Control of a tumor suppressor PDCD4: Degradation mechanisms of the protein in hepatocellular carcinoma cells
Keywords: EGF; TGF-β1; TPA; PDCD4; Apoptosis; Huh7 hepatoma cells;
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Differential involvement of signaling pathways in the regulation of growth hormone release by somatostatin and growth hormone-releasing hormone in orange-spotted grouper (Epinephelus coioides)
Keywords: GH; growth hormone; SRIF; somatotropin release-inhibitory factor; GHRH; GH-releasing hormone; PACAP; pituitary adenylate cyclase-activating peptide; DA; dopamine; GnRH; gonadotropin-releasing hormone; GPCR; G-protein-coupled receptor; SSTR; somatostatin r
PGD2 DP1 receptor stimulation following stroke ameliorates cerebral blood flow and outcomes
Keywords: CBF; cerebral blood flow; LDF; laser-Doppler flowmetry; MCA; middle cerebral artery; MCAO; middle cerebral arterial occlusion; NMDA; N-methyl-d-aspartate; PGD2; prostaglandin D2; tPA; tissue plasminogen activator; TTC; 2,3,5-triphenyl-tetrazolium chloride
A detailed analysis of partial molecular volumes in DPPC/cholesterol binary bilayers
Keywords: DPPC; 1,2-dipalmitoyl-sn-glycero-3-phosphocholine; Ld; liquid-disordered; Lo; liquid-ordered; D2O; deuterium oxide; tPA; trans-parinaric acid; DPPC/cholesterol binary bilayer; Buoyant density measurement; Fluorescence decay; Liquid-ordered phase; Partial
Matrikines from basement membrane collagens: A new anti-cancer strategy
Keywords: ECM; extracellular matrix; MMP; matrix metalloproteinases; SDF-1; Stroma-Derived Factor 1; CAFs; cancer-Associated Fibroblasts; ROS; reactive oxygen species; EMT; epithelial-mesenchymal transition; NC domain; non-collagenous domain; FACIT; fibril associ
Nuclear translocation of CBP/p300-interacting protein CITED1 induced by parathyroid hormone requires serine phosphorylation at position 79 in its 63-84 domain
Keywords: CITED1; CBP/p300-interacting protein; PTH; parathyroid hormone; RANKL; receptor activator of nuclear factor kappa-B ligand; cAMP; cyclic adenosine monophosphate; msg-1; melanoma specific growth gene 1; TGF β; transforming growth factor beta; ALP; alkalin
Aging causes exacerbated ischemic brain injury and failure of sevoflurane post-conditioning: Role of B-cell lymphoma-2
Keywords: Bax; Bcl-2-associated X protein; Bcl-2; B-cell lymphoma-2; ECL; enhanced chemiluminescence; MAPK; mitogen-activated protein kinase; MCAO; middle cerebral artery occlusion; STAT3; signal transducer and activator of transcription-3; tPA; tissue plasminogen
Genotoxic potential and in vitro tumour-promoting potential of 2-dodecylcyclobutanone and 2-tetradecylcyclobutanone, two radiolytic products of fatty acids
Keywords: 2-ACBs; 2-alkylcyclobutanones; 2-dDCB; 2-dodecylcyclobutanone; 2-tDCB; 2-tetradecylcyclobutanone; 2-tDeCB; 2-(tetradec-5â²-enyl)-cyclobutanone; AOM; azoxymethane; SA; stearic acid; PA; palmitic acid; AF-2; 2-(2-furyl)-3-(5-nitro-2-furyl) acrylamide; 2AA;
MiR-139-5p inhibits HGTD-P and regulates neuronal apoptosis induced by hypoxia-ischemia in neonatal rats
Keywords: HGTD-P; human growth transformation dependent protein; HIBD; hypoxia-ischemia brain damage; OGD; oxygen-glucose deprivation; HI; hypoxia-ischemia; AIF; apoptosis inducible factor; RISC; RNA-induced silencing complex; 3â²UTR; 3â²-untranslated regio
