Epidermal growth factor receptor; K-ras; CSS; charcoal-stripped serum; DMSO; dimethylsulfoxide; EGFR; epidermal growth factor receptor; FBS; fetal bovine serum; 1,25(OH)2D3; 1,25-di

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Original studySimilar Outcome of Patients With Chronic Myeloid Leukemia Treated With Imatinib in or Out of Clinical Trials

Keywords: CML; Imatinib; Outside of a clinical trial; Prognosis; TKI;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Adequacy of CT-guided biopsies with histomolecular subtyping of pulmonary adenocarcinomas: Influence of ATS/ERS/IASLC guidelines

Keywords: TTNB; Trans-Thoracic Needle core Biopsy; ALK; Anaplastic Lymphoma Kinase; FISH; Fluorescent In Situ Hybridization; CISH; Chromogenic In Situ Hybridization; EGFR; Epidermal Growth Factor Receptor; TKI; Tyrosine Kinase Inhibitor; FNA; Fine Needle Aspiration

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Sustained EKR inhibition by EGFR targeting therapies is a predictive factor for synergistic cytotoxicity with PDT as neoadjuvant therapy

Keywords: EGFR; epidermal growth factor receptor; ERK; extracellular signal-regulated kinase; MTT; 1-(4,5-Dimethylthiazol-2-yl)-3,5-diphenylformazan; PDT; photodynamic therapy; TKI; tyrosine kinase inhibitor; mAb; monoclonal antibody; TPPS2a; meso-tetraphenylporphi

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2013 سفارش ترجمه

EGFR-tyrosine kinase inhibitor treatment beyond progression in long-term Caucasian responders to erlotinib in advanced non-small cell lung cancer: A case-control study of overall survival

Keywords: AC; adenocarcinoma; BSC; best supportive care; CI; 95% confidence interval; EGFR; epidermal growth factor receptor; EGFRM; EGFR mutation; HR; hazard ratio; n.s.; not significant; NSCLC; non-small cell lung cancer; OS; overall survival; PFS; progression-fr

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Genetics and pharmacogenomics of diffuse gliomas

Keywords: Companion diagnostics; Glioma; 1p/19q co-deletion; IDH1; Pharmacogenomics; EGFRvIII; CGH; comparative genomic hybridization; CNA; copy number aberrations; CRC; colorectal carcinoma; CML; chronic myeloid leukemia; EGFR; epidermal growth factor receptor; FF

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2013 سفارش ترجمه

FGFR signalling in women's cancers

Keywords: FGF; fibroblast growth factor; FGFR; fibroblast growth factor receptor; HS; heparan sulfate; RTK; receptor tyrosine kinase; ER; oestrogen receptor; PR; progesterone receptor; IDC; invasive ductal carcinoma; FISH; fluorescence in situ hybridisation; TMA; t

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2013 سفارش ترجمه

Vitamin D in thyroid tumorigenesis and development

Keywords: 1,25(OH)2D3; 1α,25-dihydroxyvitamin D3; 25-OHD3; 25-hydroxyvitamin D3; ATC; anaplastic thyroid cancer; CDK; cyclin-dependent kinase; CDKI; cyclin-dependent kinase inhibitor; CEA; carcinoembryogenic antigen; CT; calcitonin; CYP24A1; 24-hydroxylase; CYP27B

دانلود رایگان متن کامل مقاله ISI 34 صفحه سال انتشار : 2013 سفارش ترجمه

Improvement in Overall Survival of Patients with Advanced Renal Cell Carcinoma: Prognostic Factor Trend Analysis from an International Data Set of Clinical Trials

Keywords: kidney; carcinoma, renal cell; neoplasm metastasis; risk; SEER program; ECOG; Eastern Cooperative Oncology Group; IFN; interferon-α; LDH; lactate dehydrogenase; mRCC; metastatic renal cell carcinoma; MSKCC; Memorial Sloan-Kettering Cancer Center; OS; ove

