دانلود مقالات ISI درباره Tyk2 + ترجمه فارسی

نقش ظهور عامل کنترل کننده اینترفرون 9 در پاسخ میزبان ضد ویروسی و فراتر از آن

The emerging role of interferon regulatory factor 9 in the antiviral host response and beyond

Keywords: OASL; 2'-5'-oligoadenylate synthetase; PKR; double-stranded RNA-dependent protein kinase; GAS; gamma-activated site; HCMV; human cytomegalovirus; ISG; IFN-I-stimulated genes; IFNAR; interferon alpha receptor; IFNGR; interferon gamma receptor; IRF; interfe

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

بروز ابتلا به کمبود ایمنی

Primary immunodeficiency update

Keywords: AD; autosomal dominant; AD-HIES; autosomal dominant hyper-immunoglobulin E syndrome; AR; autosomal recessive; BMD; bone mineral density; CMC; chronic mucocutaneous candidiasis; DOCK8; dedicator of cytokinesis 8; EBV; Epstein-Barr virus; FOXP3; forkhea

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

اینترفرون های انسانی انسانی: برداشتن سیتوکین های طبیعی و مصنوعی با اختلال ذاتی

Human consensus interferons: Bridging the natural and artificial cytokines with intrinsic disorder

Keywords: cIFN; consensus interferon; EDHS; Egyptian Demographic Health Survey; FDA; Food and Drug Administration; HBV; hepatitis B virus; HCV; hepatitis C virus; IFN; interferon; IFNAR; IFN-α/β receptor; IFNGR; IFN-γ receptor; IRF9; IFN-regulatory factor 9; ISG

دانلود رایگان متن کامل مقاله ISI 35 صفحه سال انتشار : 2015 سفارش ترجمه

گیرنده های سطحی سلول های نوتروفیل و مسیرهای انتقال سیگنال داخل سلولی آنها

Neutrophil cell surface receptors and their intracellular signal transduction pathways

Keywords: Abl; Abelson leukemia proto-oncogene; ADAP; adhesion and degranulation promoting adapter protein (Fyb, SLAP-130); Asc; apoptosis-associated speck-like protein containing a CARD; BCR; B-cell receptor; C3G; Crk SH3 domain-binding guanine nucleotide exchange

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2013 سفارش ترجمه

Quercetin inhibits the poly(dA:dT)-induced secretion of IL-18 via down-regulation of the expressions of AIM2 and pro-caspase-1 by inhibiting the JAK2/STAT1 pathway in IFN-γ-primed human keratinocytes

Keywords: Quercetin; IL (interleukin)-18; AIM (absent in melanoma) 2; Inflammasome; Keratinocytes; JAK/STAT pathway; IL-18; Interleukin (IL)-18; HEKn; Human primary epidermal keratinocytes from neonatal foreskin; IFN-γ; interferon-γ; AIM2; absent in melanoma 2; A

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2018 سفارش ترجمه

IL-21 alleviates allergic asthma in DOCK8-knockout mice

Keywords: DOCK8 gene; Allergic asthma; Ovalbumin; Murine model; IL-21; rmIL-21; recombinant mouse interleukin-21; DOCK8; dedicator of cytokinesis 8; STAT3; signal transducer and activator of transcription 3; TYK2; tyrosine kinase 2; DIDS; DOCK8 immunodeficiency syn

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2018 سفارش ترجمه

Down-regulation of TYK2, CBLB and LMP7 genes expression in relapsing-remitting multiple sclerosis patients treated with interferon-beta

Keywords: Multiple sclerosis; TYK2; CBLB; LMP7; Gene; Interferon-beta;

دانلود رایگان متن کامل مقاله ISI 27 صفحه سال انتشار : 2018 سفارش ترجمه

Pre-clinical and translational pharmacology of a human interleukin-22 IgG fusion protein for potential treatment of infectious or inflammatory diseases

Keywords: AUClast; Area under concentration-time curve; CL; Total clearance; COLO205; Intestinal epithelial cells; Cmax; Maximal serum concentration; DC; Dendritic Cells; DMEM; Dulbecco's modified Eagle's medium; DSS; Dextran sulfate sodium salt; EC50; Half max

دانلود رایگان متن کامل مقاله ISI 46 صفحه سال انتشار : 2018 سفارش ترجمه

STAT3: The art of multi-tasking of metabolic and immune functions in obesity

Keywords: Signal transducer and activator of transcription 3; Obesity; Metabolism; Lipid; Immune; AgRP; Agouti-related peptide; AMPK; AMP-activated protein kinase; AOX; acyl-CoA oxidase; ARC; arcuate nucleus; ATGL; adipose triglyceride lipase; BAT; brown adipose ti

