Investigation of TRPV1 loss-of-function phenotypes in TRPV1 Leu206Stop mice generated by N-ethyl-N-nitrosourea mutagenesis
Keywords: TRPV1; Gene disruption in mice; Pain;
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TRPV1 alterations in urinary bladder dysfunction in a rat model of STZ-induced diabetes
Keywords: TRPV1; Diabetic bladder dysfunction; Patch clamp; Retrograde labeling; Tensiometry; PCR;
TRPV1 mediates the anticonvulsant effects of acetaminophen in mice
Keywords: AM404; N-(4-hydroxyphenyl-5Z,8Z,11Z,14Z-eicosatetraenamide); GABA; γ-aminobutyric acid; PG; prostaglandin; TRPV1; transient receptor potential vanilloid-1; TRPA1; transient receptor potential ankyrin 1; Acetaminophen; Anticonvulsant effect; Epileptogenes
The role of the GLP-1/GLP-1R signaling pathway in regulating seizure susceptibility in rats
Keywords: Febrile seizures (FS); GLP-1R; Hyperthermia; TRPV1;
Method to determine the impact of substantivity on ex vivo skin-permeation
Keywords: API; active pharmaceutical ingredient; HNC; Hydrophilic Nonivamide Cream; NVA; nonivamide; PBE; phosphate buffered saline pH 7.4 and ethanol in equal parts; TRPV1; transient receptor vanilloid type 1 ion channel; Substantivity; Dermal drug delivery; Noniv
Epigallocatechin-3-gallate attenuates acute and chronic psoriatic itch in mice: Involvement of antioxidant, anti-inflammatory effects and suppression of ERK and Akt signaling pathways
Keywords: Oxidative stress; EGCG; Itch; TRPV1; AKT;
Factors affecting the uncaging efficiency of 500â¯nm light-activatable BODIPY caging group
Keywords: Caged compound; BODIPY; Photo-induced electron transfer (PeT); TRPV1;
Activation of the capsaicin-receptor TRPV1 by the acetaminophen metabolite N-arachidonoylaminophenol results in cytotoxicity
Keywords: Acetaminophen; NAPQI; Analgesia; AM404; TRPV1; Neurotoxicity;
The transient receptor potential cation channel subfamily V members 1 and 2, P2X purinoceptor 3 and calcitonin gene-related peptide in sensory neurons of the rat trigeminal ganglion, innervating the periosteum, masseter muscle and facial skin
Keywords: Periosteum; Trigeminal ganglion; TRPV1; TRPV2; P2X3; Immunohistochemistry;
Impact of capsaicin, an active component of chili pepper, on pathogenic chlamydial growth (Chlamydia trachomatis and Chlamydia pneumoniae) in immortal human epithelial HeLa cells
Keywords: Chlamydia trachomatis; Capsaicin; HeLa cells; TRPV1; PPARγ; LXRα;
Antinociceptive activity of ethanolic extract of Azadirachta indica A. Juss (Neem, Meliaceae) fruit through opioid, glutamatergic and acid-sensitive ion pathways in adult zebrafish (Danio rerio)
Keywords: EtFrNeem; A. indica fruit ethanolic extract; FT-IR; fourier transform infrared spectroscopy; NMDA; N-methyl-D-aspartate (glutamatergic receptor); ASICs; acid-sensing ion channels; eROS; extracellular reactive oxygen species; 3Rs; ethical principle: reduce
TRPV1-dependent ERK1/2 activation in porcine lens epithelium
Keywords: Lens epithelium; TRPV1; ERK1/2; P38 MAPK;
Long Non-coding RNA BC168687 is Involved in TRPV1-mediated Diabetic Neuropathic Pain in Rats
Keywords: DNP; diabetic neuropathic pain; DRG; dorsal root ganglia; FPG; fasting plasma glucose; lncRNAs; long noncoding RNAs; MAPK; mitogen-activated protein kinase; MWT; mechanical withdrawal thresholds; PBS; phosphate buffer saline; PNS; peripheral nervous syste
