Keywords: تریروزین کیناز; AGEs; advanced glycation end products; CEL; Nε-(carboxyethyl) lysine; CMA; NÏ-(carboxymethyl) arginine; CML; Nε-(carboxymethyl) lysine; H2O2; hydrogen peroxide; HCC; hepato-cellular carcinoma-; HMGB1; high mobility group box-1; NAFLD; nonalcoholic fatt
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Keywords: تریروزین کیناز; Breast cancer; Cell signaling; Proteomics; SILAC; Tyrosine kinases
Keywords: تریروزین کیناز; Quinazolinones; Tyrosine kinases; Multi kinase inhibitors; FibrosisCAN, cerium ammonium nitrate; CD, Crohn's Desease; COL1A1, prepro-alpha 1 collagen; DMF, dimethylformamide; ECM, extracellular matrix; EGFR, epidermal growth factor receptor; FGFR1, type 1
Keywords: تریروزین کیناز; Mast cells; Stabilisers; Immunoglobulin E (IgE); Tyrosine kinases
Keywords: تریروزین کیناز; Soybean; Genistein; ERα/ERβ; Tyrosine kinases; miRNA
Keywords: تریروزین کیناز; Atomistic simulation; In silico screening; High-throughput docking; Bromodomains; Tyrosine kinases; Proteases
A DFT study of inclusion complexes of substituted calix[n]arenes with dasatinib and lapatinib
Keywords: تریروزین کیناز; Docking; Density functional theory; Tyrosine kinases; Host-guest; Bioavailability;
ROS-dependent activation of RhoA/Rho-kinase in pulmonary artery: Role of Src-family kinases and ARHGEF1
Keywords: تریروزین کیناز; Vascular smooth muscle; Tyrosine kinases; Src-family kinases; Reactive oxygen species; Hypoxia; Rho-kinase; Guanine nucleotide exchange factors; Pulmonary artery;
Theoretical assessment of calix[n]arene as drug carriers for second generation tyrosine kinase inhibitors
Keywords: تریروزین کیناز; Calixarene; Inclusion complex; Bioavailability; Tyrosine kinases; Interaction energy; Implicit solvation;
Loss of discoidin domain receptor 1 (DDR1) via CpG methylation during EMT in epithelial ovarian cancer
Keywords: تریروزین کیناز; DDR1; discoidin domain receptor 1; DDR2; discoidin domain receptor 2; EMT; epithelial-mesenchymal transition; EOC; epithelial ovarian cancer; RT-qPCR; reverse transcription quantitative polymerase chain reaction; ELISA; enzyme-linked immunosorbent assay;
The human tyrosine kinase Kit and its gatekeeper mutant T670I, show different kinetic properties: Implications for drug design
Keywords: تریروزین کیناز; Kit; Enzyme kinetics; Tyrosine kinases; Drug resistance;
Ensemble docking and molecular dynamics identify knoevenagel curcumin derivatives with potent anti-EGFR activity
Keywords: تریروزین کیناز; EGFR; epidermal growth factor receptor; TK; tyrosine kinases; NSCLC; non-small-cell lung carcinoma; NCEs; new chemical entities; MD; molecular dynamics; RMSD; root mean square deviation; EGFR; Tyrosine kinase; Curcumin; Ensemble docking; Molecular dynamic
Novel synthetic 9-benzyloxyacridine analogue as both tyrosine kinase and topoisomerase I inhibitor
Keywords: تریروزین کیناز; Acridine; Topoisomerases; Tyrosine kinases; Antitumor; DNA-binding
New insights into Dok-4 PTB domain structure and function
Keywords: تریروزین کیناز; Cell signaling; Adapter proteins; Dok-4; Ret; Tyrosine kinases; Phosphotyrosine binding domains; Ship1
Osteoarthritis-associated basic calcium phosphate crystals induce pro-inflammatory cytokines and damage-associated molecules via activation of Syk and PI3 kinase
Keywords: تریروزین کیناز; BCP, basic calcium phosphate; MSU, monosodium urate; Syk, spleen tyrosine kinase; MMP, matrix metalloprotease; NLRP3, Nod-like receptor protein; OA, osteoarthritisOsteoarthritis; Inflammation; Tyrosine kinases; Danger molecules; Cytokines
Muscle Specific Kinase: Organiser of synaptic membrane domains