دانلود رایگان متن کامل مقاله ISI 51 صفحه سال انتشار : 2018 سفارش ترجمه

The connexin 43 C-terminus: A tail of many tales

Keywords: Akt; protein kinase B; CCN; CYR61/connective tissue growth factor/nephroblastoma overexpressed; CDK1; cyclin-dependent kinase 1; CIP75; Cx43-interacting protein of 75 kDa; CIP85; Cx43-interacting protein of 85-kDa; CK1; casein kinase 1; Csk; C-terminal c

دانلود رایگان متن کامل مقاله ISI 53 صفحه سال انتشار : 2018 سفارش ترجمه

Flaviviridae virus nonstructural proteins 5 and 5A mediate viral immune evasion and are promising targets in drug development

Keywords: AAF; IFN-α-activated factor; ATA; Aurintricarboxylic acid; BDV; border disease virus; BPgV; GBV-D; BVDV-1; bovine viral diarrhea virus-1; C; capsid protein; CLRs; C-type lectin receptors; Core; core protein; CSFV; classical swine fever virus; DENV; dengu

دانلود رایگان متن کامل مقاله ISI 60 صفحه سال انتشار : 2018 سفارش ترجمه

Molecular cloning, transcriptional profiling, and subcellular localization of signal transducer and activator of transcription 2 (STAT2) ortholog from rock bream, Oplegnathus fasciatus

Keywords: STAT2; signal transducer and activator of transcription 2; JAK; Janus kinase; IL-10; interleukin-10; TYK2; tyrosine kinase 2; IFN; interferon; ISGF3; IFN-stimulated gene factor 3; ISG; IFN-stimulated gene; CREB; cyclic AMP-response element-binding protein

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2017 سفارش ترجمه

Subtyping of Type 1 Diabetes as Classified by Anti-GAD Antibody, IgE Levels, and Tyrosine kinase 2 (TYK2) Promoter Variant in the Japanese

Keywords: Type 1 diabetes (T1D); Anti-GAD; IgE; Tyrosine kinase 2 (TYK2); Th1/Th2; Virus; T1D; Type 1 diabetes; Th1; type 1 T helper; TYK2; Tyrosine kinase 2; HIES; hyper-IgE syndrome; Th2; type 2 T helper; Anti-GAD Ab; anti-glutamic acid decarboxylase antibody; YH

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2017 سفارش ترجمه

The JAK/STAT signaling pathway and photobiomodulation in chronic wound healing

Keywords: AP; activator protein; ATP; adenosine triphosphate; Ca2+; calcium ions; cAMP; cyclic adenosine monophosphate; Cox; cytochrome c oxidase; Cu; copper; Cyto c; cytochrome c; DNA; deoxyribonucleic acid; ECM; extracellular matrix; EGF; epidermal growth factor;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Functional analyses of the interaction of chicken interleukin 23 subunit p19 with IL-12 subunit p40 to form the IL-23 complex

Keywords: JAK; Janus kinase; STAT; signal transducer and activator of transcription; SOCS; suppressor of cytokine signaling; TYK2; tyrosine kinase 2; NF-κB; nuclear factor kappa B; C/EBP; CCAAT-enhancer-binding proteins; GATA-1; GATA-binding factor 1; AP-1; Activa

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2017 سفارش ترجمه

Identification of an imidazopyridine scaffold to generate potent and selective TYK2 inhibitors that demonstrate activity in an in vivo psoriasis model

Keywords: TYK2; Kinase; Psoriasis; Imidazopyridine; IL-23;

دانلود رایگان متن کامل مقاله ISI 20 صفحه سال انتشار : 2017 سفارش ترجمه

Analysis of JAK-STAT signaling pathway genes and their microRNAs in the intestinal mucosa of genetically disparate chicken lines induced with necrotic enteritis

Keywords: JAK; Janus kinase; STAT; signal transducer and activator of transcription; SOCS; suppressor of cytokine signaling; IL; interleukin; RT; reverse transcription; TYK2; tyrosine kinase 2; SH2 (PTPN); src homology 2-containing tyrosine phosphatase 2; PIAS; pro

دانلود رایگان متن کامل مقاله ISI 28 صفحه سال انتشار : 2017 سفارش ترجمه

Computer-aided identification of potential TYK2 inhibitors from drug database

Keywords: TYK2; Kinase inhibitor; Molecular docking; MD simulation; MM-PBSA

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

9H-Carbazole-1-carboxamides as potent and selective JAK2 inhibitors

Keywords: JAK2; JAK; JAK family selectivity; JAK1; JAK3; TYK2; Myeloproliferative disorders; Myeloproliferative neoplasms

