Keywords: Saponins; Phenolic compounds; Defatted rice bran; Antioxidant activity; ABTS; 2,2â²-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid); AqF; aqueous fraction; BCB; β-carotene bleaching; BF; n-Butanol fraction; CAE; crude alcoholic extract; DPPH; 2,2-diph
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Keywords: CFB; Central fibrous body; IUD; Intrauterine death; IVS; Interventricular septum; SENs; Sub-ependymal nodules; TSC; Tuberous sclerosis complex;
Keywords: AA; amino acids; BLAST; basic alignment search tool; Ca; calcium; CaSR; calcium sensing receptor; ENaC; epithelial amiloride-sensitive sodium channel; GIT; gastrointestinal tract; GLU; glutamic acid; GLUT2; glucose transporter 2; Na; sodium; NaCl; sodium
Keywords: 4E-BP1; eIF4E binding protein 1; 5â²-UTR; 5â²-untranslated region; AMPK; AMP-activated protein kinase; eIF; eukaryotic initiation factor; GCN2; general-control nonderepressible; GEF; guanine nucleotide exchange factor; GSK-3; glycogen synthase kinase-3;
Inhibitory effect of quinoa and fenugreek extracts on pancreatic lipase and α-amylase under in vitro traditional conditions or intestinal simulated conditions
Keywords: 4-MUO; 4-methylumbelliferyl oleate; CEE; concentrated ethanol extract(s); EE; ethanol extract(s); MetS; metabolic syndrome; TFA; trifluoroacetic acid; TPC; total phenolic content; TSC; total saponin content; TIC; total content of inhibitory compounds; Orl
Methodology for tissue sample collection within a translational sub-study of the CHHiP trial (CRUK/06/016), a large randomised phase III trial in localised prostate cancer
Keywords: BATS; Blood and Tissue Samples database; BIDD; Biomarker and Imaging Discovery and Development Committee; CHHiP; Conventional or Hypofractionated High dose intensity modulated radiotherapy in Prostate cancer; CRN; Clinical Research Network; CTU; Clinical
MTOR pathway in focal cortical dysplasia type 2: What do we know?
Keywords: FCD; focal cortical dysplasia; FCD II; focal cortical dysplasia type 2; FLE; frontal lobe epilepsy; GG; ganglioglioma; HME; hemimegalencephaly; ILAE; International League Against Epilepsy; MCD; malformation of cortical development; MPPH; megalencephaly-
Burden of illness in patients with possible Lennox-Gastaut syndrome: A retrospective claims-based study
Keywords: LGS; Lennox-Gastaut syndrome; EEG; electroencephalographic; ICD; International Classification of Diseases; AED; antiepileptic drug; TSC; tuberous sclerosis complex; IP; inpatient; OP; outpatient; ED; emergency department; VNS; Vegus nerve stimulation; H
Superselective Transcatheter Arterial Embolization for Large Unruptured Renal Angiomyolipoma in Lymphangioleiomyomatosis
Keywords: AML; angiomyolipoma; GSP; gelatin sponge particle; LAM; lymphangioleiomyomatosis; TAE; transcatheter arterial embolization; TSC; tuberous sclerosis complex;
Metal- and redox homeostasis in prostate cancer with vitamin D3 supplementation
Keywords: Al; aluminium; ALT; alanine transaminase; AP-1; activated protein-1; AR; androgen receptor; AST; aspartate transaminase; B; boron; Ba; barium; BMI; body mass index; Ca; calcium; CDK4; cyclin dependent kinase; CEA; carcynoembrionic antigene; Chol; choles
Morphological, physiological and phytochemical response of different Satureja hortensis L. accessions to salinity in a greenhouse experiment
