Keywords: سیستم Ubiquitin-proteasome; Spinocerebellar ataxia type 3; Ataxin-3; Mass spectrometry; Protein interaction; Mitochondria; Atx3; Ataxin-3; CHIP; C-terminus of 70Â kDa heat shock protein; E3s; E3 ubiquitin-protein ligases; HD; Huntington's disease; polyQ; polyglutamine; UPS; ubiquiti
مقالات ISI سیستم Ubiquitin-proteasome (ترجمه نشده)
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Keywords: سیستم Ubiquitin-proteasome; AE; Adverse event; BIPN; Bortezomib-induced peripheral neuropathy; C-L; Caspase-like; CFZ; Carfilzomib; ChT-L; Chymotrypsin-like action; IRd; Ixazomib, lenalidomide, and dexamethasone; LG; Leaving group; MM; Multiple myeloma; MTD; Maximum tolerated dose;
Keywords: سیستم Ubiquitin-proteasome; AD; Alzheimer disease; ATP; adenosine triphosphate; AMP; adenosine monophosphate; AMPK; AMP-activated protein kinase; BDNF; brain derived neurotrophic factor; CMA; chaperone-mediated autophagy; CR; caloric restriction; Ex; exercise; GABA; gamma-aminobutyr
Keywords: سیستم Ubiquitin-proteasome; 6-OHDA; 6-hydroxydopamine; α-syn; α-synuclein; ACC; Anterior Cingulate Cortex; ADMA; asymmetric dimethylarginine; Alda-1; N-(1,3-Benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide; Aldh1/Aldh2; aldehyde dehydrogenases 1/2; ALDH2; mitochondrial aldehyde dehyd
Keywords: سیستم Ubiquitin-proteasome; Atg; autophagy related; AD; Alzheimer's disease; HD; Huntigton's disease; PD; Parkinson's disease; UPS; ubiquitin-proteasome system; CMA; chaperone-mediated autophagy; ER; endoplasmic reticulum; FD; fascia dentate; LC3; microtubule-associated light
Keywords: سیستم Ubiquitin-proteasome; Notch; Ubiquitin-proteasome system; Degradation; Breast cancer; Therapy;
Keywords: سیستم Ubiquitin-proteasome; Insulin resistance; Autophagy; Ubiquitin-proteasome system; Apoptosis; H2O2; Hindlimb unloading; Xanthine oxidase; Exercise
Keywords: سیستم Ubiquitin-proteasome; ATF4; activating transcription factor-4; ATF6α; activating transcription factor-6α; EB1; end binding protein-1; EDEM; ER degradation-enhancing α-like protein; ER; endoplasmic reticulum; ERAD; ER-associated degradation; GCN2; general control non-derepre
Keywords: سیستم Ubiquitin-proteasome; Ca2+ channel; K+ channel; Ca2+-activated Clâ channel; Transcription; Pre-mRNA splicing; Protein degradation; AD; Alzheimer's disease; ADPR; ADP ribose; AITC; allyl isothiocyanate; AKAP; A-kinase anchoring protein; AMPK; 5â² AMP-activated protein kinase
Keywords: سیستم Ubiquitin-proteasome; DOX; doxorubicin; ROS; reactive oxygen species; UPS; ubiquitin-proteasome system; E1s; ubiquitin activating enzymes; E2s; ubiquitin conjugating enzymes; E3s; ubiquitin ligases; DUBs; deubiquitinases; Cardiotoxicity; Doxorubicin; Apoptosis; Ubiquitin-prote
Keywords: سیستم Ubiquitin-proteasome; Ubiquitin-proteasome system; Nuclear transport; Nuclear protein degradation; Proteasome assembly; Quiescence; Proteasome storage granuli;
Keywords: سیستم Ubiquitin-proteasome; Multiple myeloma; Bortezomib; Resistance; Ubiquitin-proteasome system; Autoimmune diseases; Proteostasis
Keywords: سیستم Ubiquitin-proteasome; Silica nanoparticles; Parkinson diseases; Alpha-synuclein; Ubiquitin-proteasome system; Autophagy
Loss of NRF-2 and PGC-1α genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration
