کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10027723 | 1591912 | 2005 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Heterogeneous susceptibility to metronidazole and clarithromycin of Helicobacter pylori isolates from a single biopsy in adults is confirmed in children
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
میکروبیولوژی و بیوتکنولوژی کاربردی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Heterogeneous susceptibility to metronidazole and clarithromycin of Helicobacter pylori isolates from a single biopsy in adults is confirmed in children Heterogeneous susceptibility to metronidazole and clarithromycin of Helicobacter pylori isolates from a single biopsy in adults is confirmed in children](/preview/png/10027723.png)
چکیده انگلیسی
The aim of this study was to assess the resistance to metronidazole and clarithromycin of individual colonies of Helicobacter pylori from a single biopsy taken from 14 adults and 14 children. The Etest was used to determine the minimum inhibitory concentrations (MICs) of these two antimicrobial drugs for ten individual H. pylori colonies isolated from each initial gastric biopsy culture. We confirmed the heterogeneity in metronidazole and clarithromycin resistance in children as seen in adults before anti-H. pylori treatment. The number of resistant individual colonies ranged from two to nine depending on the subject. All individual colonies from the same biopsy that were resistant to clarithromycin were genetically identical according to randomly amplified polymorphic DNA testing and exhibited the same point mutation according to polymerase chain reaction-restriction fragment length polymorphism.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Antimicrobial Agents - Volume 26, Issue 4, October 2005, Pages 272-278
Journal: International Journal of Antimicrobial Agents - Volume 26, Issue 4, October 2005, Pages 272-278
نویسندگان
Josette Raymond, Bang Nguyen, Michel Bergeret, Christophe Dupont, Nicolas Kalach,