Binding of coronin 1B to TβRI negatively regulates the TGFβ1 signaling pathway
Keywords: Coronin 1B; TGFβ1; TβRI; VSMCs;
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Cellular subtype expression and activation of CaMKII regulate the fate of atherosclerotic plaque
Keywords: Atherosclerosis; CaMKII; VSMCs; Macrophages; Stable plaques; Unstable plaques;
Roscovitine attenuates intimal hyperplasia via inhibiting NF-κB and STAT3 activation induced by TNF-α in vascular smooth muscle cells
Keywords: VSMCs; vascular smooth muscle cells; TNF-α; tumor necrosis factor α; MAPKs; mitogen-activated protein kinases; NF-κB; nuclear factor-kappa B; JAK-STAT; Janus kinase-signal transducer and activator of transcription; IL-1β; interleukin-lβ; MCP-1; monoc
TNAP stimulates vascular smooth muscle cell trans-differentiation into chondrocytes through calcium deposition and BMP-2 activation: Possible implication in atherosclerotic plaque stability
Keywords: Tissue-nonspecific alkaline phosphatase; Microcalcification; Inorganic pyrophosphate; Vascular calcification; VSMCs; Chondrocytes;
Redox regulation of the actin cytoskeleton and its role in the vascular system
Keywords: α; alpha; β; beta; γ; gamma; G-actin; globular actin; F-actin; filamentous actin; ROS; reactive oxygen species; O2â¢â; superoxide; H2O2; hydrogen peroxide; HOâ¢; hydroxyl radical; RNS; reactive nitrogen species; NO; nitric oxide; â¢NO2; nitrogen d
Terlipressin, a vasoactive prodrug recommended in hepatorenal syndrome, is an agonist of human V1, V2 and V1B receptors: Implications for its safety profile
Keywords: Terlipressin, PubChem CID: 72081; [Arginine8]Vasopressin, PubChem CID: 90488786; [Lysine8]Vasopressin, PubChem CID: 90488785; SR49059, PubChem CID: 60943; AVP; [arginine8]vasopressin; LVP; [lysine8]vasopressin; HRS; hepatorenal syndrome; VSMCs; vascular s
Selection of a high-affinity and in vivo bioactive ssDNA aptamer against angiotensin II peptide
Keywords: Angiotensin II; Aptamer; SELEX; Serum electrolytes; VSMCs; Urine volume
Upregulation of MKP-7 in response to rosiglitazone treatment ameliorates lipopolysaccharide-induced destabilization of SIRT1 by inactivating JNK
Keywords: SIRT1; silent mating type information regulation 2 homolog 1; PPARγ; peroxisome proliferator-activated receptor γ; LPS; lipopolysaccharide; MKP-7; mitogen-activated protein kinase phosphatase-7; PGC-1α; peroxisome proliferator-activated receptor gamma
LMNA mutations resulting in lipodystrophy and HIV protease inhibitors trigger vascular smooth muscle cell senescence and calcification: Role of ZMPSTE24 downregulation
Keywords: Vascular smooth muscle cells; ZMPSTE24; Prelamin A; Senescence; Osteogenic transdifferentiation; Atherosclerosis; ALP; alkaline phosphatase; ATV; atazanavir; DRV; darunavir; HIV; human immunodeficiency virus; LPV; lopinavir; M/R; maraviroc/raltegravir; PB
WNT/β-catenin signaling promotes VSMCs to osteogenic transdifferentiation and calcification through directly modulating Runx2 gene expression
Keywords: VSMCs; vascular smooth muscle cells; AMC; arterial medial calcification; β-GP; β-glycerophosphoricacid; LRP; low density lipoprotein receptor-related protein; GSK; glycogen synthase kinase; PORCN; Porcupine; WNT/β-catenin signaling; Runx2; Vascular smo