Differential effects of lipopolysaccharide on mouse sensory TRP channels
Keywords: Endotoxin; LPS; TRPA1; TRPV1; TRPM3; TRPM8; Sensory neuron;
Anandamide inhibits FcεRI-dependent degranulation and cytokine synthesis in mast cells through CB2 and GPR55 receptor activation. Possible involvement of CB2-GPR55 heteromers
Keywords: AEA; anandamide; BMMCs; bone marrow-derived mast cells; FcεRI; high affinity IgE receptor; 2-AG; 2-arachidonoylglycerol; DNP-HSA; dinitrophenol coupled to human serum albumin (antigen); IgE; immunoglobulin E; TNF; Tumor Necrosis Factor; IL; interleukin;
Cannabinoids induce apathetic and impulsive patterns of choice through CB1 receptors and TRPV1 channels
Keywords: Decision making; Vanilloid; Cannabinoid; CB1; TRPV1; Anterior cingulate cortex; Orbitofrontal cortex;
Selective killing of proinflammatory synovial fibroblasts via activation of transient receptor potential ankyrin (TRPA1)
Keywords: RA; rheumatoid arthritis; WIN; WIN55212-2 mesylate ((R)-(+)-[2,3-Dihydro-5-methyl-3-(4-morpholinylmethyl)pyrrolo[1,2,3-de]-1,4-benzoxazin-6-yl]-1-naphthalenylmethanone mesylate); TNF; tumor necrosis factor; IL-6; interleukin-6; IL-8; interleukin-8; TRPV1;
Genetic ablation of TRPV1 exacerbates pressure overload-induced cardiac hypertrophy
Keywords: TRPV1; Heart; Hypertrophy; Inflammation; Macrophage;
A novel, topical, nonsteroidal, TRPV1 antagonist, PAC-14028 cream improves skin barrier function and exerts anti-inflammatory action through modulating epidermal differentiation markers and suppressing Th2 cytokines in atopic dermatitis
Keywords: Atopic dermatitis; TRPV1; Skin barrier function; Anti-inflammation;
Parameter-specific analgesic effects of electroacupuncture mediated by degree of regulation TRPV1 and P2X3 in inflammatory pain in rats
Keywords: Electroacupuncture; Inflammatory pain; Frequency-specific; P2X3; TRPV1;
Emerging therapies for atopic dermatitis: TRPV1 antagonists
Keywords: atopic dermatitis; clinical trials; pruritus; skin barrier; transient receptor potential; TRPV1/substance P inhibitors; AD; atopic dermatitis; NK-1R; neurokinin-1 receptor; SP; substance P; TrkA; tropomyosin receptor kinase A; TRP; transient receptor pote
Bortezomib and endocannabinoid/endovanilloid system: a synergism in osteosarcoma
Keywords: Endocannabinoid/Endovanilloid system; Osteosarcoma; Bortezomib; CB2; TRPV1;
Is heterotopic ossification getting nervous?: The role of the peripheral nervous system in heterotopic ossification
Keywords: HO; heterotopic ossification; BMP; bone morphogenetic protein; BNB; blood-nerve barrier; TRPV1; transient receptor potential cation channel subfamily V member 1; sP; substance P; CGRP; Calcitonin gene-related protein; DRG; dorsal root ganglion; BBB; blood
GABAA receptor activity modulating piperine analogs: In vitro metabolic stability, metabolite identification, CYP450 reaction phenotyping, and protein binding
Keywords: au; arbitrary units; BBB; blood brain barrier; CNS; central nervous system; CYP450; cytochrome P450; DMSO; dimethyl sulfoxide; ESI; electrospray ionization; GABAA; γ- aminobutyric acid type A receptor; HPLC; high performance liquid chromatography; HR; hi
Roles of TRPV1 and TRPA1 in Spontaneous Pain from Inflamed Masseter Muscle
Keywords: AUs; facial action units; CPP; conditioned place preference; H2O2; hydrogen peroxide; HODE; 13(S)-hydroxyoctadecadienoic acid; KO; knockout; MGS; mouse grimace scale; OLAMs; Oxidized linoleic acid metabolites; TRPA1; transient receptor potential ankyrin 1