Keywords: تریروزین کیناز; MuSK; LRP4; Synapse formation; Tyrosine kinases; Agrin;
Molecular pathways of platelet factor 4/CXCL4 signaling
Keywords: تریروزین کیناز; Signal transduction; Chemokines; CXCL4; MAP kinases; Sphingosine kinases; Tyrosine kinases; GTPases; Neutrophils; Monocytes; CXCR3-B
Age-related defects in the cytoskeleton signaling pathways of CD4 T cells
Keywords: تریروزین کیناز; T lymphocytes; Aging; Cytoskeleton; Tyrosine kinases; Signal transduction; Cellular activation; TCR signaling
Tyrosine kinase inhibitors for the treatment of acute myeloid leukemia: Delineation of anti-leukemic mechanisms of action
Keywords: تریروزین کیناز; Apoptosis; Differentiation; Epidermal growth factor receptor; Tyrosine kinases; Erlotinib; Lapatinib
Role of Abl and Src family kinases in actin-cytoskeletal rearrangements induced by the Helicobacter pylori CagA protein
Keywords: تریروزین کیناز; Helicobacter pylori; Signalling; Cancer; Type IV secretion; Vacuolating cytotoxin; CagA; cagPAI; Tyrosine kinases; Src; Abl; Cortactin; Vinculin; Ezrin; Csk
Dual Src and Abl inhibitors target wild type Abl and the AblT315I Imatinib-resistant mutant with different mechanisms
Keywords: تریروزین کیناز; Src; Abl; Anticancer chemotherapy; Drug resistance; Enzyme kinetics; Tyrosine kinases
The Role of VEGF Pathways in Human Physiologic and Pathologic Angiogenesis
Keywords: تریروزین کیناز; angiogenesis; human; vascular endothelial growth factor (VEGF); platelet derived growth factor (PDGF); VEGF receptors; tyrosine kinases; mechanisms
A Multitude of Kinases-Which are the Best Targets in Treating Rheumatoid Arthritis?
Keywords: تریروزین کیناز; MAPKs; Tyrosine kinases; IKK; Jak; Syk; Small-molecule inhibitors;
Age-related changes in lck–Vav signaling pathways in mouse CD4 T cells
Keywords: تریروزین کیناز; T lymphocytes; Aging; Cytoskeleton; Tyrosine kinases; Signal transduction; Cellular activation; TCR signaling
Crystal structures of free and ligand-bound focal adhesion targeting domain of Pyk2
Keywords: تریروزین کیناز; Tyrosine kinases; Cell signaling; Focal adhesion; Cell adhesion
BRK phosphorylates PSF promoting its cytoplasmic localization and cell cycle arrest
Keywords: تریروزین کیناز; Tyrosine kinases; BRK; Breast cancer; PSF; RNA-binding proteins; Mass spectrometry; Epidermal growth factor
Tyrosine kinases as targets in rheumatoid arthritis
Keywords: تریروزین کیناز; Rheumatoid arthritis; Tyrosine kinases; Tyrosine kinases inhibitors; Dasatinib; Imatinib
Growth hormone-induced production of cytokines in murine peritoneal macrophages in vitro: Role of JAK/STAT, PI3K, PKC and MAP kinases
Keywords: تریروزین کیناز; Growth hormone; Macrophage; Cytokines; Tyrosine kinases; ERK1/2; JNK MAP kinaseGH, growth hormone; MAPK, mitogen-activated protein kinases; JAK, Janus kinase; PI3K, phosphoinositide 3-kinase; PKC, protein kinase C; JNK, c-Jun N-terminal kinases; ERK, extr
Second-Generation Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Non-small Cell Lung Cancer
Keywords: تریروزین کیناز; Non-small cell lung cancer; Epidermal growth factor receptor; Tyrosine kinases
Chlamydia trachomatis tarp is phosphorylated by src family tyrosine kinases
Keywords: تریروزین کیناز; Chlamydia trachomatis; Src; Abl; Tyrosine kinases; Tarp
2-(1H-Imidazol-4-yl)ethanamine and 2-(1H-pyrazol-1-yl)ethanamine side chain variants of the IGF-1R inhibitor BMS-536924
Keywords: تریروزین کیناز; IGF-1R; Tyrosine kinases; Anticancer agent; Benzimidazole; Haloimidazole; Halopyrazole
