کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8841469 | 1615021 | 2018 | 37 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Role of Trpv1 and Trpv4 in surgical incision-induced tissue swelling and Fos-like immunoreactivity in the central nervous system of mice
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کلمات کلیدی
TrpTRPVs.c.4α-PDDTRPV4PFAi.p.TRPV1PBSTPVT4α-phorbol 12,13-didecanoate - 4α-phorbol 12،13-doecanoateCeA - CEAFos-LI - FOS-LICentral amygdala - آمیگدالای مرکزیFos-like immunoreactivity - ایمونوفیزیک Fos مانندphosphate buffer - بافر فسفاتIncision - تقسیمintraperitoneal - داخل صفاقیsubcutaneously - زیر جلدیcentral nervous system - سیستم عصبی مرکزیSpinal cord - طناب نخاعیphosphate-buffered saline containing 0.3% Triton X-100 - فسفات بافر حاوی 0.3٪ تریتون X-100 استPVN - مالیات بر ارزش افزودهHPA - میلی بار یا هکتوپاسکالwild-type - نوع وحشیParaventricular nucleus of the thalamus - هسته پروانه مرغان تالاموسparaventricular nucleus of the hypothalamus - هسته پروانه مرکزی هیپوتالاموسparaventricular nucleus - هسته پروژسترویکparaformaldehyde - پارافرمالدهیدtransient receptor potential vanilloid - پتانسیل ترانزیتی وینیلوئیدtransient receptor potential - پتانسیل گیرنده گذرا
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Role of Trpv1 and Trpv4 in surgical incision-induced tissue swelling and Fos-like immunoreactivity in the central nervous system of mice Role of Trpv1 and Trpv4 in surgical incision-induced tissue swelling and Fos-like immunoreactivity in the central nervous system of mice](/preview/png/8841469.png)
چکیده انگلیسی
Pain management remains a major concern regarding the treatment of postoperative patients. Transient receptor potential (TRP) channels are considered to be new therapeutic targets for pain control. We investigated whether the genes Trpv1 and Trpv4 are involved in hind paw swelling caused after surgical incision in mice or in incision-induced Fos-like immunoreactivity (Fos-LI) levels in the central nervous system. Mice were divided into four groups: wild-type (WT) control, WT incision, Trpv1 knockout (Trpv1â/â) incision, and Trpv4 knockout (Trpv4â/â) incision. Mice were anesthetized, and only those in the incision, and not control, groups received a surgical incision to their right plantar hind paw. Changes in paw diameter and in Fos-LI levels in the dorsal horn of the spinal cord, paraventricular nucleus of the hypothalamus (PVN), paraventricular nucleus of the thalamus, and central amygdala were evaluated 2â¯h after the incision. There was no significant difference in the paw diameter among groups. In contrast, in laminae I-II of the dorsal horn of the spinal cord and PVN, Fos-LI was significantly higher in all incision groups than in the WT control group. A significant increase in Fos-positive cells was also observed in the dorsal horn laminae III-IV in Trpv1â/â and Trpv4â/â incision groups compared with the WT incision group. Our results indicate that surgical incision activates the PVN and that Trpv1 and Trpv4 might be involved in neuronal activity in the dorsal horn laminae III-IV after surgical incision.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 678, 21 June 2018, Pages 76-82
Journal: Neuroscience Letters - Volume 678, 21 June 2018, Pages 76-82
نویسندگان
Yasuhito Motojima, Haruki Nishimura, Hiromichi Ueno, Satomi Sonoda, Kazuaki Nishimura, Kentaro Tanaka, Reiko Saito, Mitsuhiro Yoshimura, Takashi Maruyama, Takanori Matsuura, Hitoshi Suzuki, Makoto Kawasaki, Hideo Ohnishi, Akinori Sakai, Yoichi Ueta,