A SNAP-25 cleaving chimera of botulinum neurotoxin /A and /E prevents TNF뱉induced elevation of the activities of native TRP channels on early postnatal rat dorsal root ganglion neurons
Keywords: Botulinum neurotoxin; TNFα; TRPV1; TRPA1; SNAP-25;
CXCL1 activates TRPV1 via Gi/o protein and actin filaments
Keywords: CXCL1; TRPV1; Dorsal root ganglia; Actin filaments; Gi/o protein;
TRPV1 modulates morphine self-administration via activation of the CaMKII-CREB pathway in the nucleus accumbens
Keywords: Morphine addiction; Self-administration; TRPV1; Nucleus accumbens;
TRPA1 Acts in a Protective Manner in Imiquimod-Induced Psoriasiform Dermatitis in Mice
Keywords: IMQ; imiquimod; KO; knockout; RTX; resiniferatoxin; TNF-α; tumor necrosis factor-α; TLR; toll-like receptor; TRPA1; transient receptor potential ankyrin 1; TRPV1; transient receptor potential vanilloid 1; WT; wild type;
TRPV1 mediates capsaicin-stimulated metabolic activity but not cell death or inhibition of interleukin-1β release in human THP-1 monocytes
Keywords: TRPV1; Capsaicin; Cytokines; Immunomodulation; Monocytes;
The oxidized linoleic acid metabolite 12,13-DiHOME mediates thermal hyperalgesia during inflammatory pain
Keywords: Oxidized linoleic acid metabolites (OLAMs); TRPV1; Thermal hyperalgesia; Inflammatory pain; sEH-inhibitor; TPPU;
Stimulation of TRPV1 channels activates the AP-1 transcription factor
Keywords: Capsaicin; Calcium; c-Fos; c-Jun; ERK; TRPV1; PD98059, PubChem CID: 4713; Capsaicin, PubChem CID: 24896598; Resiniferatoxin, PubChem CID: 5702546; N-arachidonoyldopamine, PubChem CID: 5282105;
Downregulated TRPV1 Expression Contributes to Melanoma Growth via the Calcineurin-ATF3-p53 Pathway
Keywords: qRT-PCR; quantitative real-time PCR; TRPV1; transient receptor potential vanilloid type 1;
The expression of TRPV channels, prostaglandin E2 and pro-inflammatory cytokines during behavioural fever in fish
Keywords: IPNV; Infectious Pancreatic Necrosis Virus; IL-1β; interleukin-1; IL-6; interleukin-6; TNF-α; tumor necrosis factor-α; COX-2; cyclooxygenase-2; PGE2; prostaglandin E2; TRPV1; transient receptor potential cation channel, subfamily V, member 1; TRPV4; tr
Role of Trpv1 and Trpv4 in surgical incision-induced tissue swelling and Fos-like immunoreactivity in the central nervous system of mice
Keywords: CeA; central amygdala; HPA; hypothalamic pituitary-adrenal; i.p.; intraperitoneal; Fos-LI; Fos-like immunoreactivity; PB; phosphate buffer; PBST; phosphate-buffered saline containing 0.3% Triton X-100; PFA; paraformaldehyde; PVN; paraventricular nucleus o
Experimental ischemia/reperfusion model impairs endocannabinoid signaling and Na+/K+ ATPase expression and activity in kidney proximal tubule cells
Keywords: 2-AG; 2-arachidonoylglycerol; AEA; anandamide; AM251; N-(piperidin-1-yl)-1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-1H-pyrazole-3-carboxamide; CB1; cannabinoid type-1 receptor; CB2; cannabinoid type-2 receptor; DGL; diacylglycerol lipase; ECS; endoc
Pain-like behaviors and local mechanisms involved in the nociception experimentally induced by Latrodectus curacaviensis spider venom
Keywords: LCV; Latrodectus curacaviensis venom; Widow spider; Pain; Nociception; TRPV1; Histamine; Inflammation;
Nrf2 inhibits oxaliplatin-induced peripheral neuropathy via protection of mitochondrial function