Keywords: SDW; shoot dry weight; SFW; shoot fresh weight; TPC; total phenolic compounds; TSC; total soluble carbohydrate; Chl a; chlorophyll a; Chl b; chlorophyll b; TChl; total chlorophyll; Accession; Essential oil; Phenolic compounds; Salinity; Satureja hortensis
A role for Glucagon-Like Peptide-1 in the regulation of β-cell autophagy
Keywords: Akt; protein kinase B; Ambra1; Autophagy And Beclin 1 Regulator 1; AMPK; 5â² AMP-activated protein kinase; Atg; autophagy related proteins; CAMKK; Ca2+/calmodulin-dependent protein kinase kinase; DFCP1; double FYVE-containing protein 1; DPP4; dipeptidyl
Design and synthesis of alkyl substituted pyridino[2,3-D]pyrimidine compounds as PI3Kα/mTOR dual inhibitors with improved pharmacokinetic properties and potent in vivo antitumor activity
Keywords: PI3K; phosphoinositide 3-kinase; mTOR; mammalian target of rapamycin; TSC; tuberous sclerosis; DDQ; 2,3-dicyano-5,6-dichlorobenzoquinone; THF; tetrahydrofuran; DIPEA; N,N-diisopropylethylamine; DMF; N,N-dimethylformamide; MRT; mean retention time; PI3Kα/
Preliminary results of a new MIMO plasma shape controller for EAST
Keywords: 52.55.Fa; 52.65.-y; 52.50.Nr; Multiple-input multiple-output; Plasma shape control; EAST; TSC;
Uncoupling of ER/Mitochondrial Oxidative Stress in mTORC1 Hyperactivation-Associated Skin Hypopigmentation
Keywords: ATP; adenosine triphosphate; ER; endoplasmic reticulum; p-; phosphorylated; PBA; 4-phenylbutyrate; TSC; tuberous sclerosis complex;
Numerical investigation of in-vessel core coolability of PWR through an effective safety injection flow model using MELCOR simulation
Keywords: SAMG; In-vessel coolability; Safety injection flow map; Oxidation heat; Core exit temperature; MELCOR; ADV; Atmospheric Dump Valve; AFW; Auxiliary Feed Water; BWR; Boiling Water Reactor; CDV; Condenser Dump Valve; CET; Core Exit Temperature; CV; Control V
Plk2 Loss Commonly Occurs in Colorectal Carcinomas but not Adenomas: Relationship to mTOR Signaling
Keywords: Plk2; Polo-like kinase 2; TSC; tuberous sclerosis complex; mTOR; mammalian target of rapamycin; p70S6K/S6K; S6: Ribosomal protein S6 kinase; AMPK; AMP-responsive protein kinase; REDD 1; regulated in DNA damage and development 1; 4EBP1; eukaryotic translat
Longitudinal expression patterns of HMGR, FPS, SS, SE and DS and their correlations with saponin contents in green-purple transitional aerial stems of Panax notoginseng
Keywords: ANOVA; analysis of variance; Ct; cycle threshold value; CYP450; cytochrome P450; DS; dammarenediol synthase gene; DS; dammarenediol synthase; FPS; farnesyl pyrophosphate synthase gene; FPS; farnesyl pyrophosphate synthase; GAPDH; glyceraldehyde phosphate
Identification of epsilon toxin-producing Clostridium perfringens strains in American retail food
Keywords: Clostridium perfringens; Epsilon toxin; Genotype; Toxinotype; American; Retail food; RPM; Rapid perfringens media; TSC; Tryptose sulfite cycloserine agar; ON; Overnight; USA; United States of America; MS; Multiple Sclerosis; PBS; Phosphate buffered saline
Long-Term Effect of Sirolimus on Serum Vascular Endothelial Growth Factor D Levels in Patients With Lymphangioleiomyomatosis
Keywords: lung function; lymphangioleiomyomatosis; lymphatic disease; sirolimus; VEGF-D; AML; angiomyolipoma; Dlco; diffusion capacity for carbon monoxide; LAM; lymphangioleiomyomatosis; MILES; Multicenter International Lymphangioleiomyomatosis Efficacy and Safety