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2015 سفارش ترجمه

Discovery of Tyk2 inhibitors via the virtual site-directed fragment-based drug design

Keywords: Tyk2; Inhibitor; Water-ring analysis; FBDD; STATs activation

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

Pancreatic adenocarcinoma upregulated factor (PAUF) confers resistance to pancreatic cancer cells against oncolytic parvovirus H-1 infection through IFNA receptor-mediated signaling

Keywords: PAUF; H-1 virus; IFNAR; Tyk2; Stat1;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

Investigation of genetic susceptibility to nonspecific digestive disorder between TYK2, JAK1, and STAT3 genes in rabbits

Keywords: TYK2; JAK1; STAT3; Genetic susceptibility; MDR; Rabbit;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

Human Pegivirus (HPgV; formerly known as GBV-C) inhibits IL-12 dependent natural killer cell function

Keywords: HPgV; GBV-C; NK cells; Tyk2; Immune modulation;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2015 سفارش ترجمه

Discovery of pyrrolo[1,2-b]pyridazine-3-carboxamides as Janus kinase (JAK) inhibitors

Keywords: JAK inhibitor; Pyrrolo[1,2-b]pyridazine; Janus kinase; JAK3; TYK2;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

The role of JAK-STAT signaling in adipose tissue function

Keywords: Brown and white adipose; Janus kinase; Immune cell; Cytokine; Tyk2; Obesity;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Stearoyl-CoA desaturase regulates inflammatory gene expression by changing DNA methylation level in 3T3 adipocytes

Keywords: SCD1; stearoyl-CoA desaturase 1; WAT; white adipose tissue; TNFα; tumor necrosis factor-α; IL6; interleukin 6; MCP1; monocyte chemoattractant protein 1; LPS; lipopolysaccharide; Il10ra; interleukin 10 receptor a; Il6st; interleukin 6 signal transducer;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2014 سفارش ترجمه

Short CommunicationInterleukin-10 prevents epithelial cell apoptosis by regulating IFNγ and TNFα expression in rhesus macaque colon explants

Keywords: AC-3; active caspase-3; IL-10; interleukin-10; HIV; human immunodeficiency virus; Th1; T-helper 1; JAK1; janus kinase 1; Tyk2; tyrosine kinase 2; SCID; severe combined immunodeficiency; EC; epithelial cells; RM; rhesus macaque; MAb; monoclonal antibody; r

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

The influence of non-HLA gene polymorphisms and interactions on disease risk in a Western Australian multiple sclerosis cohort

Keywords: APOE; Apolipoprotein E; CLEC-16A; C-type lectin domain family 16; CTLA-4; Cytotoxic T-lymphocyte antigen 4; ICAM-1; Intercellular adhesion molecule 1; IL2RA; Interleukin 2 receptor a; IL7R; Interleukin 7 receptor; IRF5; Interferon regulatory factor 5; STA

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

The Atlantic salmon protein tyrosine kinase Tyk2: Molecular cloning, modulation of expression and function

Keywords: aa; amino acid; bp; base pair; JAK; Janus kinase; Tyk2; Tyrosine kinase 2; IFN; Interferon; ss; Salmo salar; STAT; signal transducers and activators of the transcription; JH; janus homology; HK; head kidney; ISG's; interferon responsive genes; ISRE; int

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2013 سفارش ترجمه

Gene expression profiling for analysis acquired oxaliplatin resistant factors in human gastric carcinoma TSGH-S3 cells: The role of IL-6 signaling and Nrf2/AKR1C axis identification

Keywords: AKR1Cs; aldo-keto reductase family members (e.g. AKR1C1, AKR1C2, or AKR1C3); ARE; antioxidant response element; cisplatin; cis-diamminedichloroplatinum(II) (CDDP); ERCC-1; excision repair cross-complementing-1; ERK; extracellular signal-related kinase; FF

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2013 سفارش ترجمه

Janus kinase 2 - A novel negative regulator of estrogen receptor α function

Keywords: CA; constitutive active; CDK2; Cyclin dependent kinase 2; CDK7; Cyclin dependent kinase 7; CK2; Casein kinase 2; DCC; dextran-coated charcoal-treated; DNA-PK; DNA-dependent protein kinase; E2; 17β-estradiol; EGFR; Epidermal growth factor receptor; ER; es

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

The role of pseudokinases in cancer

Keywords: ALL; Acute Lymphoblastic Leukaemia; AML; Acute Myeloid Leukaemia; AMPK; 5′-Adenosine Monophosphate Activated Protein Kinase; ATF4; Activating Transcriptional Factor 4; ATP; Adenosine-5′-Triphosphate; BTICs; Brain Tumour-Initiating Cells; C/EBPα; CCAA