Protein kinase C-activating tumor promoters modulate the DNA damage response in UVC-irradiated TK6 cells
Keywords: TPA; DNA damage response; Tumor promotion; p53;
Pharmacological potential and conservation prospect of the genus Eucomis (Hyacinthaceae) endemic to southern Africa
Keywords: 2,4-D; 2,4-Dichlorophenoxy acetic acid; 2-iP; N6-Isopentenyladenine; ABA; abscisic acid; BA; benzyladenine; COX; cyclooxygenase; DCM; dichloromethane; GA3; gibberellic acid; GA4+7; GA4 and GA7 gibberellin mixture; IAA; indole acetic acid; IBA; indole buty
Molecular basis of the binding of YAP transcriptional regulator to the ErbB4 receptor tyrosine kinase
Keywords: WW-ligand thermodynamics; PPXY motifs; Structural analysis; Conformational dynamics; ErbB4; erythroblastic (Erb) leukemia viral oncogene homolog B4; ITC; isothermal titration calorimetry; ITCH; ubiquitin ligase itchy homolog; LIC; ligation-independent clo
The ERK/eIF4F/Bcl-XL pathway mediates SGP-2 induced osteosarcoma cells apoptosis in vitro and in vivo
Keywords: eIF4F; eukaryotic initiation factor 4F; OS; osteosarcoma; 4E-BP1; 4E-binding protein1; ERK; extracellular-signal-regulated kinase; Bcl-XL; B-cell lymphoma-extra large; 5-FU; 5-fluorouracil; DMSO; Dimethyl sulfoxide; TPA; 12-O-tetradecanoylphorbol-13-aceta
Deoxynivalenol induced mouse skin cell proliferation and inflammation via MAPK pathway
Keywords: DON; deoxynivalenol; DMBA; 7,12-dimethylbenz[α]anthracene; MAPK; mitogen-activated protein kinase; NF-κB; nuclear factor-kappaB; TPA; 12-O-tetradecanoyl phorbol-13-acetate; ODC; ornithine decarboxylase; MPO; myeloperoxidase; Mycotoxins; Deoxynivalenol;
Targeting Nrf2-Keap1 signaling for chemoprevention of skin carcinogenesis with bioactive phytochemicals
Keywords: 4-HNE; 4-hydroxynonenal; 8OH-dG; 8-hydroxy-2â²deoxyguanosine; AMPK; cyclic-AMP-activated protein kinase; ARE; antioxidant response element; ATF; activating transcription factor; B[a]P; Benzo[a]pyrene; Bach1; broad-complex, tramtrack and bric a brac; CBP;
Secretory Hyperresponsiveness and Pulmonary Mucus Hypersecretion
Keywords: BAC; bronchoalveolar carcinoma; BHR; bronchial hyperresponsiveness; CDA; cough-dominant asthma; CF; cystic fibrosis; EGFR; epidermal growth factor receptor; ERK; extracellular-regulated kinase; LPS; lipopolysaccharide; MEC; mucoepidermoid carcinoma; MLS;
Protease Nexin-1 affects the migration and invasion of C6 glioma cells through the regulation of urokinase Plasminogen Activator and Matrix Metalloproteinase-9/2
Keywords: PN-1; Protease Nexin-1; MMP-9 and MMP-2; Matrix Metalloproteinase-9 and -2; uPA; urokinase Plasminogen Activator; shRNA; short hairpin RNA; ECM; extracellular matrix; tPA; tissue plasminogen activator; LRP; low-density lipoprotein receptor-related protein
Decorin blocks scarring and cystic cavitation in acute and induces scar dissolution in chronic spinal cord wounds
Keywords: Spinal cord injury; Decorin; ECM; Scarring; MMP; TIMP; tPA;
Functional characterization of Anaphase Promoting Complex/Cyclosome (APC/C) E3 ubiquitin ligases in tumorigenesis
Keywords: APC/C; Anaphase Promoting Complex/Cyclosome; AOM; azoxymethane; Bub3; budding uninhibited by benzimidazole protein 3; BubR1; bub1-related protein; Cdc20; cell division cycle 20; Cdh1; Cdc20 homologue protein 1; DMBA; 7,12-dimethylbenz-α-anthracene; Emi1;
Role of the ubiquitin-proteasome system in brain ischemia: Friend or foe?