Polymerase delta-interacting protein 2 regulates collagen accumulation via activation of the Akt/mTOR pathway in vascular smooth muscle cells
Keywords: Akt; protein kinase B; Atg; autophagy-related gene; ECM; extracellular matrix; 4E-BP1; eukaryotic initiation factor 4E binding protein 1; eIF4E; eukaryotic translation initiation factor 4E; Hsc70; heat shock cognate protein 70; LC3B; microtubule-associate
Equol increases cerebral blood flow in rats via activation of large-conductance Ca2+-activated K+ channels in vascular smooth muscle cells
Keywords: ACh; acetylcholine; 4-AP; 4-aminopyridine; ANOVA; analysis of variance; BaCl2; barium chloride; BK; large-conductance, voltage- and Ca2+ -activated K+ channel; BSA; bovine serum albumin; CASMCs; cerebral artery smooth muscle cells; DBP; diastolic blood pr
Endothelial progenitor cells induce transplant arteriosclerosis via VEGFR-1/2 activity
Keywords: Endothelial progenitor cells; Transplant arteriosclerosis; VEGFR-1/2; AR; acute rejection; Akt; protein kinase B; CAV; cardiac allograft vasculopathy; CD31; cluster of differentiation 31; CM-Dil; chlormethyl-benzamidodialkylcarbocyanine; DiI-ac-LDL; DiI-l
Advanced glycation end products accelerate arteriosclerosis after renal transplantation through the AGE/RAGE/ILK pathway
Keywords: AGEs; Kidney transplantation; Arteriosclerosis; VSMCs; Osteoblast; Trans-differentiation; RAGE; ILK
Epoxyeicosatrienoic acids act through TRPV4-TRPC1-KCa1.1 complex to induce smooth muscle membrane hyperpolarization and relaxation in human internal mammary arteries
Keywords: LIMAs; human left internal mammary arteries; EETs; epoxyeicosatrienoic acids; 11,12-EET; 11,12-epoxyeicosatrienoic acid; KCa1.1; large conductance Ca2Â +-activated K+ channels; TRPV4; vanilloid transient receptor potential channel 4; TRPC1; canonical tran
Noncoding RNAs as regulators of cardiomyocyte proliferation and death
Keywords: miRNAs; microRNAs; lncRNA; long non-coding RNA; LAD; left anterior descending coronary artery; hCMPCs; human Cardiomyocyte Progenitor Cells; CSCs; Cardiac Stem Cells; MI; Myocardial Infarction; MFN1; Mitofusin 1; I/R; Ischemia/Reperfusion; BNIP3; BCL2/ade
Metabolomic analysis revealed the role of DNA methylation in the balance of arachidonic acid metabolism and endothelial activation
Keywords: AA; arachidonic acid; COX; cyclooxygenases; LOX; lipoxygenases; CYP; cytochrome P450; EETs; epoxyeicosatrienoic acids; HETEs; hydroxyeicosatetraenoic acids; PGs; prostaglandins; PGD2; prostaglandin D2; PTGDS; prostaglandin D2 synthase; TXB2; thromboxane B
Salusin-β contributes to vascular remodeling associated with hypertension via promoting vascular smooth muscle cell proliferation and vascular fibrosis
Keywords: AC; adenylate cyclase; ALK5; activin receptor-like kinase 5; Ang II; angiotensin II; CCK-8; cell counting kit-8 kits; CREB; cAMP response element binding protein; CTGF; connective tissue growth factor; ECM; extracellular matrix; EGF; epidermal growth fact
Mouse model of CADASIL reveals novel insights into Notch3 function in adult hippocampal neurogenesis