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

mTOR inhibitors in cancer therapy

Keywords: PI3K; phosphatidylinositol 3-kinase; mTOR; mammalian target of rapamycin; mTORC; mammalian target of rapamycin complex; Raptor; regulatory-associated protein of mTOR; S6K1; S6 kinase 1, 4E-BP1, 4E-binding protein 1; Rictor; rapamycin-insensitive companion

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Research ArticleEpidermal growth factor receptor and HER-3 restrict cell response to sorafenib in hepatocellular carcinoma cells

Keywords: HCC; hepatocellular carcinoma; EGFR; epidermal growth factor receptor; TKI; tyrosine kinase inhibitor; PARP; polyADP-ribose polymerase; HPRT; hypoxanthine phosphoribosyltransferase; EGFR; HER-3/ErbB-3; Amphiregulin; Gefitinib; ERK;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Activation of Multiple ERBB Family Receptors Mediates Glioblastoma Cancer Stem-like Cell Resistance to EGFR-Targeted Inhibition

Keywords: GBM; glioblastoma multiforme; CSC; cancer stem-like cell; NSC; neural stem cell; GFAP; glial fibrillary acidic protein; EGF; epidermal growth factor; EGFR; epidermal growth factor receptor; ERBB2 and ERBB3; v-erb-b erythroblastic leukemia viral oncogene h

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2012 سفارش ترجمه

Immune response modifiers in the treatment of asthma: A PRACTALL document of the American Academy of Allergy, Asthma & Immunology and the European Academy of Allergy and Clinical Immunology

Keywords: Immune response modifiers; monoclonal antibodies; asthma; allergic diseases; APC; Antigen-presenting cell; CRTH2; Chemoattractant receptor-homologous molecule expressed on TH2 cells (also known as DP2); FDA; US Food and Drug Administration; Feno; Fraction

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2012 سفارش ترجمه

Expression of selected gene for acquired drug resistance to EGFR-TKI in lung adenocarcinoma

Keywords: EGFR; epidermal growth factor receptor; TKI; tyrosine kinase inhibitor; EMT; epithelial-mesenchymal transition; T790M; threonine-to-methionine mutation at codon 790 of EGFR; p-MET; phosphorylation of MET; p-Akt; phosphorylation of Akt; IHC; immunohistoc

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2011 سفارش ترجمه

Good response to pemetrexed in patients of lung adenocarcinoma with epidermal growth factor receptor (EGFR) mutations

Keywords: EGFR; epidermal growth factor receptor; TKI; tyrosine kinase inhibitor; NSCLC; non-small cell lung cancer; MPE; malignant pleural effusion; CXR; chest radiography; CT; computed tomography; MRI; magnetic resonance imaging; del; deletion; ins; insertion; Pe

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

Glyoxalase in tumourigenesis and multidrug resistance

Keywords: AGE; advanced glycation endproduct; ALL; acute lymphoid leukaemia; AML; acute myeloid leukaemia; BBGD; S-p-bromobenzylglutathione cyclopentyl diester; CEdG; N2-(1-carboxyethyl)-deoxyguanosine; CEL; Nɛ-carboxyethyl-lysine; CrML; chronic myeloid leukaemia;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

Cardiotoxicity of novel molecular targeted therapies of cancer

Keywords: Cardiotoxicity; TKIs; Cardiomyocite; VEGF; PDGF; Cardiotossicità; TKI; Cardiomiocita; VEGF; PDGF;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

Combining an EGFR directed tyrosine kinase inhibitor with autophagy-inducing drugs: A beneficial strategy to combat non-small cell lung cancer

Keywords: NSCLC; TKI; Erlotinib; Rapamycin; Autophagy

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه

Targeting autophagy during cancer therapy to improve clinical outcomes

Keywords: AMPK; AMP activated protein kinase; ATG; autophagy-related genes; Bif-1; endophilin B1; BNIP3; Bcl-2/adenovirus E1B 19 kDa-interacting protein; CML; chronic myeloid leukemia; CQ; chloroquine; DAP1; death-associated protein 1; HCQ; hydroxychloroquine; HDA