Keywords: 3-MA; 3-methyladenine; 15d-PHJ2; 15-deoxy-Î12,14-prostaglandin J2; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazole proprionic acid; AMPAR; AMPA receptors; APC/C; anaphase-promoting complex/cyclosome; APV; D-aminophosphonovalerate; ATF4; activating transcri
Regulation of chondrogenesis by protein kinase C: Emerging new roles in calcium signalling
Keywords: ADAMTS; a disintegrin and metalloproteinase with thrombospondin motifs; ADSC; adipose-derived stem cell; ATP; adenosine triphosphate; BMP; bone morphogenic protein; cAMP; cyclic adenosine monophosphate; COMP; cartilage oligomeric matrix protein; CREB; cAM
The neuroprotective properties of the superoxide dismutase mimetic tempol correlate with its ability to reduce pathological glutamate release in a rodent model of stroke
Keywords: aCSF; artificial cerebrospinal fluid; BHT; butylated hydroxytoluene; Cx43; connexin 43; DCPIB; 4-[(2-butyl-6,7-dichloro-2-cyclopentyl-2,3-dihydro-1-oxo-1H-inden-5-yl)oxy]butanoic acid; DHK; dihydrokainate; DHR123; dihydrorhodamine 123; DMSO; dimethyl sulf
State-of-the-art membrane based CO2 separation using mixed matrix membranes (MMMs): An overview on current status and future directions
Keywords: 2,6-DAT; 2,6-diamino toluene; 3MPDA; 2,4,6-trimethyl-1,3-phenylenediamine; 6FDA; 2,2-bis(3,4-dicarboxyphenyl)hexafluoropropane dianhydride; 6FDA-2,6-DAT; poly(2,6-toluene-2,2-bis(3,4-dicarboxylphenyl) hexafluoropropane diimide); 6FDA-DAM; 2,2-bis(3,4-carb
Synthesis and photochemical reactivity of caged glutamates with a Ï-extended coumarin chromophore as a photolabile protecting group
Keywords: Caged; Caged glutamate; Photolysis; Bond cleavage; TPA;
Maternal familial hypercholesterolaemia (FH) confers altered haemostatic profile in offspring with and without FH
Keywords: Apo; apolipoprotein; BMI; body mass index; CV; coefficient of variation; CVD; cardiovascular disease; ELISA; enzyme-linked immunosorbant assay; F1Â +Â 2; protrombin fragment 1Â +Â 2; FH; familial hypercholesterolaemia; LDL; low density lipoprotein; PAI-1;
Epigenetic regulation of the metallothionein-1A promoter by PU.1 during differentiation of THP-1 cells
Keywords: MT; metallothionein; ChIP; chromatin immunoprecipitation; AML; acute myeloid leukemia; K562PU.1KD; PU.1-knockdown K562; K562PU.1OE; PU.1-overexpressing K562; HDAC; histone deacetylase; Dnmt; DNA methyltransferase; TPA; 12-O-tetradecanoylphorbol-13-acetate
Effects of normobaric oxygen on the progression of focal cerebral ischemia in rats
Keywords: NBO; normobaric oxygen; ICH; intracerebral hemorrhage; MCAO; middle cerebral artery occlusion; LDF; laser doppler flowmetry; PBS; phosphate-buffered saline; DAPI; 4,6-diamidino-2-phenylindole; GFAP; glial fibrillary acidic protein; tPA; tissue plasminogen
TM5275 prolongs secreted tissue plasminogen activator retention and enhances fibrinolysis on vascular endothelial cells
Keywords: tPA; tissue plasminogen activator; PAI-1; plasminogen activator inhibitor-1; VEC; vascular endothelial cell; TIRF; total internal reflection fluorescence; HBS; HEPES-buffered solution; CLSM; confocal laser scanning microscope; fibrinolysis; plasminogen ac
Visualization of cyclooxygenase-2 using a 2,3-diarylsubstituted indole-based inhibitor and confocal laser induced cryofluorescence microscopy at 20Â K in melanoma cells in vitro
Keywords: BSA; bovine serum albumin; COX-2; cyclooxygenase-2; FCS; fetal calf serum; PBS; phosphate buffered saline; TPA; tetradecanoyl phorbol acetate; Coxibs; Tumor inflammogenesis; Pigment cells; Fluorescence imaging;