Keywords: BrdU; bromodeoxyuridine; CADASIL; cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy; E; embryonic day; DG; dentate gyrus; DCX; doublecortin; GFAP; glial fibrillaric acid protein; GOM; granular osmiophilic material;
Curcumin induces oxidation-dependent cell cycle arrest mediated by SIRT7 inhibition of rDNA transcription in human aortic smooth muscle cells
Keywords: VSMCs; Curcumin; Nucleolus; rDNA; SIRT7; DNMT2
miR-200c-SUMOylated KLF4 feedback loop acts as a switch in transcriptional programs that control VSMC proliferation
Keywords: ATRA; all-trans retinoic acid; cdk2; cyclin-dependent kinase 2; HASMC; human aortic smooth muscle cell; HDAC2; histone deacetylase 2; KLF; Krüppel-like factor; LSD1; lysine-specific demethylase 1; miR; microRNA; NCoR; nuclear receptor corepressor; p21; p
Apelin/APJ signaling in hypoxia-related diseases
Keywords: HIF-1α; hypoxia-inducible factor-1 alpha; Ang-II; angiotensin-II; HREs; hypoxia-responsive elements; PHD; prolyl hydroxylase; CoCl2; cobalt chloride; H/R; hypoxia/re-oxygenation; HIFP4H-2; hypoxia-inducible factor prolyl 4-hydroxylase 2; H/I; hypoxic/isc
Medicinal uses, phytochemistry and pharmacology of the genus Uncaria
Keywords: U1; Uncaria acida (Hunter) Roxb; U2; Uncaria africana G. Don; U3; Uncaria attenuate Korth; U4; Uncaria barbata Merr; U5; Uncaria bernaysii F. Muell; U6; Uncaria borneensis Havil; U7; Uncaria callophylla Blume ex Korth; U8; Uncaria canescens Korth; U9; Unc
A common variant in pre-miR-146 is associated with coronary artery disease risk and its mature miRNA expression
Keywords: SNP; single nucleotide polymorphism; miRNA; microRNA; CAD; coronary artery disease; PCR-RFLP; polymerase chain reaction-based restriction fragment length polymorphism; OR; odds ratio; CI; confidence interval; PBMCs; peripheral blood mononuclear cells; TC;
TRPC6 participates in the regulation of cytosolic basal calcium concentration in murine resting platelets
Keywords: Non-IP; non-immunoprecipitated fraction; IP; immunoprecipitated fraction; input; unbiotinylated fraction; VSMCs; mesenteric artery vascular smooth muscle cells; TRPC; Calcium; Platelets; Hemostasis; Thrombosis;
Hesperetin inhibits rat coronary constriction by inhibiting Ca2+ influx and enhancing voltage-gated K+ channel currents of the myocytes
Keywords: Hesperetin: PubChem CID 72281; 9,11-Dideoxy-9a,11a- methanoepoxy prostaglandin F2α (U46619): PubChem CID 5311493; S-(â)-1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-3-pyridinecarboxylic acid methyl ester (Bay K 8644): PubChem CID 2303
Crystal structure of phospholipase PA2-Vb, a protease-activated receptor agonist from the Trimeresurus stejnegeri snake venom
Keywords: PLA2; phospholipases A2; PAR-1; protease-activated receptor 1; IP3R; inositol 1,4,5-trisphosphate receptor; svPLA2; snake venom PLA2; VSMCs; vascular smooth muscle cells; SR; sarcoplasmic reticulum; RyR; ryanodine receptor; GPCRs; G-protein coupled recept
GSTpi protects against angiotensin II-induced proliferation and migration of vascular smooth muscle cells by preventing signal transducer and activator of transcription 3 activation
Keywords: Ang II; angiotensin II; VSMCs; vascular smooth muscle cells; GSTpi; glutathione S-transferase pi; STAT3; signal transducer and activator of transcription 3; GSH; glutathione; TNF-α; tumor necrosis factor alpha; JNK; c-Jun NH2-terminal kinases; TRAF2; tum
