کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10159481 49 2013 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Dissolving polymer microneedle patches for rapid and efficient transdermal delivery of insulin to diabetic rats
ترجمه فارسی عنوان
تکه های میکروسکوپ پلیمری تجزیه شده برای تحویل سریع و موثر انسولین به موش های دیابتی
کلمات کلیدی
قابلیت دسترسی بیولوژیک، آزادی بولوس، اثر هیپوگلیسمی، پلی ساکارید، تحویل پروتئین،
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی بیو مهندسی (مهندسی زیستی)
چکیده انگلیسی
This study presents a dissolving microneedle patch, composed of starch and gelatin, for the rapid and efficient transdermal delivery of insulin. The microneedles completely dissolve after insertion into the skin for 5 min, quickly releasing their encapsulated payload into the skin. A histological examination shows that the microneedles have sufficient mechanical strength to be inserted in vitro into porcine skin to a depth of approximately 200 μm and in vivo into rat skin to 200-250 μm depth. This penetration depth does not induce notable skin irritation or pain sensation. To evaluate the feasibility of using these dissolving microneedles for diabetes treatment insulin-loaded microneedles were administered to diabetic rats using a homemade applicator. Pharmacodynamic and pharmacokinetic results show a similar hypoglycemic effect in rats receiving insulin-loaded microneedles and a subcutaneous injection of insulin. The relative pharmacological availability and relative bioavailability of insulin were both approximately 92%, demonstrating that insulin retains its pharmacological activity after encapsulation and release from the microneedles. Storage stability analysis confirms that more than 90% of the insulin remained in the microneedles even after storage at 25 or 37 °C for 1 month. These results confirm that the proposed starch/gelatin microneedles enable stable encapsulation of bioactive molecules and have great potential for transdermal delivery of protein drugs in a relatively painless, rapid, and convenient manner.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Acta Biomaterialia - Volume 9, Issue 11, November 2013, Pages 8952-8961
نویسندگان
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