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2011 سفارش ترجمه

Effect of gefitinib on the survival of patients with recurrence of lung adenocarcinoma after surgery: A retrospective case-matching cohort study

Keywords: Lung cancer; EGFR mutation; TKI; Gefitinib; Survival benefit

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2010 سفارش ترجمه

Contemporary Management of Renal Tumors With Venous Tumor Thrombus

Keywords: carcinoma; renal cell; kidney neoplasms; neoplasm invasiveness; CPBP; cardiopulmonary bypass procedure; CT; computerized tomography; DHCA; deep hypothermia circulatory arrest; DSS; disease specific survival; ECOG; Eastern Cooperative Oncology Group; IVC;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2010 سفارش ترجمه

New strategies to overcome limitations of reversible EGFR tyrosine kinase inhibitor therapy in non-small cell lung cancer

Keywords: NSCLC; EGFR; HER; T790M; Irreversible; TKI; Antibody

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2010 سفارش ترجمه

Chronic myeloid leukemia in the Asia-Pacific region: Current practice, challenges and opportunities in the targeted therapy era

Keywords: Asia; Clinical practice; CML; Imatinib; Management; Survey; TKI

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2010 سفارش ترجمه

BCR-ABL tyrosine kinase inhibitors in the treatment of Philadelphia chromosome positive chronic myeloid leukemia: A review

Keywords: CML; Philadelphia chromosome; TKI; BCR-ABL;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2010 سفارش ترجمه

Predictors of Survival of Advanced Renal Cell Carcinoma: Long-Term Results From Southwest Oncology Group Trial S8949

Keywords: kidney; carcinoma; renal cell; inteferons; nephrectomy; mortality; RCC; renal cell carcinoma; SWOG; Southwest Oncology Group; TKI; tyrosine kinase inhibitor;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2009 سفارش ترجمه

Suboptimal Response to or Failure of Imatinib Treatment for Chronic Myeloid Leukemia: What Is the Optimal Strategy?

Keywords: CCyR; complete cytogenetic response; CHR; complete hematologic response; CML; chronic myeloid leukemia; CP; chronic phase; ELN; European LeukemiaNet; IRIS; International Randomized Study of Interferon vs STI571; MCyR; major cytogenetic response; MMR; majo

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2009 سفارش ترجمه

New targets for Ph+ leukaemia therapy

Keywords: BCR-ABL; new targets; GEP; resistance; TKI; Aurora kinases; Smo inhibitors; GSK3β splicing

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2009 سفارش ترجمه

ANXA8 Down-regulation by EGF-FOXO4 Signaling Is Involved in Cell Scattering and Tumor Metastasis of Cholangiocarcinoma

Keywords: CC; cholangiocarcinoma; EGFR; epidermal growth factor receptor; EMT; epithelial-to-mesenchymal transition; FAK; focal adhesion kinase; PI3K; phosphatidylinositol-3-kinase; TKI; tyrosine kinase inhibitor;

دانلود رایگان متن کامل مقاله ISI 22 صفحه سال انتشار : 2009 سفارش ترجمه

Management of toxicity in patients treated with tyrosine kinase inhibitors (TKI)

Keywords: Toxicity; TKI; Renal;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2008 سفارش ترجمه

Sorafenib in Lung Cancer: Clinical Developments and Future Directions

Keywords: NSCLC; TKI; Proangiogenic; VEGFR; Raf kinase;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2008 سفارش ترجمه

The Tyrosine Kinase Inhibitor Cediranib for Non-small Cell Lung Cancer and Other Thoracic Malignancies

Keywords: AZD2171; TKI; NSCLC; angiogenesis inhibitor

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2008 سفارش ترجمه

A cell-based high-throughput screen for epidermal growth factor receptor pathway inhibitors

Keywords: EGFR; 32D cell line; HTS; NSCLC; TKI;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2008 سفارش ترجمه