FAM3A promotes vascular smooth muscle cell proliferation and migration and exacerbates neointima formation in rat artery after balloon injury
Keywords: FAM3A; VSMCs; Proliferation; P2Y receptor; EP2;
Visfatin contributes to the differentiation of monocytes into macrophages through the differential regulation of inflammatory cytokines in THP-1 cells
Keywords: DeM; differentiated macrophages; DiM; differentiating macrophages; ERK; extracellular signal-regulated kinase; FACS; fluorescence-activated cell sorter; FBS; fetal bovine serum; HRP; horseradish peroxidase; iNOS; inducible nitric oxide synthase; IL-1Ra; I
A century old renin-angiotensin system still grows with endless possibilities: AT1 receptor signaling cascades in cardiovascular physiopathology
Keywords: RAS; renin-angiotensin system; AOG; angiotensinogen; Ang II; angiotensin II; ACE; angiotensin converting enzyme; ARBs; angiotensin AT1 receptor blockers; Mas R; Mas receptor; TGF-β; transforming growth factor-β; Ang A; angiotensin A; eNOS; endothelial
miR-125b/Ets1 axis regulates transdifferentiation and calcification of vascular smooth muscle cells in a high-phosphate environment
Keywords: VSMCs; vascular smooth muscle cells; β-GP; β-glycerophosphoric acid; miR-125b; VSMCs; Calcification;
Transglutaminase 2 as a novel activator of LRP6/β-catenin signaling
Keywords: Fzd; Frizzled; LRP5/6; LRP5 or LRP6; APC; Adenomatosis Polyposis Coli; GSK3; Glycogen Synthase Kinase 3; TG2; Tissue transglutaminase; VSMCs; Vascular smooth muscle cells; TGases; Transglutaminases; ECM; Extracellular matrix; MEFs; Mouse embryonic fibrobl
Nalp3 inflammasome is activated and required for vascular smooth muscle cell calcification
Keywords: β-GP; β-glycerophosphate; VSMCs; vascular smooth muscle cells; Nalp3 inflammasomes; VSMC calcification; IL-1β secretion;
Intravenous release of NO from lipidic microbubbles accelerates deep vein thrombosis resolution in a rat model
Keywords: DVT; deep vein thrombosis; PE; pulmonary embolism; LMWH; low molecular weight heparin; NO; nitric oxide; VSMCs; vascular smooth muscle cells; FDA; Food and Drug Administration; IVC; inferior vena cava; LCIV; left common iliac vein; DPPE-PEG2k; 1, 2-Dipa
Brg1-dependent epigenetic control of vascular smooth muscle cell proliferation by hydrogen sulfide
Keywords: VSMCs; vascular smooth muscle cells; H2S; hydrogen sulfide; CSE; cystathionine γ-lyase; CBS; cystathionine β-synthase; MAPK; mitogen-activated protein kinase; Brg1; Brahma-related gene 1; Brm; Brahma; RNAi; RNA interference; RASMCs; rat aortic smooth mu
Aging decreases the contribution of MaxiK channel in regulating vascular tone in mesenteric artery by unparallel downregulation of α- and β1-subunit expression
Keywords: BP; blood pressure; BW; body weight; CVDs; cardiovascular diseases; [Ca2+]i; intracellular Ca2+ concentration; DBP; diastolic blood pressure; G; conductance; HR; heart rate; HP; holding potential; HW; heart weight; IbTX; iberiotoxin; MaxiK (or BKCa); larg
Plasmacytoid dendritic cells: Biomarkers or potential therapeutic targets in atherosclerosis?
