Helioscopianoids A-Q, bioactive jatrophane diterpenoid esters from Euphorbia helioscopia

Seventeen new jatrophane diterpenoid esters, helioscopianoids A-Q (117), were isolated from the whole plants of Euphorbia helioscopia. Compounds 8 and 16 showed P-glycoprotein inhibitory activities, and compounds 2, 8, and 12 showed neuroprotective activities.281