Functions of PARylation in DNA Damage Repair Pathways
Keywords: یوبی کوئیتینه شدن ; Poly ADP-ribosylation; PARPs; DNA damage response; PAR-binding modules; Ubiquitination
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Negative regulation of TCR signaling by ubiquitination of Zap-70 Lys-217
Keywords: یوبی کوئیتینه شدن ; TCR; T cell receptor; Zap-70; zeta-chain associated protein of 70Â kDa; Zap-70; Ubiquitination; TCR signaling;
Atypical ubiquitination by E3 ligase WWP1 inhibits the proteasome-mediated degradation of mutant huntingtin
Keywords: یوبی کوئیتینه شدن ; Huntington's disease; Huntingtin; WWP1; E3 ligase; Ubiquitin-proteasome system; Ubiquitination
Serum- and glucocorticoid-inducible kinase SGK2 regulates human organic anion transporters 4 via ubiquitin ligase Nedd4-2
Keywords: یوبی کوئیتینه شدن ; Organic anion transporter; Drug transport; Regulation; Serum and glucocorticoid-inducible kinase; Ubiquitin ligase; Ubiquitination
The long N-terminus of the human monocarboxylate transporter 8 is a target of ubiquitin-dependent proteasomal degradation which regulates protein expression and oligomerization capacity
Keywords: یوبی کوئیتینه شدن ; MCT8; N-terminus; Ubiquitination; Degradation; Oligomerizationaa, amino acid; AHDS, Allan-Herndon-Dudley Syndrome; GFP, green fluorescent protein; MCT8, monocarboxylate transporter 8; MFS, major facilitator superfamily; reverse T3, 3,3′,5′-tri-iodothyroni
Activity dependent internalization of the glutamate transporter GLT-1 mediated by β-arrestin 1 and ubiquitination
Keywords: یوبی کوئیتینه شدن ; Intracellular trafficking; Endocytosis; Glutamate; Ubiquitination; Transport;
c-Cbl-mediated ubiquitination of IRF3 negatively regulates IFN-β production and cellular antiviral response
Keywords: یوبی کوئیتینه شدن ; c-Cbl; IRF3; Ubiquitination; Antiviral response;
A novel ubiquitin-protein ligase E3 functions as a modulator of immune response against lipopolysaccharide in Pacific oyster, Crassostrea gigas
Keywords: یوبی کوئیتینه شدن ; Crassostrea gigas; Ubiquitination; Immune response; Lipopolysaccharide stimulation; Ub-protein ligase E3
Genome-wide analysis of RING finger proteins in the smallest free-living photosynthetic eukaryote Ostreococus tauri
Keywords: یوبی کوئیتینه شدن ; Microalga; RING domain; E3 ligase; Ubiquitination; Metal ligand;
A bioluminescent assay for monitoring conjugation of ubiquitin and ubiquitin-like proteins
Keywords: یوبی کوئیتینه شدن ; Ubiquitination; Luminescent detection; Assay development; AMP detectionUb, ubiquitin; ATP, adenosine triphosphate; E1/2/3, enzyme 1/2/3; AMP, adenosine monophosphate; Ubl, ubiquitin-like; SUMO, small ubiquitin-like modifier; NEDD8, neural precursor cell-e
Investigation of the molecular mechanism of δ-catenin ubiquitination: Implication of β-TrCP-1 as a potential E3 ligase
Keywords: یوبی کوئیتینه شدن ; Ubiquitination; δ-Catenin; β-TrCP-1
Anti-cancer effect of (-)-epigallocatechin-3-gallate (EGCG) in head and neck cancer through repression of transactivation and enhanced degradation of β-catenin