Keywords: Atherosclerosis; Plasmacytoid dendritic cells; Interferons; Autoimmunity; AMI; Acute myocardial infarction; ACPA; anti-citrullinated protein antibodies; APC; antigen presenting cells; apoE; apolipoprotein-E; BDCA; blood dendritic cell antigen; BST-2; bone
Chitinase 3-like 1 gene-329G/A polymorphism, plasma concentration and risk of coronary heart disease in a Chinese population
Keywords: AMI; acute myocardial infarction; BMI; body mass index; CAG; coronary angiography; CHD; coronary heart disease; CVD; cardiovascular disease; FBS; fasting blood sugar; HDL-C; high-density lipoprotein cholesterol; LDL-C; low-density lipoprotein cholesterol;
Signalling from dead cells drives inflammation and vessel remodelling
Keywords: VSMCs; Vascular smooth muscle cells; IL-1; interleukin-1; MCP-1; monocyte chemoattractant protein 1; TRAIL; Tumour necrosis factor-related apoptosis inducing ligand; TNF; Tumour necrosis factor; IFN; interferon; ECM; extracellular matrix; eNOS; endothelia
Clitocybin B inhibits rat aortic smooth muscle cell proliferation through suppressing PDGF-Rβ phosphorylation
Keywords: CDK; cyclin-dependent kinase; DMEM; Dulbecco's Modified Eagle's Media; DMSO; dimethyl sulfoxide; ERK; extracellular signal regulated kinase; FBS; fetal bovine serum; HEPES; N-[2-hydroxyethyl]piperazine-N-[2-ethanesulfonic acid]; MAPK; mitogen-activated pr
Downregulation of miR-223 and miR-153 mediates mechanical stretch-stimulated proliferation of venous smooth muscle cells via activation of the insulin-like growth factor-1 receptor
Keywords: Vascular smooth muscle cells; VSMCs; Insulin-like growth factor-1 receptor; IGF-1R; MiR-223; MiR-153; PI3K-AKT pathway;
Regulation of S100A4 expression via the JAK2-STAT3 pathway in rhomboid-phenotype pulmonary arterial smooth muscle cells exposure to hypoxia
Keywords: JAKs; Janus kinases; STATs; signal transducers and activators of transcription; HIF-1; hypoxia induced factor 1; PASMCs; pulmonary arterial smooth muscle cells; VSMCs; vascular smooth muscle cells; R-SMCs; rhomboid VSMCs; S-SMCs; spindle-shaped SMCs; PAH;
Ethanol induces vascular relaxation via redox-sensitive and nitric oxide-dependent pathways
Keywords: NO; Nitric oxide; eNOS; endothelial NO synthase; nNOS; neuronal NO synthase; ROS; reactive oxygen species; ([Ca2Â +]c); Cytosolic calcium concentration; ADH; alcohol dehydrogenase; ([NO]c); Cytosolic NO concentration; VSMCs; vascular smooth muscle cells;
Anti-atherosclerotic action of Ger-Gen-Chyn-Lian-Tang and AMPK-dependent lipid lowering effect in hepatocytes
Keywords: AMPK; AMP-activated protein kinase; ACC; acetyl-CoA carboxylase; BMDM; bone marrow-derived macrophages; FAS; fatty acid synthase; FG; fasting glucose; GGCLT; Ger-Gen-Chyn-Lian-Tang; HCD; high cholesterol diet; HDL; high-density lipoprotein; LDL; low-densi
Anti-proliferative actions of 2-decylamino-5,8-dimethoxy-1,4-naphthoquinone in vascular smooth muscle cells
Keywords: 2-decylamino-DMNQ; 2-decylamino-5,8-dimethoxy-1,4-naphthoquinone; VSMCs; vascular smooth muscle cells; PDGF; platelet-derived growth factor; Erk1/2; extracellular regulated kinases 1/2; PLCγ; phospholipase γ; PDGF-Rβ; PDGF receptor β; CDK; cyclin-depe
AMPK induces vascular smooth muscle cell senescence via LKB1 dependent pathway
Keywords: Senescence; VSMCs; Proliferation; AMPK; LKB1
Insulin-mediated upregulation of KCa3.1 channels promotes cell migration and proliferation in rat vascular smooth muscle
Keywords: Intermediate-conductance Ca2+ activated K+ channel; Insulin; VSMCs; ERK1/2; Migration; Proliferation
Resolvins: Natural agonists for resolution of pulmonary inflammation
Keywords: Catabasis; Lipid mediators; Lung; Neutrophils; Omega-3; Polyunsaturated fatty acids; AA; arachidonic acid; ALI; acid lung injury; ALX/FPR2; lipoxin A4 receptor/formyl peptide receptor 2; ARDS; acute respiratory distress syndrome; ATL; aspirin-triggered li
Rosiglitazone induces the unfolded protein response, but has no significant effect on cell viability, in monocytic and vascular smooth muscle cells
Keywords: Rosiglitazone; ER stress; Unfolded protein response; SERCA2b; Type 2 diabetes; Monocytes; VSMCs