کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10106890 | 1613215 | 2018 | 24 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Zebrafish models of epigenetic regulation of CNS functions
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
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چکیده انگلیسی
Epigenetic regulation has become a key focus of neuroscience and biopsychiatry, implicating DNA methylation, histone modification and other epigenetic mechanisms in various CNS disorders. Animal (experimental) models are a useful tool for epigenetic studies. Although most such research has been performed in rodents, the zebrafish (Danio rerio) is rapidly emerging as a new promising model organism in neuroscience. These fish are particularly suitable for genetic and epigenetic studies due to their fully sequenced genome, easiness of genetic analyses and high physiological and genetic homology with humans. Here, we discuss mounting evidence of epigenetic regulation of CNS functions in zebrafish, and outline future directions of translational research in this field.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research Bulletin - Volume 142, September 2018, Pages 344-351
Journal: Brain Research Bulletin - Volume 142, September 2018, Pages 344-351
نویسندگان
Anton M. Lakstygal, Murilo S. de Abreu, Allan V. Kalueff,