Keywords: یوبی کوئیتینه شدن ; β-catenin; (-)-epigallocatechin-3 gallate; Head and cancer; Transactivation; Ubiquitination; P53; HNC; Head and neck cancer; EGCG; (-)-Epigallocatechin-3-gallate; TCF; T cell/lymphoid enhancer factor; DMEM; Dulbecco's modified Eagle's medium; MEM; Minimu
Jak-STAT3 pathway triggers DICER1 for proteasomal degradation by ubiquitin ligase complex of CUL4ADCAF1 to promote colon cancer development
Keywords: یوبی کوئیتینه شدن ; DICER1; CUL4ADCAF1 ligase complex; Jak-STAT3; Ubiquitination; Colon cancer; IL-6;
Ubiquitination-mediated degradation of cell cycle-related proteins by F-box proteins
Keywords: یوبی کوئیتینه شدن ; Cell cycle; F-box protein; Ubiquitination; UPS; Cancer; Degradation
RNF138 interacts with RAD51D and is required for DNA interstrand crosslink repair and maintaining chromosome integrity
Keywords: یوبی کوئیتینه شدن ; HR; homologous recombination; CFA; colony forming assay; NT; N-terminus; ssDNA; single-stranded DNA; ICL; interstrand crosslink; DSB; double-strand break; MEF; mouse embryo fibroblasts; MMC; mitomycin C; MMS; methyl methanesulfonate; PTM; post-translation
The E3 ubiquitin ligase CHIP mediates ubiquitination and proteasomal degradation of PRMT5
Keywords: یوبی کوئیتینه شدن ; PRMT5; protein arginine methyltransferase 5; EGFR; epidermal growth factor receptor; TNF; tumor necrosis factor; NF-Y; nuclear factor Y; PKC; protein kinase C; Hsp90; heat shock protein 90; UPS; ubiquitin-proteasome system; CHIP; carboxyl terminus of he
Identification of an adaptor protein that facilitates Nrf2-Keap1 complex formation and modulates antioxidant response
Keywords: یوبی کوئیتینه شدن ; Nrf2; Keap1; Antioxidant; Ubiquitination; PAQR3; Golgi apparatus;
The ubiquitin-proteasome system is essential for the productive entry of Japanese encephalitis virus
Keywords: یوبی کوئیتینه شدن ; Ubiquitin-proteasome system; Japanese encephalitis virus; Cellular trafficking; Productive entry; Lysosome; Ubiquitination;
Oligoubiquitination of tissue factor on Lys255 promotes Ser253-dephosphorylation and terminates TF release
Keywords: یوبی کوئیتینه شدن ; Tissue factor; Ubiquitination; Phosphorylation; Ubiquitin-conjugating enzymes; Protein phosphatase 2Â A; Microvesicles;
RNAi-mediated silencing of the Arabidopsis thaliana ULCS1 gene, encoding a WDR protein, results in cell wall modification impairment and plant infertility
Keywords: یوبی کوئیتینه شدن ; COP1; constitutive photomorphogenic 1; TRIP1; TGF-beta receptor interacting protein 1; FY; flowering time control protein FY; PRL1; protein pleiotropic regulatory locus 1; DCAF1; DDB1-CUL4 associated factor 1; MSI4; multicopy suppressor of IRA1 4; ASK1; A
Ubiquitin–Proteasome System in ABA Signaling: From Perception to Action
Keywords: یوبی کوئیتینه شدن ; ubiquitination; ABA signaling; ABA receptor; E3 ligase; protein post-translational modification; transcription factor
Pioglitazone inhibits EGFR/MDM2 signaling-mediated PPARγ degradation
Keywords: یوبی کوئیتینه شدن ; Pioglitazone; PPARγ; EGFR; Ubiquitination; Degradation;
The emerging role of deubiquitination in nucleotide excision repair
Keywords: یوبی کوئیتینه شدن ; UV; ultraviolet; NER; nucleotide excision repair; TC-NER; transcription coupled NER; GG-NER; global genome NER; XPC; xeroderma pigmentosum complementation group C; UV-DDB DUB; deubiquitinating enzyme; CS; cockayne syndrome; CSA; cockayne syndrome protein
