Fas and TRAIL ‘death receptors’ as initiators of inflammation: Implications for cancer
Keywords: قطار; Fas; TRAIL; Death receptors; Inflammation; Cancer; Cytokines
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Microvesicles in the brain: Biomarker, messenger or mediator?
Keywords: قطار; ABCA1; ATP-binding cassette transporter A1; AD; Alzheimer's disease; APP; amyloid precursor protein; Aβ; amyloid-beta peptide; CM; cerebral malaria; CNS; central nervous system; CSF; cerebrospinal fluid; EAE; experimental autoimmune encephalomyelitis; EM
The overriding of TRAIL resistance by the histone deacetylase inhibitor MS-275 involves c-myc up-regulation in cutaneous, uveal, and mucosal melanoma
Keywords: قطار; Histone deacetylase inhibitors; MS-275; TRAIL; c-myc; c-FLIP; Melanoma; Apoptosis
α-Hispanolol sensitizes hepatocellular carcinoma cells to TRAIL-induced apoptosis via death receptor up-regulation
Keywords: قطار; Hispanolone derivatives; Apoptosis; TRAIL; Death receptors; Caspase 8;
Let-7g induces granulosa cell apoptosis by targeting MAP3K1 in the porcine ovary
Keywords: قطار; Let-7g; MAP3K1; FoxO1; Granulosa cell; Apoptosis; miRNAs; mircoRNAs; 3â² UTR; 3â²-untranslated regions; GCs; granulosa cells; PTEN; phosphatase and tensin homolog; PBS; phosphate buffered saline; PI; propidium iodide; BSA; bovine serum albumin; DAPI; AT
6-Shogaol enhances renal carcinoma Caki cells to TRAIL-induced apoptosis through reactive oxygen species-mediated cytochrome c release and down-regulation of c-FLIP(L) expression
Keywords: قطار; 6-Shogaol; TRAIL; ROS; c-FLIP(L); Apoptosis;
Liposome-bound TRAIL induces superior DR5 clustering and enhanced DISC recruitment in histiocytic lymphoma U937 cells
Keywords: قطار; TRAIL; Liposome; Leukemia; Caspase; DISC; DR5;
5-Fluorouracil preferentially sensitizes mutant KRAS non-small cell lung carcinoma cells to TRAIL-induced apoptosis
Keywords: قطار; TRAIL; 5-Fluorouracil; Apoptosis; Lung cancer
A novel apoptosis-inducing mechanism of 5-aza-2â²-deoxycitidine in melanoma cells: Demethylation of TNF-α and activation of FOXO1
Keywords: قطار; αTNF-α; mAb against human TNF-alpha; Bi-seq; bisulfite sequencing; ChIP; chromatin immunoprecipitation; FasL; Fas ligand; FOXO; Forkhead box O; mAb; monoclonal antibody; MSP; methylation-specific PCR; TNF-α; tumor necrosis factor-α; TRAIL; TNF-related
Triazine-modified dendrimer for efficient TRAIL gene therapy in osteosarcoma
Keywords: قطار; Osteosarcoma; TRAIL; Dendrimer; Gene therapy
Silencing Daxx increases the anti-tumor activity of a TRAIL/shRNA Bcl-xL-expressing oncolytic adenovirus through enhanced viral replication and cellular arrest
Keywords: قطار; TRAIL; tumor necrosis factor-related apoptosis-inducing ligand; Daxx; death domain-associated protein; STAT; signal transducer and activator of transcription; PI; propidium iodide; FACS; fluorescence-activated cell sorter; MTS; 3-(4,5-dimethylthiazol-2-yl
Targeted radiotherapy potentiates the cytotoxicity of a novel anti-human DR5 monoclonal antibody and the adenovirus encoding soluble TRAIL in prostate cancer
Keywords: قطار; TRAIL; Prostate cancer; Fluorescence-activated cell sorter; Plating efficiency; Apoptosis
Delivery of tumor-homing TRAIL sensitizer with long-acting TRAIL as a therapy for TRAIL-resistant tumors
Keywords: قطار; Apoptosis; Death receptors; Nanomedicine; TRAIL; TRAIL sensitizers;
Expression of the multidrug transporter P-glycoprotein is inversely related to that of apoptosis-associated endogenous TRAIL
Keywords: قطار; ABCB1; MDR1; TRAIL; apoptosis; TET-Off; multidrug resistance; TNFSF10