Complexes of pyridoxal thiosemicarbazones formed with vanadium(IV/V) and copper(II): Solution equilibrium and structure
Keywords: TSC; thiosemicarbazone; PxTSC; pyridoxal thiosemicarbazone; PxTSCm; pyridoxal-N3,N3-dimethylthiosemicarbazone; STSC; salicylaldehyde thiosemicarbazone; SSC; salicylaldehyde semicarbazone; l-ProSTSC; 2-hydroxy-3-methyl-(S)-pyrrolidine-2-carboxylate-5-methy
Changes in gene expression following long-term in vitro exposure of Macaca mulatta trophoblast stem cells to biologically relevant levels of endocrine disruptors
Keywords: ATR; atrazine; BPA; bisphenol A; CP; canonical pathway; DEG; differentially expressed gene; DEHP; di-(2-ethylhexyl) phthalate; DF; disease and function; EDC; endocrine disrupting chemical; ESC; embryonic stem cell; TSC; trophoblast stem cell; IPA; QIAGEN
PI3K pathway in prostate cancer: All resistant roads lead to PI3K
Keywords: CRPC; castration-resistant prostate cancer; ADT; androgen deprivation therapy; PI3K; phosphoinositide 3-kinase; AR; androgen receptor; PTEN; phosphatase and tensin homologue deleted on chromosome 10; INPP4B; inositol polyphosphate 4-phosphatase type II; P
Dissection of resistance to Microdochium nivale in Lolium multiflorum/Festuca arundinacea introgression forms
Keywords: Carbohydrates; Forage grasses; Phytohormones; GISH/FISH; Phenolics; Snow mould; ABA; abscisic acid; DAPI; 4â²,6-diamidine-2â²-phenylindole dihydrochloride; DW; dry weight; Fa; Festuca arundinacea; FISH; fluorescent in situ hybrydization; H; hardening; G
Neural progenitors derived from Tuberous Sclerosis Complex patients exhibit attenuated PI3K/AKT signaling and delayed neuronal differentiation
Keywords: TSC; Tuberous Sclerosis Complex; mTOR; mammalian target of rapamycin; mTORC1; mTOR complex 1; LOH; loss of heterozygosity; iPSCs; induced pluripotent stem cells; NPCs; neural progenitor cells; PI3K; phosphoinositide 3-kinase; SENs; subependymal nodules; S
Agmatine potentiates neuroprotective effects of subthreshold concentrations of ketamine via mTOR/S6 kinase signaling pathway
Keywords: Agmatine; Akt; HT22; Ketamine; Neuroprotection; p70S6 kinase; PSD95; 4E-BPs; 4E binding proteins; ANOVA; analysis of variance; DMEM; Dulbecco's Modified Eagle Medium; ECT; electroconvulsive therapy; CUS; chronic unpredictable stress; FST; forced swim test
FLCN: The causative gene for Birt-Hogg-Dubé syndrome
Keywords: AEC; alveolar epithelial type II cell; AKT; protein kinase B; AMPK/Ampk; 5â²-AMP activated protein kinase; AMPKα (also AAK-2); AMPKα subunit; ATP; adenosine triphosphate; Bcl-2; B-cell lymphoma 2; BHD; Birt-Hogg-Dubé; BAT; brown adipose tissue; C. ele
Drosophila as a model for ageing
Keywords: 4EBP; translation initiation factor 4E binding protein; AMPK; AMP activated protein kinase; AOP; anterior open; ATF4; activating transcription factor 4; CHOP; C/EBP homologous protein; CR; calorie restriction; DR; dietary restriction; eIF; eukaryotic tran
Early dietary restriction in rats alters skeletal muscle tuberous sclerosis complex, ribosomal s6 and mitogen-activated protein kinase
Keywords: Muscle, skeletal; Rats; Diet reducing; Fetal growth retardation; TOR serine-threonine kinase; Mitogen-activated protein kinase phosphatases; 4EBP1; 4E binding protein-1; AMP; adenosine monophosphate-activated protein; CON; control; eIF4E; eukaryotic tra