Holding RIPK1 on the Ubiquitin Leash in TNFR1 Signaling
Keywords: یوبی کوئیتینه شدن ; RIPK1; necroptosis; TNFR1; LUBAC; cIAP1/2; ubiquitination
Perturbation of redox balance after thioredoxin reductase deficiency interrupts autophagy-lysosomal degradation pathway and enhances cell death in nutritionally stressed SH-SY5Y cells
Keywords: یوبی کوئیتینه شدن ; 3-MA; 3-Methyl adenine; AL; autolysosome; AP; autophagosome; ATG; autophagy related; Au; auranofin; Baf A1; bafilomycin A1; CCK-8; cell counting kit-8; CQ; chloroquine; DMEM; Dulbecco's modified eagle medium; DMSO; dimethyl sulfoxide; DTNB; 5,5'-Dithi
Ubiquitin ligase Fbw7 restricts the replication of hepatitis C virus by targeting NS5B for ubiquitination and degradation
Keywords: یوبی کوئیتینه شدن ; Fbw7; NS5B; Ubiquitination; Degradation; HCV replication;
Interleukin 1β Mediates Intestinal Inflammation in Mice and Patients With Interleukin 10 Receptor Deficiency
Keywords: یوبی کوئیتینه شدن ; VEOIBD; Treg Cell; Ubiquitination; Caspase-1; ATP; adenosine triphosphate; IL; interleukin; IL10R; interleukin 10 receptor; LPS; lipopolysaccharide; WT; wild-type;
Serum starvation induces anti-apoptotic cIAP1 to promote mitophagy through ubiquitination
Keywords: یوبی کوئیتینه شدن ; Serum starvation; Mitochondria; cIAP1; Mitophagy; Apoptosis; Ubiquitination;
Becoming a crossover-competent DSB
Keywords: یوبی کوئیتینه شدن ; Meiosis; Double-strand break; Crossover; Sumoylation; Ubiquitination;
Clomiphene citrate down-regulates estrogen receptor-α through the ubiquitin-proteasome pathway in a human endometrial cancer cell line
Keywords: یوبی کوئیتینه شدن ; Clomiphene citrate; Estrogen receptor-α; Endometrium; Ubiquitination; Proteasome;
cIAPs promote the proteasomal degradation of mutant SOD1 linked to familial amyotrophic lateral sclerosis
Keywords: یوبی کوئیتینه شدن ; FALS; SOD1; Ubiquitination; cIAPs;
TRAF2-mediated Lys63-linked ubiquitination of DUSP14/MKP6 is essential for its phosphatase activity
Keywords: یوبی کوئیتینه شدن ; DUSP14/MKP6; TRAF2; Ubiquitination; T-cell receptor signaling;
Regulation of peroxisomal matrix protein import by ubiquitination
Keywords: یوبی کوئیتینه شدن ; AAA; ATPase associated with diverse cellular activities; APEM9; aberrant peroxisome morphology 9; HECT; homologous to the E6-AP carboxyl-terminus; PTS; peroxisomal targeting sequence; RBR ligase; RING-between-RING ligase; RING; really interesting new gene
USP7 promotes cell proliferation through the stabilization of Ki-67 protein in non-small cell lung cancer cells
Keywords: یوبی کوئیتینه شدن ; USP7; Ki-67; Non-small cell lung cancer; Ubiquitination; Cell proliferation;
F-box protein interactions with the hallmark pathways in cancer
Keywords: یوبی کوئیتینه شدن ; Ubiquitination; F-box proteins; E3 ubiquitin ligases; Signalling; Cancer hallmarks;
New strategy for renal fibrosis: Targeting Smad3 proteins for ubiquitination and degradation
Keywords: یوبی کوئیتینه شدن ; Fibrosis; Ubiquitination; Proteolysis targeting chimeric molecules; Computer-aided drug design;