Keywords: AOPPs; advanced oxidation protein products; CI; cell index; DCFH-DA; 2â²,7â²-Dichlorofluorescin diacetate; DHE; dihydroethidium; DAB; 3,3â²-diaminobenzidine-tetrahydrochloride-dihydrate; DRG; dorsal root ganglion; GCLC; glutamate-cysteine ligase cataly
Periaqueductal gray glutamatergic, cannabinoid and vanilloid receptor interplay in defensive behavior and aversive memory formation
Keywords: Olfactory fear conditioning; Aversive memory formation; NMDA receptors; CB1 receptors; TRPV1 receptors; AMPA receptors; ANOVA; analysis of variance; CB1; cannabinoid receptor 1; PAG; periaqueductal gray matter; PMd; hypothalamic premammillar nucleus, dors
Extra-endothelial TRPV1 channels participate in alcohol and caffeine actions on cerebral artery diameter
Keywords: Ethanol; Caffeine; TRPV1 channel; Arterial smooth muscle; Cerebral artery; TRPV1 knockout mouse; BAL; blood alcohol level; BK; voltage-/calcium-gated potassium (channel) of large conductance; KO; knockout; MCA; middle cerebral artery; NOS; nitric oxide sy
Modality-specific peripheral antinociceptive effects of μ-opioid agonists on heat and mechanical stimuli: Contribution of sigma-1 receptors
Keywords: Sigma-1 receptors; Opioid drugs; Peripheral antinociception; Mechanical stimulus; Heat stimulus; TRPV1-Expressing neurons; DRG; dorsal root ganglion; IB4; isolectin B4; i.pl.; intraplantar; KO; knockout; NeuN; neuronal nuclei; PRE-084; ([2-(4-morpholineth
Acute inflammation sensitizes knee-innervating sensory neurons and decreases mouse digging behavior in a TRPV1-dependent manner
Keywords: Joint pain; Inflammation; TRPV1; Dorsal root ganglion neurons; Digging behavior; Sensitization;
Antagonists to TRPV1, ASICs and P2X have a potential role to prevent the triggering of regional bone metabolic disorder and pain-like behavior in tail-suspended mice
Keywords: Regional bone loss; Pain-like behavior; TRPV1; ASIC; P2X2/3; Prevention;
The histology, physiology, neurochemistry and circuitry of the substantia gelatinosa Rolandi (lamina II) in mammalian spinal cord
Keywords: [Ca2+]i; intracellular Ca2+ concentration; 5-HT; serotonin; Ach; acetylcholine; AMP; adenosine monophosphate; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; AMPAR; AMPA receptor; BDNF; brain-derived neurotrophic factor; CCK; cholecystokinin;
Ethanol potentiates heat response in the carotid artery via TRPV1
Keywords: Carotid artery; Heat; Ethanol; TRP; TRPV1; Capsaicin; Capsazepine;
[11C]BCTC: Radiosynthesis and in vivo binding to transient receptor potential vanilloid subfamily member 1 (TRPV1) receptor in the mouse trigeminal nerve
Keywords: Capsaicin; Transient receptor potential vanilloid subfamily member 1; TRPV1; Positron emission tomography; [11C]phosgene; [11C]BCTC; Trigeminal nerve;
Enhanced ability of TRPV1 channels in regulating glutamatergic transmission after repeated morphine exposure in the nucleus accumbens of rat
Keywords: TRPV1; Morphine withdrawal; EPSCs; Nucleus accumbens; Endogenous cannabinoids;
Effects of curcumin and curcumin analogues on TRP channels
Keywords: TRP channels; TRPA1; TRPM8; TRPV1; Curcumin; Curcuminoids;
Original articleEstablishment of preliminary regulatory network of TRPV1 and related cytokines
Keywords: Children bronchial asthma; TRPV1; Polymorphis; Cytokines; Preliminary regulatory network; miRNA; Molecular mechanism;