Keywords: حجم توزیع در حالت پایدار; Allometry; Antibody biodistribution coefficient; Monoclonal antibodies; Tissue-to-plasma partition coefficients; Volume of distribution at steady state;
مقالات ISI حجم توزیع در حالت پایدار (ترجمه نشده)
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Keywords: حجم توزیع در حالت پایدار; A to BA; pical to Basolateral; ANOVA; Analysis of variance; AUC; Area under the curve; B to A; Basolateral to Apical; BA; Bioavailability; CL; Clearance; CMC; Carboxymethyl cellulose; DMSO; Dimethyl sulfoxide; ER; Extraction ratio; FDA; Food and Drug Admi
Keywords: حجم توزیع در حالت پایدار; ABD3; albumin-binding domain 3; ACN; acetonitrile; AUC; area under the curve; BA; bioavailability; cAMP; cyclic adenosine monophosphate; CHO; Chinese hamster ovary; DIEA; diisopropyl ethylene diamine; Cmax; peak plasma concentration; CLp; plasma clearance
Keywords: حجم توزیع در حالت پایدار; preclinical pharmacokinetics; physiological model; simulations; clearance; absorption; distribution; ADAM; advanced dissolution absorption and metabolism; B:P; blood-to-plasma ratio; CLint; intrinsic clearance; CLiv; intravenous clearance; CLu,intH; unbou
Keywords: حجم توزیع در حالت پایدار; mAb; charge heterogeneity; C-terminal Lys deletion; Lys and Gly deletion; pharmacokinetics; bioavailability; ATA; anti-therapeutic antibody; CDC; complement-dependent cytotoxicity; CL; clearance; ELISA; enzyme-linked immunosorbent assay; Fab; fragment ant
Keywords: حجم توزیع در حالت پایدار; bioanalysis; disposition; elimination; HPLC; metabolite kinetics; pharmacokinetics; prodrugs; AUC0ââ; area under the plasma drug concentration-time profile from zero to infinity; Cltot; total clearance; Cmax; maximal concentration of a drug in plasm
Safety, immunogenicity, and clinical outcomes in patients with Morquio A syndrome participating in 2 sequential open-label studies of elosulfase alfa enzyme replacement therapy (MOR-002/MOR-100), representing 5â¯years of treatment
Keywords: حجم توزیع در حالت پایدار; Morquio A; Mucopolysaccharidosis IVA; Long-term extension; Elosulfase alfa; 3MSCT; 3-min stair climb test; 6MWT; 6-min walk test; AE; adverse event; AUC0ât; area under the curve from time 0 to last measurable concentration; AUCinf; area under the curve
Synthesis and profiling of benzylmorpholine 1,2,4,5-tetraoxane analogue N205: Towards tetraoxane scaffolds with potential for single dose cure of malaria
Keywords: حجم توزیع در حالت پایدار; AUC; area under the curve; BA; bioavailability; CLplasma; plasma clearance; CLint; intrinsic clearance; CYP; cytochrome P450; DCM; dichloromethane; DMF; dimethyl formamide; ED; effective dose; FaSSIF; fasted state simulated intestinal fluid; FeSSIF; fed s
In Vitro-In Vivo Evaluation of an Oral Ghost Drug Delivery Device for the Delivery of Salmon Calcitonin
Keywords: حجم توزیع در حالت پایدار; oral absorption; peptide delivery; pharamcokinetics; proteins; drug transport; polymer synthesis; OGDD; Oral Ghost Drug Delivery; UHMW-PE; ultra-high-molecular-weight polyethylene; AAm; polyethylene: acrylamide monomers; MAA; methyacrylic acid; BIS; N-N
Individual serum bile acid profiling in rats aids in human risk assessment of drug-induced liver injury due to BSEP inhibition
Keywords: حجم توزیع در حالت پایدار; ALT; alanine amino transferase; AST; aspartate amino transferase; AUClast; area under the plasma time curve from time 0 to the last measured concentration (24Â h); BSEP; Bile Salt Export Pump; CL; clearance; C0; highest initial plasma concentration of dru
Role of efflux transporters in the absorption, distribution and elimination in rodents of a novel PDE4 inhibitor, CHF6001
Keywords: حجم توزیع در حالت پایدار; ADME; absorption, distribution, metabolism and excretion; AUC0-t(last); area under the concentration-time curve up to the last measurable concentration; AUCinf; area under the concentration-time curve up to infinity; AUCÏ; area under the concentration-ti
A PEGylated analog of short-length Neuromedin U with potent anorectic and anti-obesity effects
Keywords: حجم توزیع در حالت پایدار; Neuromedin U (NMU); NMU-8; Polyethylene glycol (PEG); Diabetes; Obesity; NMU; neuromedin U; PEG; polyethyleneglycol; PipAc; 2-(piperazin-1-yl)acetic acid; CNS; central nervous system; DIO; diet-induced obesity; EMCS; N-(6-maleimidocaproyloxy)succinimide;
Structure-based design of a new series of N-(piperidin-3-yl)pyrimidine-5-carboxamides as renin inhibitors
Keywords: حجم توزیع در حالت پایدار; AcOH; acetic acid; Ang I; angiotensin I; Ang II; angiotensin II; AUC; area under the blood concentration-time curve; C5min; concentration in plasma 5Â min after administration; CLtotal; total clearance; Cmax; maximum concentration in plasma; DIEA; N,N-d
Preclinical pharmacokinetic and toxicological evaluation of MIF-1 peptidomimetic, PAOPA: Examining the pharmacology of a selective dopamine D2 receptor allosteric modulator for the treatment of schizophrenia
Keywords: حجم توزیع در حالت پایدار; 5-HT2; 5-hydroxytryptamine; 6-OHDA; 6-hydroxydopamine; AM; allosteric modulator; AUC; area under curve; AUCINF; area under curve extrapolated to infinity; AUClast; area under curve from dosing to observation; AUMC; area under first moment curve; CL; total
Hemolytic and pharmacokinetic studies of liposomal and particulate amphotericin B formulations
Keywords: حجم توزیع در حالت پایدار; AmB; Amphotericin B; RBCs; red blood cells; RES; reticulo-endothelial system; FD; non-microencapsulated free dimeric AmB formulation; F; Fungizone®; HF; heated-Fungizone; MD; microencapsulated dimer AmB; FP; non-microencapsulated free poly-aggregated AmB
Immunopharmacotherapeutic manifolds and modulation of cocaine overdose
Keywords: حجم توزیع در حالت پایدار; mAb; monoclonal antibody; IgG; immunoglobulin G; Fab; Fab antibody fragment; scFv; single-chain antibody fragment; VH and VL; antibody heavy- and light-chain variable domains; GNC-BSA; GNC hapten conjugated to bovine serum albumin carrier protein; i.v.;
Cassette Dosing for Pharmacokinetic Screening in Drug Discovery: Comparison of Clearance, Volume of Distribution, Half-Life, Mean Residence Time, and Oral Bioavailability Obtained by Cassette and Discrete Dosing in Rats
Keywords: حجم توزیع در حالت پایدار; clearance; cassette dosing; N-in-one dosing; pharmacokinetics; drug discovery; volume of distribution at steady state; half-life; oral bioavailability; liquid chromatography—tandem mass spectrometry
PhRMA CPCDC initiative on predictive models of human pharmacokinetics, part 2: Comparative assessment of prediction methods of human volume of distribution
Keywords: حجم توزیع در حالت پایدار; volume of distribution at steady state; pharmacokinetics; protein binding; computational ADME; first-time-in-human; in vitro models; distribution; allometry;