Physico-chemical and functional properties of Resistant starch prepared from red kidney beans (Phaseolus vulgaris.L) starch by enzymatic method
Keywords: RS; resistant starch; SEM; scanning electron microscopy; XRD; X-ray diffractometer; TPA; texture profile analyzer; DSC; differential scanning calorimetry; WSI; water solubility index; WAC; water absorption capacity; SP; swelling power; RC; relative crysta
Proteolytic modulation of factor Xa-antithrombin complex enhances fibrinolysis in plasma
Keywords: tPA; tissue plasminogen activator; FXa; factor Xa; AT; antithrombin; Xa33/13; non-covalent heterodimer of 33Â kDa and 13Â kDa FXa fragments; Xa33/13-AT; Xa33/13 covalently linked to AT through Xa13; GEMSA; 2-guanidinoethylmercaptosuccinic acid; PEG; polye
Association for Academic SurgerySubstance P is an early mediator of peritoneal fibrinolytic pathway genes and promotes intra-abdominal adhesion formation
Keywords: Intra-abdominal adhesion; Substance P; Neurokinin-1 receptor; tPA; PAI-1; HIF-1α; HIF-2α; VEGF-A;
Activation of the antioxidant response in methionine deprived human cells results in an HSF1-independent increase in HSPA1A mRNA levels
Keywords: Heat shock factor 1; Amino acid deprivation; Methionine; DNAJB1; NRF2; GCN2; general non-derepressible 2; ATF; activating transcription factor; ASNS; asparagine synthetase; SAM; S-adenosylmethionine; HMOX1; heme oxygenase 1; GSTP; glutathione S-transferas
Quenching of the electrochemiluminescence of Ru(bpy)32+/TPA by malachite green and crystal violet
Keywords: Quenching of electrochemiluminescence; Ru(bpy)32+; TPA; Resonance energy transfer; Malachite green; Crystal violet;
A link between two tumorigenic proteins, CD44 and p21WAF1: CD44 increases phorbol ester-induced expression of p21WAF1 by stabilizing its mRNA and extending protein half-life
Keywords: p21; CD44; RNA and protein stabilization; Ras/MAPK-pathway; ERM proteins; Agar colony formation; V; empty vector; ctrl; control; ICD; intracellular domain; CHX; cycloheximide; TPA; phorbol-12-myristate 13-acetate; ERM; ezrin, radixin, moesin; MEK; mitogen
Therapeutic concentrations of valproate but not amitriptyline increase neuropeptide Y (NPY) expression in the human SH-SY5Y neuroblastoma cell line
Keywords: AMI; amitriptyline; AP-1; activator protein 1; Atoh1; atonal homolog-1; BDNF; brain-derived neurotrophic factor; bp; base pair; CREB; cAMP response element-binding protein; Cp; crossing point; ERK; extracellular signal-regulated kinase; DMEM/F12 Ham; Dulb
Comparing the performance of species distribution models of Zostera marina: Implications for conservation
Keywords: SDM; Species Distribution Models; TPA; total presence area; CPA; conservative presence area; Intertidal; Dynamics; Conservation; Seagrasses; Ecosystem Management; Wadden Sea;
Honokiol protects brain against ischemia-reperfusion injury in rats through disrupting PSD95-nNOS interaction
Keywords: NMDAR; N-methyl-d-aspartate receptor; MCAO; middle cerebral artery occlusion; OGD; oxygen-glucose deprivation; NO; nitric oxide; LDH; lactate dehydrogenase; TTC; 2,3,5-triphenyltetrazoliumchloride; DAN; 2, 3-diaminonaphthalene; DIV; days in vitro; tPA;
The influence of antigen targeting to sub-cellular compartments on the anti-allergic potential of a DNA vaccine
Keywords: Type I allergy; Immunotherapy; DNA vaccine; Ubiquitination; ER-targeting; LIMP-II; AA; amino acid; AHR; airway hyperreactivity; APC; antigen presenting cell; BAL; bronchoalveolar lavage; BALF; bronchoalveolar lavage fluid; LIMPII; 20-amino-acid C-terminal