Ratio of phosphorylated HSP27 to nonphosphorylated HSP27 biphasically acts as a determinant of cellular fate in gemcitabine-resistant pancreatic cancer cells
Keywords: قطار; Phosphorylated HSP27; Nonphosphorylated HSP27; Gemcitabine; Pancreatic cancer; TRAIL; tumor necrosis factor-related apoptosis-inducing ligand; DR5; death receptor 5; EGFP; enhanced green fluorescence protein; XIAP; X-linked inhibitor of apoptosis; MAPK; m
ReviewAutophagy and senescence in fibrosing cholangiopathies
Keywords: قطار; BA; biliary atresia; EMT; epithelial-mesenchymal transition; PAMP; pathogen-associated molecular patterns; PBC; primary biliary cirrhosis; PSC; primary sclerosing cholangitis; SASP; senescence-associated secretory phenotype; TLR; Toll-like receptor; TRAIL
Restoration of TRAIL-induced apoptosis in resistant human pancreatic cancer cells by a novel FAK inhibitor, PH11
Keywords: قطار; Pancreatic cancer cell lines; TRAIL; FAK inhibitor; c-FLIP; PI3K/AKT pathway
Research ArticleRepression of microRNA-130b by thyroid hormone enhances cell motility
Keywords: قطار; T3; thyroid hormone; TRs; thyroid hormone receptor; HCC; hepatocellular carcinoma; nTRE; negative thyroid hormone response element; ChIP; chromatin immunoprecipitation; PAI-1; plasminogen activator inhibitor-1; TRAIL; tumor necrosis factor (TNF)-related a
Epothilone B induces human ovarian cancer OV-90 cell apoptosis via external pathway
Keywords: قطار; EpoB; Epothilone B; PTX; paclitaxel; PARP; poly(ADP-ribose) polymerase; P-gp; glycoprotein P; TRAIL; TNF-related apoptosis-inducing ligand; TUNEL; TdT-mediated dUTP Nick-End Labeling assay; Apoptosis; Epothilone B; Paclitaxel; PARP; TUNEL; TRAIL;
Cytokines in atherosclerosis: Key players in all stages of disease and promising therapeutic targets
Keywords: قطار; Atherosclerosis; Cytokines; Chemokines; Inflammation; Therapeutic avenues; ABC; ATP-binding cassette; ACAT-1; acyl-CoA acyl transferase-1; ADRP; adipocyte differentiation related protein; Apo; apolipoprotein; BMT; bone marrow transplantation; CANTOS; Cana
Successful Interferon-Free Therapy of Chronic Hepatitis C Virus Infection Normalizes Natural Killer Cell Function
Keywords: قطار; Immune Regulation; NS5A Inhibitor; NS3 Inhibitor; ISG; APC; allophycocyanin; ASV; asunaprevir; CXCL; chemokine C-X-C motif ligand; DAA; direct-acting antiviral; DCV; daclatasvir; EMA; ethidium monoazide; EOT; end of treatment; FBS; fetal bovine serum; FIT
TRAIL-based tumor sensitizing galactoxyloglucan, a novel entity for targeting apoptotic machinery
Keywords: قطار; TRAIL; Tamarindus indica; Polysaccharide; Apoptosis; Microarray
Oncolytic vaccinia virus synergizes with irinotecan in colorectal cancer
Keywords: قطار; Double-deleted vaccinia virus; Oncolytic virotherapy; Metastatic colorectal cancer; Chemotherapy; Orthotopic tumour model; Combination therapy; CRC; colorectal cancer; MOA; mechanism of action; OV; oncolytic virus; VV; vaccinia virus; OX; oxaliplatin; CPT
Therapeutic applications of TRAIL receptor agonists in cancer and beyond
Keywords: قطار; TRAIL; Apoptosis; Cell death; Immune therapy; Cancer;
Targeting strategies on miRNA-21 and PDCD4 for glioblastoma
Keywords: قطار; GBM; glioblastoma multiforme; miRNAs; microRNAs; PDCD4; programmed cell death 4; EMT; epithelial-mesenchymal transition; JNK; Jun N-terminal protein kinase; PTEN; phosphatase and tensin homolog; PI3K/AKT; phosphatidylinositol-3 kinase/Akt; MAPK/ERK; mit
Identification of a novel synergistic induction of cell death by Smac mimetic and HDAC inhibitors in acute myeloid leukemia cells
