کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10159001 | 34 | 2014 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Alleviation of capsular formations on silicone implants in rats using biomembrane-mimicking coatings
ترجمه فارسی عنوان
کاهش ترکیبات کپسولی بر روی ایمپلنت های سیلیکون در موش های صحرایی با استفاده از پوشش های بیوموژن
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کلمات کلیدی
واکنش بدن خارجی، سیلیکون، اصلاح سطح، فسفوریل کلین، انقباض کپسول،
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
بیو مهندسی (مهندسی زیستی)
چکیده انگلیسی
Despite their popular use in breast augmentation and reconstruction surgeries, the limited biocompatibility of silicone implants can induce severe side effects, including capsular contracture - an excessive foreign body reaction that forms a tight and hard fibrous capsule around the implant. This study examines the effects of using biomembrane-mimicking surface coatings to prevent capsular formations on silicone implants. The covalently attached biomembrane-mimicking polymer, poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC), prevented nonspecific protein adsorption and fibroblast adhesion on the silicone surface. More importantly, in vivo capsule formations around PMPC-grafted silicone implants in rats were significantly thinner and exhibited lower collagen densities and more regular collagen alignments than bare silicone implants. The observed decrease in α-smooth muscle actin also supported the alleviation of capsular formations by the biomembrane-mimicking coating. Decreases in inflammation-related cells, myeloperoxidase and transforming growth factor-β resulted in reduced inflammation in the capsular tissue. The biomembrane-mimicking coatings used on these silicone implants demonstrate great potential for preventing capsular contracture and developing biocompatible materials for various biomedical applications.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Acta Biomaterialia - Volume 10, Issue 10, October 2014, Pages 4217-4225
Journal: Acta Biomaterialia - Volume 10, Issue 10, October 2014, Pages 4217-4225
نویسندگان
Ji Ung Park, Jiyeon Ham, Sukwha Kim, Ji-Hun Seo, Sang-Hyon Kim, Seonju Lee, Hye Jeong Min, Sunghyun Choi, Ra Mi Choi, Heejin Kim, Sohee Oh, Ji An Hur, Tae Hyun Choi, Yan Lee,