Tissue plasminogen activator contributes to morphine tolerance and induces mechanical allodynia via astrocytic IL-1β and ERK signaling in the spinal cord of mice
Keywords: DRGs; dorsal root ganglia; ERK; extracellular signal-regulated kinase; FBS; fetal bovine serum; GAPDH; glyceraldehyde3-phosphate dehydrogenase; GFAP; glial fibrillary acidic protein; IBA-1; ionized calcium binding adapter molecule 1; IL-1β; interleukin-1
Angiotensin II stimulates cardiac fibroblast migration via the differential regulation of matrixins and RECK
Keywords: ADAM; a disintegrin and metalloproteinase domain; AP-1; activator protein-1; ARB; angiotensin receptor blockers; AT1; angiotensin II type 1 receptor; AT2; angiotensin II type II receptor; CF; cardiac fibroblasts; CMV; cytomegalovirus; CVD; cardiovascular
Classical aversive conditioning induces increased expression of mature-BDNF in the hippocampus and amygdala of pigeons
Keywords: Ani; anisomycin; ANOVA; analysis of variance; AP; anteroposterior; BDNF; brain-derived neurotrophic factor; CAU; Careful Exploration; Cond; Conditioning only; CondANI; Conditioning and Ani; CondSAL; Conditioning and saline vehicle; CS; conditioned stimulu
Mycology, cultivation, traditional uses, phytochemistry and pharmacology of Wolfiporia cocos (Schwein.) Ryvarden et Gilb.: A review
Keywords: AIF; apoptosis-inducing factor; 5-Fu; 5-fluorouracil; IC50; fifty percent inhibitory concentration; NO; nitric oxide; PLA2; phospholipase A2; PU; Polyurethane; S-180; sarcoma 180; TPA; 12-O-tetradecanoylphorbol-13-acetate; WSP; water-soluble pachyman; Wol
X-ray absorption near-edge spectroscopy in bioinorganic chemistry: Application to M-O2 systems
Keywords: XAS; X-ray absorption spectroscopy; EXAFS; extended X-ray absorption fine structure; DFT; density functional theory; NMR; nuclear magnetic resonance; XANES; X-ray absorption near-edge spectroscopy; Zeff; effective nuclear charge; LMCT; ligand to metal cha
Report de la grossesse
Keywords: Maternal age; delayed child-bearing; reproductive technology; oocyte donation; late maternal age; APT; Accouchement préterme; FPN; Faible poids de naissance; HF; Hypotrophie fÅtale; IICS; Injection intracytoplasmique d'un spermatozoïde; IIU; Inséminat
Society of Interventional Radiology Position Statement on Endovascular Acute Ischemic Stroke Interventions
Keywords: IA; intraarterial; IMS; Interventional Management of Stroke [trial]; INSTOR; Interventional Stroke Therapy Outcomes Registry; IV; intravenous; MR RESCUE; Mechanical Retrieval and Recanalization of Stroke Clots Using Embolectomy; mRS; modified Rankin scale
Experience with an evidence-based protocol using fibrinolysis as first line treatment for empyema in children
Keywords: Empyema; VATS; Fibrinolysis; Children; tPA
Chest Radiograph-based Algorithm for Managing Malfunctioning Ports
Keywords: CXR; chest x-ray; SVC; superior vena cava; tPA; tissue plasminogen activator;
Natural History of Tunneled Dialysis Catheters Placed for Hemodialysis Initiation
Keywords: CI; confidence interval; CRB; catheter-related bacteremia; ESRD; end-stage renal disease; HR; hazard ratio; LIJV; left internal jugular vein; RIJV; right internal jugular vein; TDC; tunneled dialysis catheter; tPA; tissue plasminogen activator;
Efficacy of Peripheral Interventional Radiologists Performing Endovascular Stroke Therapy Guided by CT Perfusion Triage of Patients
Keywords: ICH; intracranial hemorrhage; IMS; Interventional Management of Stroke [trial]; mRS; modified Rankin scale; NIHSS; National Institutes of Health Stroke Scale; TICI; thrombolysis in cerebral infarction; tPA; tissue plasminogen activator;