Keywords: قطار; Apoptosis; Smac; Leukemia; Necroptosis; AML; acute myeloid leukemia; CI; combination index; cIAP; cellular inhibitor of apoptosis protein; FACS; fluorescence-activated cell-sorting analysis; FCS; fetal calf serum; FLT3; Fms-like tyrosine kinase 3; FSC/SSC
Facile one-pot formulation of TRAIL-embedded paclitaxel-bound albumin nanoparticles for the treatment of pancreatic cancer
Keywords: قطار; Albumin; Nanoparticles; TRAIL; Paclitaxel; Pancreatic cancer; Anti-cancer agent;
Regulation of cell fate by lymphotoxin (LT) receptor signalling: Functional differences and similarities of the LT system to other TNF superfamily (TNFSF) members
Keywords: قطار; Lymphotoxin; CD40; Apoptosis; Receptor cross-linking; Cell signalling; AP-1; activator protein-1; APRIL; a proliferation-inducing ligand; BAFF; B-cell activating factor belonging to the TNF family; CLL; chronic lymphocytic leukaemia; DD; death domain; DR;
HSP90 inhibitor NVP-AUY922 enhances TRAIL-induced apoptosis by suppressing the JAK2-STAT3-Mcl-1 signal transduction pathway in colorectal cancer cells
Keywords: قطار; PARP-1; poly (ADP-ribose) polymerase-1; PBS; phosphate-buffered saline solution; PI; propidium iodide; RPMI; Roswell Park Memorial Institute medium; SDS; sodium dodecyl sulfate; PAGE; polyacrylamide gel electrophoresis; TNF; tumor necrosis factor; TRAIL;
The genus Sida L. - A traditional medicine: Its ethnopharmacological, phytochemical and pharmacological data for commercial exploitation in herbal drugs industry
Keywords: قطار; ABTS; 2,2â²-azinobis-3-ethylbenzothiazoline-6-sulfonic acid; AGS; human gastric adenocarcinoma; AIU; aspirin induced ulcer; ALP; alkaline phosphatase; ALT; serum alanine aminotransferase; AP; aerial part; APPLIU; aspirin plus pylorus ligation induced ulc
Down-regulation of Fas-mediated apoptosis by plasma transglutaminase factor XIII that catalyzes fetal-specific cross-link of the Fas molecule
Keywords: قطار; BAPTA-AM; 1,2-bis(2-aminophenoxy)ethane-N,N,Nâ²,Nâ²-tetraacetic acid acetoxymethyl ester; FasL; Fas ligand; FCS; fetal calf serum; KLH; keyhole lympet hemocyanin; mAb; monoclonal antibody; MDC; monodansylcadaverine; SAF; serum anti-apoptosis factor; TCA
Additive enhancement of apoptosis by TRAIL and fenretinide in metastatic breast cancer cells in vitro
Keywords: قطار; TRAIL; Breast cancer; Cytotoxicity; Fenretinide; Chemotherapy4-HPR, Fenretinide; ROS, Reactive oxygen species; TRAIL, Tumor necrosis factor-related apoptosis-inducing ligand; ATP, Adenosine-5′-triphosphate; PARP, Poly (ADP-ribose) polymerase; FADD, Fas as
A chimeric antigen receptor for TRAIL-receptor 1 induces apoptosis in various types of tumor cells
Keywords: قطار; TRAIL; CAR; NK cell; CTL;
ALS2CR7 (CDK15) attenuates TRAIL induced apoptosis by inducing phosphorylation of survivin Thr34
Keywords: قطار; ALS2CR7 kinase; TRAIL; Survivin; Apoptosis;
Neobavaisoflavone sensitizes apoptosis via the inhibition of metastasis in TRAIL-resistant human glioma U373MG cells
Keywords: قطار; Neobavaisoflavone; Apoptosis; Glioma; Metastasis; Anoikis; TRAIL
Effets d'une compression élastique portée au cours et au décours du Trail des Forts de Besançon
Keywords: قطار; Algomètre de pression; Compression élastique; Course à pied; Effort; Récupération; Tensions musculaires; Trail; Algometer pressure; Elastic compression; Running; Stress; Recovery; Muscle tension; Trail;
Luteolin sensitizes human 786-O renal cell carcinoma cells to TRAIL-induced apoptosis
Keywords: قطار; FLIP; Luteolin; Renal cell carcinoma; TRAIL
Class I-specific histone deacetylase inhibitor MS-275 overrides TRAIL-resistance in melanoma cells by downregulating c-FLIP
