Poly(amidoamine) dendrimer-grafted porous hollow silica nanoparticles for enhanced intracellular photodynamic therapy

A new drug vehicle for photodynamic therapy drug delivery was developed by grafting third-generation (G3) polyamidoamine (PAMAM) to the surface of porous hollow silica nanoparticles (PHSNPs) , followed by the attachment of gluconic acid (GA) as surface charge tuning. Such fabricated hybrid material exhibited high loading efficacy of aluminum phthalocyanine tetrasulfonate (AlPcS4), allowing generating reactive singlet oxygen by photoactivation to efficiently incapacitate tumor cells.