The novel, catalytic mTORC1/2 inhibitor PQR620 and the PI3K/mTORC1/2 inhibitor PQR530 effectively cross the blood-brain barrier and increase seizure threshold in a mouse model of chronic epilepsy
Keywords: Epilepsy; Rapamycin; Everolimus; Pharmacokinetics; Tolerability; Levetiracetam; AKT; protein kinase B; ASD; anti-seizure drug; 4E-BP1; initiation factor 4E binding protein; HPβCD; hydroxypropyl-Ã-cyclodextrin; MTD; maximal tolerated dose; MES-T; maximal
Quantitative sodium MR imaging: A review of its evolving role in medicine
Keywords: AD; Alzheimer's disease; ATP; adenosine triphosphate; Clâ; chloride ion; CSC; cartilage sodium concentration; CSF; cerebrospinal fluid; CVF; cell volume fraction; DCE; dynamic contrast enhancement; DSC; dynamic susceptibility contrast; ECM; extracellula
The chemistry and pharmacology of Ligularia przewalskii: A review
Keywords: A375; human melanoma cells; ABTS; 2,2'-azinobis (3-ethylbenzothiazoline-6- sulfonic acid); AChE; acetylcholinesterase; AD; Alzheimer's disease; AGEs; advanced glycation endproducts; B16F10; mouse skin melanoma; BACE1; β-site amyloid precursor cleavin
Review on earth-abundant and environmentally benign Cu-Sn-X(XÂ =Â S, Se) nanoparticles by chemical synthesis for sustainable solar energy conversion
Keywords: Ab; ambient or atmosphere; tBu2Se2; di-tert-butyl diselenide; CR; conventional heating under refluxing conditions; DDA; dodecylamine; DDAB; dode-cyldimethylammonium bromide; DDT; dodecanethiol; DMF; N,N-dimethylformamide; EA; ethanolamine; EDT; 1,2-ethane
Development of ramp up design workflow on CFETR Integrated Design Platform
Keywords: Workflow of plasma ramp up; CFETR; TSC; ONETWO; ANSYS;
Development of hypomelanotic macules is associated with constitutive activated mTORC1 in tuberous sclerosis complex
Keywords: Hypomelanotic macules; mTOR; Silent substitution; TSC; TSC2;
Cosmos caudatus extract/fractions reduce smooth muscle cells migration and invasion in vitro: A potential benefit of suppressing atherosclerosis
Keywords: ABTS; 2,2â²-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid); AP-1; activator protein-1; Aq.F; aqueous fraction; BCB; β-carotene bleaching activity; Bu.F; butanol fraction; CEE; crude alcoholic extract; Cr.F; crude fraction; CVD; cardiovascular diseas
Dysregulation of autophagy in melanocytes contributes to hypopigmented macules in tuberous sclerosis complex
Keywords: Autophagy; TSC; mTOR; Rapamycin; Pigmentation;
Brain sodium MRI in human epilepsy: Disturbances of ionic homeostasis reflect the organization of pathological regions
Keywords: EZ/IZ1; Epileptogenic/Primary Irritative Zone; IED; Interictal Epileptic Discharge; IZ2; Secondary Irritative Zone;; TSC; Total Sodium Concentration;; VGSC; Voltage-Gated Sodium Channels; Sodium MRI; Epilepsy; Intracranial EEG; Cortical localisation; Epil
RIP3 antagonizes a TSC2-mediated pro-survival pathway in glioblastoma cell death
Keywords: 5-ALA; 5-aminolevulinic acid; MK2; MAP Kinase-Activated Protein kinase 2; p38; Mitogen-Activated Protein kinase p38; PDT; Photodynamic Therapy; RIP; Receptor Interacting Protein; TSC; Tuberous Sclerosis; YWHA; Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxy
Everolimus for the Treatment of Tuberous Sclerosis Complex-Related Cardiac Rhabdomyomas in Pediatric Patients
Keywords: cardiac tumors; hamartomas; mTOR inhibition; infants; cRHM; Cardiac rhabdomyoma; mTOR; Mammalian target of rapamycin; SEGA; Subependymal giant cell astrocytoma; TSC; Tuberous sclerosis complex;