Keywords: سیستم Ubiquitin-proteasome; ER; endoplasmic reticulum; AMD; age-related macular degeneration; RPE; retinal pigment epithelium; PUFAs; polyunsaturated fatty acids; ROS; reactive oxygen species; NRF-2; nuclear factor-erythroid 2-related factor-2; ARE; antioxidant response element; Kea
Ethanol withdrawal limits fear memory reactivation-induced molecular events associated with destabilization phase: Influence of d-cycloserine
Keywords: سیستم Ubiquitin-proteasome; Ethanol withdrawal; Fear memory reconsolidation; NMDA receptor; Ubiquitin-proteasome system; Basolateral amygdala;
Ubiquitin-activating enzyme E1 inhibitor PYR-41 retards sperm enlargement after fusion to the egg
Keywords: سیستم Ubiquitin-proteasome; Ubiquitin-proteasome system; UBE1; PYR-41; Sperm enlargement; β-catenin;
ZSCAN4 is negatively regulated by the ubiquitin-proteasome system and the E3 ubiquitin ligase RNF20
Keywords: سیستم Ubiquitin-proteasome; ZSCAN4; RNF20; Proteasome; Lysine-48 ubiquitination; Cancer; Stem cells; Telomeres; UPS; ubiquitin-proteasome system; ES cells; embryonic stem cells; iPS cells; induced pluripotent stem cells; Dox; doxycycline; CHX; cycloheximide; co-IP; co-immunoprecipit
Aim for the core: suitability of the ubiquitin-independent 20S proteasome as a drug target in neurodegeneration
Keywords: سیستم Ubiquitin-proteasome; 20S; core 20S proteasome; AD; Alzheimer's disease; ALS; amyotrophic lateral sclerosis; ATP; adenosine triphosphate; BBB; blood-brain barrier; DUB; deubiquitinating enzyme; HbYX; hydrophobic-tyrosine-unspecified residue 'X'; IDP; intrinsically disorder
Ubiquitin C-Terminal Hydrolase L1 is required for regulated protein degradation through the ubiquitin proteasome system in kidney
Keywords: سیستم Ubiquitin-proteasome; immune-complex nephritis; proteasome abundance; ubiquitin-C-terminal hydrolase-L1; ubiquitin-proteasome system;
The physiological role of the free 20S proteasome in protein degradation: A critical review
Keywords: سیستم Ubiquitin-proteasome; Ubiquitin-proteasome system; Proteasomal complexes; Ubiquitin- and ATP-independent protein degradation;
Paradoxical effects of mutant ubiquitin on Aβ plaque formation in an Alzheimer mouse model
Keywords: سیستم Ubiquitin-proteasome; Mutant ubiquitin; Ubiquitin-proteasome system; γ-Secretase; Amyloid-β; Behavior; Alzheimer's disease;
PSMD2 regulates breast cancer cell proliferation and cell cycle progression by modulating p21 and p27 proteasomal degradation
Keywords: سیستم Ubiquitin-proteasome; Breast cancer; Ubiquitin-proteasome system; PSMD2; Cell cycle; p21; p27; BC; breast cancer; CI; confidence interval; DMFS; distant-metastasis-free survival; DUBs; deubiquitinating enzymes; E1s; Ub-activating enzymes; E2s; Ub-conjugating enzymes; E3s; Ub-p
Deubiquitylating enzymes as cancer stem cell therapeutics
Keywords: سیستم Ubiquitin-proteasome; Protein-IPSC; protein-induced pluripotent stem cells; CSCs; cancer stem cells; DUBs; deubiquitylating enzymes; ESCs; embryonic stem cells; PTMs; post-translational modifications; AML; acute myelogenous leukemia; USP/UBP; ubiquitin-specific processing prot
An herbal formula consisting of Schisandra chinensis (Turcz.) Baill, Lycium chinense Mill and Eucommia ulmoides Oliv alleviates disuse muscle atrophy in rats