Characterization of the interaction between the dopamine D4 receptor, KLHL12 and β-arrestins
Keywords: یوبی کوئیتینه شدن ; GPCR; β-arrestin; KLHL12; ubiquitination; dopamine D4 receptor; β2AR; β2-adrenergic receptor; ADHD; attention deficit hyperactivity disorder; BTB; bric à brac 1, tramtrack, and broad-complex; co-IP; co-immunoprecipitation; CXCR4; C-X-C chemokine recep
Regulation of Mitofusin1 by Mahogunin Ring Finger-1 and the proteasome modulates mitochondrial fusion
Keywords: یوبی کوئیتینه شدن ; BN-PAGE; blue native polyacrlamide gel electrophoresis; CCCP; carbonyl cyanide m-chlorophenyl hydrazone; CM-H2DCFDA; chloromethyl derivative of 2â²,7â²-dichlorodihydrofluorescein diacetate; Drp1; dynamin related protein 1; DTT; 1,4-dithiothreitol; ER; e
NEDDylation promotes endothelial dysfunction: A role for HDAC2
Keywords: یوبی کوئیتینه شدن ; Vascular endothelium; Atherosclerosis; Endothelial dysfunction; Protein degradation; NEDDylation; Ubiquitination
Ubiquitination-dependent degradation of p73 by the mitochondrial E3 ubiquitin ligase Hades
Keywords: یوبی کوئیتینه شدن ; p73; Hades; RING-finger domain; Ubiquitination; Mitochondria;
A lysine-to-arginine mutation on NEDD8 markedly reduces the activity of cullin RING E3 ligase through the impairment of neddylation cascades
Keywords: یوبی کوئیتینه شدن ; NEDD8; Neddylation; Cullins; Cullin-RING E3 ligases; Ubiquitination
Alpha-synuclein negatively regulates Notch1 intracellular domain protein stability through promoting interaction with Fbw7
Keywords: یوبی کوئیتینه شدن ; Notch1-IC; Alpha-synuclein; Fbw7; Ubiquitination; Proteasome; Lysosome
Identification of substrates of F-box protein involved in methylmercury toxicity in yeast cells
Keywords: یوبی کوئیتینه شدن ; Methylmercury; Toxicity; F-box protein; Ubiquitination;
Ubiquitin E3 ligase UHRF1 regulates p53 ubiquitination and p53-dependent cell apoptosis in clear cell Renal Cell Carcinoma
Keywords: یوبی کوئیتینه شدن ; Ubiquitination; p53; Apoptosis; ccRCC;
VHL negatively regulates SARS coronavirus replication by modulating nsp16 ubiquitination and stability
Keywords: یوبی کوئیتینه شدن ; VHL; SARS-CoV; nsp16; Replication; Ubiquitination;
Precise protein post-translational modifications modulate ABI5 activity
Keywords: یوبی کوئیتینه شدن ; ABI5; ABA signaling; ubiquitination; sumoylation; (de-)phosphorylation
Error-free DNA-damage tolerance in Saccharomyces cerevisiae
Keywords: یوبی کوئیتینه شدن ; DNA-damage tolerance; Error-free bypass; PCNA; Ubiquitination; Sumoylation; Saccharomyces cerevisiae;
Determinants for degradation of SAMHD1, Mus81 and induction of G2 arrest in HIV-1 Vpr and SIVagm Vpr
Keywords: یوبی کوئیتینه شدن ; HIV-1; SIV; Vpr; Mus81; Agm; SAMHD1; DCAF1; G2 arrest; Ubiquitination; MLN4924;
The E3 ubiquitin ligase Itch and Yap1 have antagonistic roles in the regulation of ASPP2 protein stability
Keywords: یوبی کوئیتینه شدن ; Ubiquitination; Proteasomal degradation; WW domain; PPXY motif; Apoptosis
Chimeric ubiquitin ligases inhibit non-small cell lung cancer via negative modulation of EGFR signaling
Keywords: یوبی کوئیتینه شدن ; NSCLC; EGFR; Ubiquitination; Targeted therapy;