DNA damage response and autophagy in the degeneration of retinal pigment epithelial cells-Implications for age-related macular degeneration (AMD)
Keywords: 9-1-1 complex; complex of Rad9 Rad1 and Hus1 proteins; A2E; N-retinylidene-N-retinylethanol-amine; AtRal; all-trans retinal; AMD; age-related macular degeneration; AMPK; AMP-activated protein kinase; Atg; autophagy-related gene; ATM; ataxia-telangiectasia
Review on the management of RCCI engines
Keywords: ATDC; after top dead center; BMEP; brake mean effective pressure; CA50; crank angle of 50% heat released; CA; crank angle; CDC; conventional diesel combustion; CI; compression ignition; CO; carbon monoxide; CRI; common rail injector; DDFS; direct dual fue
The role of the TOR pathway in mediating the link between nutrition and longevity
Keywords: TOR; target of rapamycin; TSC; tuberous sclerosis complex; Rheb; Ras homologue enriched in brain; 4EBP; 4E binding protein; S6K; S6 kinase; PI3K; phosphatidylinositol-3-kinase; Raptor; regulatory-associated protein of mTOR; Deptor; DEP domain-containing m
The roles of subcellularly located EGFR in autophagy
Keywords: AMPK; AMP-activated protein kinase; ATG; autophagy-related; BCL2; B-cell lymphoma 2; BCL2L1; BCL2 like 1; BNIP3; BCL2/Adenovirus E1B-binding protein Nip3; CME; clathrin-mediated endocytosis; cytoSTAT3; cytoplasmic STAT3; Dsbs; double strand breaks; ECD; e
Role of Akt/PKB and PFKFB isoenzymes in the control of glycolysis, cell proliferation and protein synthesis in mitogen-stimulated thymocytes
Keywords: 4E-BP1; eukaryotic initiation factor 4E-binding protein 1; AMPK; AMP-activated protein kinase; BSA; bovine serum albumin; ConA; concanavalin A; eEF2; eukaryotic elongation factor 2; eIF; eukaryotic initiation factor; ERK; extracellular-signal-regulated
Molecular neurobiology of mTOR
Keywords: 4E-BPs; 4E-binding proteins; Atg13; autophagy-related protein 13; BDNF; brain-derived neurotrophic factor; CGG; trinucleotide; EGF; epidermal growth factor; FXS; Fragile X syndrome; Hif1α; hypoxia-inducible factor 1-α; LTD; long-term depression; LTP; lo
The cochaperone BAG3 coordinates protein synthesis and autophagy under mechanical strain through spatial regulation of mTORC1
Keywords: BAG3; BCL2-associated athanogene; mTOR; mammalian target of rapamycin; mTORC1; mammalian target of rapamycin complex 1; TSC; tuberous sclerosis; CASA; chaperone-assisted selective autophagy; CMA; chaperone-mediated autophagy; RE; maximal eccentric resista
1,25-Dihydroxyvitamin-D3 prevents the development of diabetic cardiomyopathy in type 1 diabetic rats by enhancing autophagy via inhibiting the β-catenin/TCF4/GSK-3β/mTOR pathway
Keywords: 1,25D3; 1,25-dihydroxyvitamin D3; VDR; vitamin D receptor; 25(OH)D; 25-dihydroxyvitamin D; DCM; diabetic cardiomyopathy; CQ; chloroquine; STZ; streptozotocin; lenti-shVDR; lentiviral vectors expressing a short hairpin RNA against VDR; TSC; tuberous sclero
Potential of GPCRs to modulate MAPK and mTOR pathways in Alzheimer's disease
Keywords: AD; Alzheimer's disease; AGC; protein kinase A/protein kinase G/protein kinase C; Akt; protein kinase B; ATG13; autophagy-related gene 13; Aβ; amyloid-beta; BDNF; brain-derived neurotrophic factor; CaMKII; Ca2+/calmodulin-dependent kinase II; cAMP; cyc
Nipple Angiofibromas with Loss of TSC2 Are Associated with Tuberous Sclerosis Complex
Keywords: TSC; tuberous sclerosis complex;