کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10930039 | 1093373 | 2015 | 45 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Regulation of cell fate by lymphotoxin (LT) receptor signalling: Functional differences and similarities of the LT system to other TNF superfamily (TNFSF) members
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کلمات کلیدی
TNFTRAIL-RTNFRCLLDCRDIFTRAIL receptorCD40TRAFAP-1IFN-γNGFTL1AFASTNFSFJnkTNFαNF-κBc-Jun N-terminal kinase - C-Jun N-terminal kinaseHVEM - WHOAPRIL - آوریلinterferon-gamma - اینترفرون گاماBAFF - بافtumour necrosis factor-alpha - تومور نکروز عامل آلفاdeath domain - حوزه مرگTNF superfamily - خانواده TNFApoptosis - خزان یاختهایRank - رتبهCell signalling - سیگنالینگ سلولTranscription factor - عامل رونویسیtumour necrosis factor - عامل نکروز تومورDifferentiation-inducing factor - فاکتور القا کننده تمایزnerve growth factor - فاکتور رشد عصبTNFR-associated factor - فاکتور مرتبط با TNFRnuclear factor kappa B - فاکتور هسته ای کاپا BTRAIL - قطارLymphotoxin - لنفو توکسینChronic lymphocytic leukaemia - لوسمی لنفوسیتی مزمنTNF-related apoptosis-inducing ligand - لیگاند ناشی از آپوپتوز مرتبط با TNFlight - نور activator protein-1 - پروتئین فعال کننده-1TNF receptor - گیرنده TNFDecoy receptor - گیرنده طعمهdeath receptor - گیرنده مرگa proliferation-inducing ligand - یک لیگاند القا کننده تکثیر
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The role of TNFR family members in regulating cell fate both in the immune system and in non-lymphoid tissues has been under extensive research for decades. Moreover, the ability of several family members (death receptors) to induce death (mainly via apoptosis) represents a promising target for cancer therapy. Many studies have focused mostly on death receptors such as TNFRI, Fas and TRAIL-R due to their strong pro-apoptotic potential. Yet, cell death can be triggered via non-classical death receptors, and the lymphotoxin (LT) system represents a very good example of such a TNFR subfamily. Here we provide a comprehensive review of intracellular signalling pathways and cellular responses to LT-specific signalling, and compare for the first time the LT system to other TNFRs, such as CD40. Our aim is to highlight that non-classical TNFR-TNFL dyads such as the LT system demonstrate more complex, cell-type and context-specific capabilities. Understanding these complexities will permit a better understanding of the biological mechanisms via which non-death domain-containing TNFRs induce cell death, but may also allow the design of better therapeutic strategies.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cytokine & Growth Factor Reviews - Volume 26, Issue 6, December 2015, Pages 659-671
Journal: Cytokine & Growth Factor Reviews - Volume 26, Issue 6, December 2015, Pages 659-671
نویسندگان
Balid Albarbar, Christopher Dunnill, Nikolaos T. Georgopoulos,