Effect of strontium-substituted biphasic calcium phosphate on inflammatory mediators production by human monocytes

In contact or when engulfed by monocytes wear debris () induce a production of several mediators including pro-inflammatory (TNF-α, IL-1β, IL-6 and IL-18), chemotactic (IL-8) and anti-inflammatory (IL-10) ones. All these factors act in balance with each other and with proteases (MMP-9 ) and their inhibitors (TIMP-1 ) to ensure tissue homeostasis and renewal (ie. osteoclastogenesis). The use of strontium-substituted BCP () can decrease the production of inflammatory cytokines (TNF-α and IL-6), chemokine (IL-8) and proteases inhibitor (TIMP-1). This allows a fine tuning of inflammatory response which cannot be exacerbated due to maintained IL-10 concentration. Moreover, BCP5% favors matrix turnover by decreased TIMP-1 and increased MMP-9 production.