کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7279158 | 1473895 | 2018 | 37 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The expression of TRPV channels, prostaglandin E2 and pro-inflammatory cytokines during behavioural fever in fish
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کلمات کلیدی
IL-6TRPV1POABehavioural feverIPNVCOX-2PGE2transient receptor potential cation channel, subfamily V, member 1IL-1βTRPV4Aminobutyric acid - اسید آمینه اسیدEctotherm - اکوترومinterleukin-6 - اینترلوکین ۶interleukin-1 - اینترلوکین-1tumor necrosis factor-α - تومور نکروز عامل αCytokine - سیتوکینCyclooxygenase-2 - سیکلوکوکسیژناز2TNF-α - فاکتور نکروز توموری آلفاVirus - ویروسInfectious pancreatic necrosis virus - ویروس ناکروز پانکراس عفونیProstaglandin E2 - پروستاگلاندین E2TRP channels - کانال های TRPGABA - گابا
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
A fever, or increased body temperature, is a symptom of inflammation, which is a complex defence reaction of the organism to pathogenic infections. After pathogens enter the body, immune cells secrete a number of agents, the functions of which stimulate the body to develop a functional immune and fever response. In mammals it is known that PGE2 is the principal mediator of fever. The extent to which PGE2 and other pro-inflammatory cytokines such as TNF-α, IL-6, or IL-1β could be involved in the induction of behavioural fever in fish remains to be clarified. Several members of the transient receptor potential (TRP) family of ion channels have been implicated as transducers of thermal stimuli, including TRPV1 and TRPV2, which are activated by heat. Here we show that members of the TRP family, TRPV1 and TRPV4, may participate in the coordination of temperature sensing during the behavioural fever. To examine the behavioral fever mechanism in Salmo salar an infection with IPNV, infectious pancreatic necrosis virus, was carried out by an immersion challenge with 10â¯Ãâ¯105 PFU/mLâ1 of IPNV. Behavioural fever impacted upon the expression levels of both TRPV1 and TRPV4 mRNAs after the viral challenge and revealed a juxtaposed regulation of TRPV channels. Our results suggest that an increase in the mRNA abundance of TRPV1 is tightly correlated with a significant elevation in the expression of pro-inflammatory cytokines (IL-1β, IL-6, TNF-α and PGE2) in the Pre-Optic Area (POA) and cytokine release in plasma. Together, these data indicate that the reduction of TRPV4 expression during behavioural fever may contribute to the onset of behavioural fever influencing movement toward higher water temperatures. Our data also suggest an effect of TRPV channels in the regulation of behavioural fever through activation of EP3 receptors in the central nervous system by PGE2 induced by plasma-borne cytokines. These results highlight for first time in mobile ectotherms the key role of pro-inflammatory cytokines and TRPV channels in behavioural fever that likely involves a complex integration of prostaglandin induction, cytokine recognition and temperature sensing.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain, Behavior, and Immunity - Volume 71, July 2018, Pages 169-181
Journal: Brain, Behavior, and Immunity - Volume 71, July 2018, Pages 169-181
نویسندگان
Sebastian Boltana, Nataly Sanhueza, Andrea Donoso, Andrea Aguilar, Diego Crespo, Daniela Vergara, Gabriel Arriagada, Byron Morales-Lange, Luis Mercado, Sonia Rey, Lluis Tort, Simon Mackenzie,