Inhibition of tyrosine kinase activity prevents the adhesive and cohesive properties of platelets and the expression of procoagulant activity in response to collagen
Keywords: تریروزین کیناز; tyr47, tyrphostin 47; Col-I, type I collagen; T, thrombinCollagen; Cytoskeleton; Fibrin formation; Platelet adhesion; Tyrosine kinases
Development of new pyrrolopyrimidine-based inhibitors of Janus kinase 3 (JAK3)
Keywords: تریروزین کیناز; JAK3; Janus Kinase; Tyrosine kinases; Cytokines; Pyrrolopyrimidine
Identification of Dok-4b, a Dok-4 splice variant with enhanced inhibitory properties
Keywords: تریروزین کیناز; Dok-4; Fyn; Ret; Epithelial growth factor receptor; Tyrosine kinases; Elk-1; Erk; Adapter molecules; Splice variant; Epithelial cells;
Peptide modulators of Src activity in G1 regulate entry into S phase and proliferation of NIH 3T3 cells
Keywords: تریروزین کیناز; Src; RACK1; PKC; Tyrosine kinases; G1/S transition; Cell cycle regulation;
Vasculogenic mimicry: Current status and future prospects
Keywords: تریروزین کیناز; Vasculogenic mimicry; Uveal melanoma; Linearly patterned programmed cell necrosis; Highly aggressive melanoma; Metalloproteinases; Laminin; VE-cadherin; Tyrosine kinases; Three-stage phenomenon; VM-targeted therapy
The effect of angiotensin 1–7 on tyrosine kinases activity in rat anterior pituitary
Keywords: تریروزین کیناز; Angiotensin 1–7; Tyrosine kinases; Losartan; PD123319; Angiotensin receptors
Novel C-3 N-urea, amide, and carbamate dihydroindazolo[5,4-a]pyrrolo[3,4-c]carbazole analogs as potent TIE-2 and VEGF-R2 dual inhibitors
Keywords: تریروزین کیناز; Antiangiogenenic therapy; Anti-tumor; Tyrosine kinases; TIE-2; VEGF-R2
Involvement of the SH3 domain in Ca2+-mediated regulation of Src family kinases
Keywords: تریروزین کیناز; c-Src; c-Yes; Tyrosine kinases; Calcium; MDCK cells; SH3 domain; EDTA; ethylene dinitrilo-tetraacetic acid; GST; glutathione-S-transferase; GT; glutathione; IVKA; in vitro kinase assays; IVRA; in vitro reconstitution assays; MDCK; Madin-Darby canine cel
Oncogenic inflammation and autoimmune disease
Keywords: تریروزین کیناز; Cytokines; Fusion protein; Inflammation; Oncogene; T cells; Tyrosine kinases
Phosphoproteomic analysis of AML cell lines identifies leukemic oncogenes
Keywords: تریروزین کیناز; AML; Phosphopeptide; Tyrosine kinases; Leukemia
Mechanisms of Cell Volume Regulation in Hypo-osmolality
Keywords: تریروزین کیناز; Osmosensitive channels; Osmotransduction; Taurine; Tyrosine kinases; Volume sensor;
Lipopolysaccharide-induced c-Src expression plays a role in nitric oxide and TNFα secretion in macrophages
Keywords: تریروزین کیناز; LPS; Macrophage; Tyrosine kinases; Signal transduction; Inflammation
Redox modulation of tyrosine phosphorylation-dependent neutrophil adherence to endothelial cells
Keywords: تریروزین کیناز; Reactive oxygen species; Neutrophils; Endothelial cells; Adhesion; Adhesion molecules; Tyrosine phosphorylation; Tyrosine kinases; Focal adhesion kinase;
Lyn contributes to regulation of multiple Kit-dependent signaling pathways in murine bone marrow mast cells
Keywords: تریروزین کیناز; Kit; Stem cell factor; Lyn; Tyrosine kinases; Signal transduction; Hematopoiesis;
Two different pathways link G-protein-coupled receptors with tyrosine kinases for the modulation of growth and survival in human hematopoietic progenitor cells
Keywords: تریروزین کیناز; AG 82; AG 490, tyrphostin tyrosine kinase inhibitors; BFU-E; burst forming unit-erythroid; CXCR4; CXC-chemokine receptor 4, specifically recognizing CXCL12; Epo; erythropoietin; Flt-3L; ligand of flt-3 receptor; G-CSF; granulocyte colony-stimulating facto