Keywords: قطار; HDACis; Apoptosis; TRAIL; c-FLIP; Cutaneous melanoma; Uveal melanoma;
Ilimaquinone induces death receptor expression and sensitizes human colon cancer cells to TRAIL-induced apoptosis through activation of ROS-ERK/p38 MAPK-CHOP signaling pathways
Keywords: قطار; CHOP; CCAAT/enhancer-binding protein homologous protein; DR4, -5; death receptor 4, -5; ERK; extracellular signal-regulated kinase; p38 MAPK; p38 mitogen-activated protein kinase; JNK; c-Jun N-terminal kinase; PARP; poly-ADPribose polymerase; ROS; reactiv
HSP27 phosphorylation modulates TRAIL-induced activation of Src-Akt/ERK signaling through interaction with β-arrestin2
Keywords: قطار; HSP27; β-Arrestin; Src; TRAIL; Akt; ERK;
BH3-mimetic drugs prevent tumour onset in an orthotopic mouse model of hepatoblastoma
Keywords: قطار; HB; hepatoblastoma; SR; standard risk; HR; high risk; MDR; multi drug resistance; CDDP; cisplatin; BH3; Bcl-2 homology domain; High-risk hepatoblastoma; BH3-mimetic drugs; Tumour cell migration; Orthotopic HB model; TRAIL; TNF-α; ABT-737; Obatoclax; Paed
Suppression of orthotopically implanted hepatocarcinoma in mice by umbilical cord-derived mesenchymal stem cells with sTRAIL gene expression driven by AFP promoter
Keywords: قطار; Mesenchymal stem cell; TRAIL; Alpha-fetoprotein; Targeted therapy; Hepatocarcinoma;
Four-arm PEG cross-linked hyaluronic acid hydrogels containing PEGylated apoptotic TRAIL protein for treating pancreatic cancer
Keywords: قطار; Hydrogels; Hyaluronic acid; Four-arm PEG; TRAIL; Pancreatic cancer;
Hepatocyte expression of TRAIL pathway regulators correlates with histopathological and clinical parameters in chronic HCV infection
Keywords: قطار; cFLIP; cellular FLICE/caspase-8-inhibitory protein; cEVR; complete early viral response; CMV; cytomegalovirus; DR; death receptor; EBV; Epstein-Barr virus; EVR; early virologic response; FADD; FAS-associated via death domain; HCC; hepatocellular carcino
Reduction of death receptor 5 expression and apoptosis of CD4Â + T cells from HIV controllers
Keywords: قطار; (HIC); HIV-1 infected controllers; (IFN-α); interferon alpha; (pDC); plasmacytoid dendritic cell; (TRAIL); TNF-related Apoptosis-Inducing Ligand; (DR5); Death Receptor 5; HIV infected controllers; DR5; TRAIL; Apoptosis; CD4 + T cell;
Phosphoprotein enriched in astrocytes (PEA)-15: A potential therapeutic target in multiple disease states
Keywords: قطار; PEA-15; ERK1/2; Proliferation; Apoptosis; Cancer; Type 2 diabetes; CaMKII; calcium/calmodulin-dependent protein kinase II; DED; death effector domain; DISC; death initiation signalling complex; ERK1/2; extracellular signal-regulated kinases 1/2; FADD; Fas
Platinum(IV) complex LA-12 exerts higher ability than cisplatin to enhance TRAIL-induced cancer cell apoptosis via stimulation of mitochondrial pathway
Keywords: قطار; TRAIL; LA-12; Cisplatin; Apoptosis; Colon cancer;
Two death-inducing human TRAIL receptors to target in cancer: Similar or distinct regulation and function?
Keywords: قطار; TRAIL; DR4; DR5; Receptor preference; Apoptosis
sTRAIL coupled to liposomes improves its pharmacokinetic profile and overcomes neuroblastoma tumour resistance in combination with Bortezomib
Keywords: قطار; TRAIL; Liposomes; Neuroblastoma; Bortezomib; Combination therapies
The intricate interplay between RNA viruses and NF-κB
Keywords: قطار; ss; single-stranded; ds; double-stranded; HTLV; human T cell leukemia virus; SARS; severe acute respiratory syndrome; IAVs; influenza A viruses; IFN; interferon; IRF3; interferon regulatory factor 3; NF-κB; nuclear factor κB; TLRs; toll-like receptors;