کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8683481 | 1579807 | 2018 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
MTOR pathway in focal cortical dysplasia type 2: What do we know?
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کلمات کلیدی
HMEMolecular and cellular biologyPubMedFLEGangliogliomamTORC1SEGAMCDFCDPI3KTSCmTORSubependymal giant cell astrocytoma - آستروسیتوم سلول غول پیکر SubependymalILAE - ایلاtuberous sclerosis - توبروز اسکلروزیسTUNEL - تونلfocal cortical dysplasia - دیسپلازی قشر مرکزیFrontal Lobe Epilepsy - صرع لوب اولیهdrug-resistant epilepsy - صرع مقاوم در برابر داروMalformation of cortical development - ضعف توسعه قشرphosphoinositide 3-kinase - فسفینوزیتید 3-کینازInternational League against Epilepsy - لیگ بین المللی علیه صرعmammalian target of rapamycin - هدف پستانداران رپامایسینMammalian target of rapamycin complex 1 - هدف پستانداران مجتمع رپامایسین 1hemimegalencephaly - هما مگالنسفالیTuberous sclerosis complex - کمپلکس توبروس اسکلروزیس
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: MTOR pathway in focal cortical dysplasia type 2: What do we know? MTOR pathway in focal cortical dysplasia type 2: What do we know?](/preview/png/8683481.png)
چکیده انگلیسی
Focal cortical dysplasia (FCD) is the most commonly encountered developmental malformation that causes refractory epilepsy. Focal cortical dysplasia type 2 is one of the most usual neuropathological findings in tissues resected therapeutically from patients with drug-resistant epilepsy. Unlike other types of FCD, it is characterized by laminar disorganization and dysplastic neurons, which compromise the organization of the six histologically known layers in the cortex; the morphology and/or cell location can also be altered. A comprehensive review about the pathogenesis of this disease is important because of the necessity to update the results reported over the past years. Here, we present an updated review through Pubmed about the mammalian target of rapamycin (MTOR) pathway in FCD type 2. A wide variety of aspects was covered in 44 articles related to molecular and cellular biology, including experiments in animal and human models. The first publications appeared in 2004, but there is still a lack of studies specifically for one type of FCD. With the advancement of techniques and greater access to molecular and cellular experiments, such as induced pluripotent stem cells (iPSCs) and organoids, it is believed that the trend is increasing the number of publications contributing to the achievement of new discoveries.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Epilepsy & Behavior - Volume 85, August 2018, Pages 157-163
Journal: Epilepsy & Behavior - Volume 85, August 2018, Pages 157-163
نویسندگان
Fernanda Majolo, Daniel Rodrigo Marinowic, Denise Cantarelli Machado, Jaderson Costa Da Costa,