Keywords: سیستم Ubiquitin-proteasome; Muscle atrophy; Traditional medicine; Synergy; Ubiquitin-proteasome system; C2C12;
Aberrant subcellular localization of SQSTM1/p62 contributes to increased vulnerability to proteotoxic stress recovery in Huntington's disease
Keywords: سیستم Ubiquitin-proteasome; ATF4; activating transcription factor 4; BSA; bovine serum albumin; CHX; cycloheximide; CQ; hydroxychloroquine; HD; Huntington's disease; HDAC6; histone deacetylase 6; Htt; huntingtin; mHtt; mutant huntingtin; Lamp1; lysosomal associated membrane protein
Identification of UBact, a ubiquitin-like protein, along with other homologous components of a conjugation system and the proteasome in different gram-negative bacteria
Keywords: سیستم Ubiquitin-proteasome; UBact; Ubiquitin; Pup; Proteasome; Bacteria; Dop; Deamidase of Pup; Mpa; mycobacterial proteasome ATPase; PafA; Proteasome accessory factor A; PPS; Pup-proteasome system; PrcA; proteasome subunit α; PrcB; proteasome subunit β; Pup; prokaryotic ubiquitin
Molecular chaperones of the Hsp70 family assist in the assembly of 20S proteasomes
Keywords: سیستم Ubiquitin-proteasome; Proteasome; Protein assembly; Molecular chaperone; Yeast; Heat shock protein; Hsp70; CP; core particle; RP; regulatory particle; UPS; ubiquitin-proteasome system; MCN; molecular chaperone network; ICAR; immobilized-cobalt affinity resin;
Orobol derivatives and extracts from Cudrania tricuspidata fruits protect against 6-hydroxydomamine-induced neuronal cell death by enhancing proteasome activity and the ubiquitin/proteasome-dependent degradation of α-synuclein and synphilin-1
Keywords: سیستم Ubiquitin-proteasome; 6-OHDA; 6-hydroxydomamine; PD; Parkinson's disease; PARP; poly (ADP-ribose) polymerase; ROS; reactive oxygen species; UPP; ubiquitin-proteasome pathway; UPS; ubiquitin-proteasome system; CTE50; 50% ethanol extract from Cudrania tricuspidata fruits; OB;
Normal human cell proteins that interact with the adenovirus type 5 E1B 55Â kDa protein
Keywords: سیستم Ubiquitin-proteasome; Human adenovirus type 5 (HAdV-C5); E1B 55Â kDa protein; Normal human cells; Mass spectrometry; Type I interferons; Ubiquitin-proteasome system; RNA metabolism;
Mammalian target of rapamycin signaling and ubiquitin proteasome-related gene expression in 3 different skeletal muscles of colostrum- versus formula-fed calves
Keywords: سیستم Ubiquitin-proteasome; mammalian target of rapamycin; ubiquitin-proteasome system; muscle; neonatal calf;
Simple and efficient knockdown of His-tagged proteins by ternary molecules consisting of a His-tag ligand, a ubiquitin ligase ligand, and a cell-penetrating peptide
Keywords: سیستم Ubiquitin-proteasome; Protein knockdown; His-tag-fused protein; Ubiquitin-proteasome system; Carrier peptide;
Withaferin A induced impaired autophagy and unfolded protein response in human breast cancer cell-lines MCF-7 and MDA-MB-231
Keywords: سیستم Ubiquitin-proteasome; AO; Acridine orange; AVOs; Acidic vesicular organelles; CT; Chymotrypsin; LC3; Microtubule associated light chain 3; MDC; Mono-Dansyl-Cadaverine; UPS; Ubiquitin-proteasome system; WA; Withaferin A; WT; Wortmannin; EtBr; Ethidium Bromide; SQSTM1; Sequestos
