کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10956188 | 1098785 | 2014 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Differential involvement of signaling pathways in the regulation of growth hormone release by somatostatin and growth hormone-releasing hormone in orange-spotted grouper (Epinephelus coioides)
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کلمات کلیدی
U73122GHRHGH releaseGPCRGH-releasing hormonePLCdiC8PKCSSTRSGCPACAPH891,2-dioctanoyl-sn-glycerolGF109203XSRIFGHRH receptorS-nitroso-N-acetylpenicillamineGnRHPhorbol 12-myristate-13-acetateFBSPBSNOSpKacGMPtPABSA - BSAcAMP - cAMPG-protein-coupled receptor - G-پروتئین گیرندهguanosine 3′,5′-cyclic monophosphate - guanosine 3 '، 5'-cyclic monophosphateinositol phosphate - inositol فسفاتl-NAME - L-NAMEMAPK - MAPKadenosine 3′,5′-cyclic monophosphate - آدنوزین 3 '، 5'-سیکلیک منوفسفرهadenylate cyclase - آدنیلات سیکلاسbovine serum albumin - آلبومین سرم گاوDopamine - دوپامینdiacylglycerol - دیسیل گلیسیرینDAG - روزfetal bovine serum - سرم جنین گاوSomatostatin - سوماتواستاتینSoluble guanylate cyclase - سیکلاس گوانیلات حل کنندهSNAP - ضربه محکم و ناگهانیPhosphate buffered saline - فسفات بافر شورphospholipase C - فسفولیپاز CSignaling pathway - مسیر سیگنالینگNitric oxide - نیتریک اکسیدnitric oxide synthase - نیتریک اکسید سنتازGonadotropin-releasing hormone - هورمون آزاد کننده گنادوتروپینGrowth hormone - هورمون رشدprotein kinase A - پروتئین کیناز AProtein kinase C - پروتئین کیناز سیmitogen-activated protein kinase - پروتئین کیناز فعال با mitogenpituitary adenylate cyclase-activating peptide - پپتید فعال فعال آدنیلات سیکلاس هیپوفیزSomatostatin receptor - گیرنده سوماتوستاتین
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Differential involvement of signaling pathways in the regulation of growth hormone release by somatostatin and growth hormone-releasing hormone in orange-spotted grouper (Epinephelus coioides) Differential involvement of signaling pathways in the regulation of growth hormone release by somatostatin and growth hormone-releasing hormone in orange-spotted grouper (Epinephelus coioides)](/preview/png/10956188.png)
چکیده انگلیسی
Somatostatin is the most effective inhibitor of GH release, and GHRH was recently identified as one of the primary GH-releasing factors in teleosts. In this study, we analyzed the possible intracellular transduction pathways that are involved in the mechanisms induced by SRIF and GHRH to regulate GH release. Using a pharmacological approach, the blockade of the PLC/IP/PKC pathway reversed the SRIF-induced inhibition of GH release but did not affect the GHRH-induced stimulation of GH release. Furthermore, SRIF reduced the GH release induced by two PKC activators. Inhibitors of the AC/cAMP/PKA pathway reversed both the SRIF- and GHRH-induced effects on GH release. Moreover, the GH release evoked by forskolin and 8-Br-cAMP were completely abolished by SRIF. The blockade of the NOS/NO pathway attenuated the GHRH-induced GH release but had minimal effects on the inhibitory actions of SRIF. In addition, inhibitors of the sGC/cGMP pathway did not modify the SRIF- or GHRH-induced regulation of GH release. Taken together, these findings indicate that the SRIF-induced inhibition of GH release is mediated by both the PLC/IP/PKC and the AC/cAMP/PKA pathways and not by the NOS/NO/sGC/cGMP pathway. In contrast, the GHRH-induced stimulation of GH secretion is mediated by both the AC/cAMP/PKA and the NOS/NO pathways and is independent of the sGC/cGMP pathway and the PLC/IP/PKC system.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular and Cellular Endocrinology - Volume 382, Issue 2, 15 February 2014, Pages 851-859
Journal: Molecular and Cellular Endocrinology - Volume 382, Issue 2, 15 February 2014, Pages 851-859
نویسندگان
Bin Wang, Chaobin Qin, Cong Zhang, Jirong Jia, Caiyun Sun, Wensheng Li,