کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1902378 1045742 2011 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Age-related defects in the cytoskeleton signaling pathways of CD4 T cells
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
پیش نمایش صفحه اول مقاله
Age-related defects in the cytoskeleton signaling pathways of CD4 T cells
چکیده انگلیسی

It has been postulated that the cytoskeleton controls many aspects of T cell function, including activation, proliferation and apoptosis. Recent advances in our understanding of F-actin polymerization and the Ezrin-Radixin-Moesin (ERM) family of cytoskeleton signal proteins have provided new insights into immunological synapse formation during T cell activation. During aging there is a significant decline of T cell function largely attributable to declines in activation of CD4 T cells and defects in the formation of the immunological synapse. Here we discuss recent progress in the understanding of how aging alters F-actin and ERM proteins in mouse CD4 T cells, and the implications of these changes for the T cell activation process.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Ageing Research Reviews - Volume 10, Issue 1, January 2011, Pages 26–34
نویسندگان
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