UCHL1 Regulates Melanogenesis through Controlling MITF Stability in Human Melanocytes
Keywords: سیستم Ubiquitin-proteasome; DCT; dopachrome tautomerase; GFP; green fluorescent protein; MITF; microphthalmia-associated transcription factor; MNT-1; human melanoma cells; NHEM; normal human primary epidermal melanocyte; siRNA; small interfering RNA; TRP-1; tyrosinase-related protei
Postnatal Proteasome Inhibition Promotes Amyloid-β Aggregation in Hippocampus and Impairs Spatial Learning in Adult Mice
Keywords: سیستم Ubiquitin-proteasome; APP-CTFβ; amyloid precursor protein C-terminal fragments; EDTA; ethylenediaminetetraacetic acid; EGTA; (ethylene glycol-bis(β-aminoethyl ether)-N,N,Nâ²,Nâ²-tetraacetic acid; LTP; long-term potentiation; MVBs; multivesicular bodies; MWM; Morris water m
Structure and functions of the chaperone-like p97/CDC48 in plants
Keywords: سیستم Ubiquitin-proteasome; ADIN; antibody-dependent intracellular neutralization; ARF; ADP ribosylation factor; AAAÂ + ATPase; ATPase associated with diverse cellular activities; CDC48; cell division cycle 48; CAD; chromatin associated degradation; ER; endoplasmic reticulum; ERAD;
The core ubiquitin system of mandarin fish, Siniperca chuatsi, can be utilized by infectious spleen and kidney necrosis virus
Keywords: سیستم Ubiquitin-proteasome; Ubiquitin-proteasome system; Mandarin fish; ISKNV; HECT E3; RING E3; Immune evasion;
UBE2S associated with OSCC proliferation by promotion of P21 degradation via the ubiquitin-proteasome system
Keywords: سیستم Ubiquitin-proteasome; APC/C; Cell cycle; G2/M arrest; Oral squamous cell carcinoma; P21; Ubiquitin-proteasome system;
Sub-cellular localization specific SUMOylation in the heart
Keywords: سیستم Ubiquitin-proteasome; AMPK; adenosine monophosphate-activated protein kinase; CAMKK; calcium-calmodulin-activated protein kinase kinase; CHIP; carboxyl terminus of HSP70-interacting protein; CVD; cardiovascular disease; cTnI; cardiac troponin I; d-flow; disturbed flow; DeSI; d
Targeting chaperones, heat shock factor-1, and unfolded protein response: Promising therapeutic approaches for neurodegenerative disorders
Keywords: سیستم Ubiquitin-proteasome; 17-AAG; 17-(allylamino)-17-demethoxygeldanamycin (tanespimycin); 17-DMAG; 17- dimethylaminoethylamino-17-demethoxygeldanamycin (alvespimycin); AAV; adeno-associated virus; Aβ; amyloid-β; AD; Alzheimer's disease; ALS; amyotrophic lateral sclerosis; APP;
The ubiquitination of serotonin transporter in lymphoblasts derived from fluvoxamine-resistant depression patients
Keywords: سیستم Ubiquitin-proteasome; MDD; major depressive disorder; SERT; serotonin transporter; MAGE-D1; melanoma antigen gene-D1; EBV; Epstein-Barr virus; HAM-D; Hamilton depression scale; UPS; ubiquitin-proteasome system; Major depressive disorder; Serotonin transporter; Ubiquitination
UBE2D2 is not involved in MuRF1-dependent muscle wasting during hindlimb suspension
Keywords: سیستم Ubiquitin-proteasome; UPS; ubiquitin proteasome system; HS; hindlimb suspension; MuRF1; muscle ring finger protein-1; UBE2D2; ubiquitin-conjugating enzyme E2 D2; UBE2B; ubiquitin-conjugating enzyme E2 B; MHC; myosin heavy chain; SPR; surface plasmon resonance; Y2H; yeast two-h