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2012 سفارش ترجمه

Inhibition of lipopolysaccharide-induced inducible nitric oxide synthase expression by endoplasmic reticulum stress

Keywords: ATF6; activating transcription factor 6; BFA; brefeldin A; CaM; calmodulin; 15dPGJ2; 15-deoxy-Δ12,14-prostaglandin J2; eIF2α; eukaryotic translation initial factor 2α; ER; endoplasmic reticulum; GAS; gamma-activated sequence; HAT; histone acetyltransfe

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2012 سفارش ترجمه

Clinical, immunological and genetic features in Taiwanese patients with the phenotype of hyper-immunoglobulin E recurrent infection syndromes (HIES)

Keywords: Hyper IgE recurrent infection syndromes (HIES); STAT3; TYK2; DOCK8; Primary immunodeficiency diseases (PIDs); Taiwan; Chinese;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه

Primary immunodeficiency diseases associated with increased susceptibility to viral infections and malignancies

Keywords: Immunodeficiency; viral infection; malignancies; X-linked lymphoproliferative syndrome; AR-HIES; Autosomal recessive hyper-IgE syndrome; CVID; Common variable immunodeficiency; DDR; DNA damage response; DOCK8; Dedicator of cytokinesis 8; EV; Epidermodyspl

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2011 سفارش ترجمه

2-Amino-aryl-7-aryl-benzoxazoles as potent, selective and orally available JAK2 inhibitors

Keywords: Janus kinase; JAK1; JAK2; JAK3; Tyk2; Kinase inhibitors; JAK2 inhibitor

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2010 سفارش ترجمه

Diamino-1,2,4-triazole derivatives are selective inhibitors of TYK2 and JAK1 over JAK2 and JAK3

Keywords: Tyrosine kinase 2; TYK2; Janus associated kinase; JAK1; JAK2; JAK3

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2010 سفارش ترجمه

Discovery and SAR of potent, orally available 2,8-diaryl-quinoxalines as a new class of JAK2 inhibitors

Keywords: Janus kinase; JAK1; JAK2; JAK3; Tyk2; Kinase inhibitors

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2010 سفارش ترجمه

Tyrosine kinase 2 interacts with the proapoptotic protein Siva-1 and augments its apoptotic functions

Keywords: Siva-1; Tyk2; B cell apoptosis;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2010 سفارش ترجمه

IFN-γ activated JAK1 shifts CD40-induced cytokine profiles in human antigen-presenting cells toward high IL-12p70 and low IL-10 production

Keywords: Dendritic cells; Monocytes; B-cells; Endothelial cells; CD40; CD40L; JAK; Tyk2; STAT; NF-κB; IRF-1; IRF-8; IL-12; IL-10

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2010 سفارش ترجمه

Human T-cell leukemia virus type 1 blunts signaling by interferon alpha

Keywords: HTLV; Type I interferon; STAT2; TYK2; Gag

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2008 سفارش ترجمه

Tyk2 mutation homologous to V617F Jak2 is not found in essential thrombocythaemia, although it induces constitutive signaling and growth factor independence

Keywords: Myeloproliferative diseases; Jak2; Tyk2; Polycythaemia vera; Essential thrombocythaemia

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2007 سفارش ترجمه

Identification and expression analysis of novel Jakmip1 transcripts

Keywords: Jakmip; janus kinase and microtubule interacting protein; FERM; band F erzin-radixin-moesin; Tyk2; tyrosine kinase 2; GABABR; gamma aminobutirric acid B receptor; EST; expressed sequence tag; RPE; retinal pigment epithelium; RT-PCR; reverse transcriptase-

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2007 سفارش ترجمه

Nonreceptor Tyrosine Kinases in Prostate

Keywords: Nonreceptor tyrosine kinase; prostate cancer; Src; FAK; ETK; Abl; v-Abl Abelson murine leukemia viral oncogene homolog; At; androgenindependent; Aid; v-akt murine thymoma viral oncogene homolog 1; AR; androgen receptor; ARG; Abelson-related gene; Bcr; bre

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2007 سفارش ترجمه

Jak2 and Tyk2 are necessary for lineage-specific differentiation, but not for the maintenance of self-renewal of mouse embryonic stem cells

Keywords: mESCs; Self-renewal; LIF-induced Jak1/STAT3 signaling pathway; Jak2; Tyk2; RNAi; Microarray; Differentiation; Lineage specification

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2006 سفارش ترجمه