کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3342637 1214298 2006 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Oncogenic inflammation and autoimmune disease
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Oncogenic inflammation and autoimmune disease
چکیده انگلیسی

Many models exist to explain the induction and perpetuation of autoimmune diseases. Despite their validation in a variety of animal models, the basis for autoimmune disease in humans remains unknown. Here, we propose that an important aspect of autoimmune disease is the active participation of the target organ due to endogenously produced co-stimulatory factors that cause prolonged antigen presentation and lymphocyte activation. Evidence suggests that a major source of such endogenous signaling comes from newly transformed cells within the target organ that produce pro-inflammatory factors.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Autoimmunity Reviews - Volume 6, Issue 2, December 2006, Pages 107–114
نویسندگان
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