PEK-1 is crucial for hormesis induced by inhibition of the IRE-1/XBP-1 pathway in the Caenorhabditis elegans mev-1 mutant
Keywords: سیستم Ubiquitin-proteasome; Proteostasis; Unfolded protein response; Proteasome; Hormesis; Caenorhabditis elegans; ABU; activated in blocked unfolded protein response; ANOVA; analysis of variance; ATF-6; activating transcription factor 6; BiP; immunoglobulin binding protein; C. ele
Mutants of collagen-specific molecular chaperone Hsp47 causing osteogenesis imperfecta are structurally unstable with weak binding affinity to collagen
Keywords: سیستم Ubiquitin-proteasome; Osteogenesis imperfecta; Collagen; Molecular chaperone Hsp47; Chemical chaperone; ER stress; ER; endoplasmic reticulum; OI; Osteogenesis imperfecta; UPS; ubiquitin-proteasome system; HMW; high molecular weight;
Arabidopsis Tóxicos en Levadura 78 (AtATL78) mediates ABA-dependent ROS signaling in response to drought stress
Keywords: سیستم Ubiquitin-proteasome; Ubiquitin-proteasome system (UPS); RING-type E3 ligase (RING); Drought stress; Reactive oxygen species (ROS); Arabidopsis Tóxicos en Levadura (ATL); ABA-dependent signaling; ATL; Arabidopsis Tóxicos en Levadura; UPS; Ubiquitin-Proteasome System; ROS; Re
On the linkage between the ubiquitin-proteasome system and the mitochondria
Keywords: سیستم Ubiquitin-proteasome; Ubiquitin-proteasome system; Mitochondria; Ubiquitination; Protein degradation; Proteasome; Protein–protein interactionSCUD, Saccharomyces cerevisiae ubiquitination database; GO, gene ontology; DUDE, database of ubiquitinating and deubiquitinating eznymes
Baicalein inhibits α-synuclein oligomer formation and prevents progression of α-synuclein accumulation in a rotenone mouse model of Parkinson's disease
Keywords: سیستم Ubiquitin-proteasome; PD; Parkinson disease; α-syn; α-synuclein; SN; substantia nigra; LBs; Lewy bodies; PFA; paraformaldehyde; TH; tyrosine hydroxylase; PBS; phosphate buffered saline; ChAT; choline acetyltransferase; HPLC; high performance liquid chromatography; DA; dopami
Cullin 5-RING E3 ubiquitin ligases, new therapeutic targets?
Keywords: سیستم Ubiquitin-proteasome; E3 ubiquitin ligase; Cullin RING ligase; Ubiquitin-proteasome system; Therapeutic targets; ASB; ankyrin repeat-containing proteins with a SOCS box; β-Trcp; β-transducin repeat-containing protein; BTB; bric-a-brac; CIS1; cytokine-inducible Src homology
Atypical ubiquitination by E3 ligase WWP1 inhibits the proteasome-mediated degradation of mutant huntingtin
Keywords: سیستم Ubiquitin-proteasome; Huntington's disease; Huntingtin; WWP1; E3 ligase; Ubiquitin-proteasome system; Ubiquitination
Hepatitis C virus core protein inhibits E6AP expression via DNA methylation to escape from ubiquitin-dependent proteasomal degradation
Keywords: سیستم Ubiquitin-proteasome; Core protein; DNA methylation; E6-associated protein; Hepatitis C virus; Ubiquitin-proteasome system;
Cardiac ubiquitin ligases: Their role in cardiac metabolism, autophagy, cardioprotection and therapeutic potential
Keywords: سیستم Ubiquitin-proteasome; ATG; autophagy-related gene; AMPK; AMP activated protein kinase; BECN1; beclin1; b-TrCP; beta-transducin repeat-containing protein; Cbl; Casitas B-lineage lymphoma; CHIP; Carboxyl terminus of Hsc70 interacting protein; CHMP2B; charged multivesicular body