کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10160249 73 2011 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Biodegradable functional poly(ester amide)s with pendant hydroxyl functional groups: Synthesis, characterization, fabrication and in vitro cellular response
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی بیو مهندسی (مهندسی زیستی)
پیش نمایش صفحه اول مقاله
Biodegradable functional poly(ester amide)s with pendant hydroxyl functional groups: Synthesis, characterization, fabrication and in vitro cellular response
چکیده انگلیسی
The synthesis of a new family of biodegradable α-amino acid poly(ester amide)s (AA-PEAs) with pendant benzyl ether groups and hydroxyl functional groups is reported. The synthetic strategy employs the ring opening reaction of O-benzyl-l-serine-N-carboxyanhydride with di-p-toluenesulfonic acid salts of bis-l-valine butane-1,4-diester, followed by solution polycondesation reactions with di-p-nitrophenyl sebacate in N,N-dimethylacetamide. Catalytic hydrogenation of the resulting benzyl ether protected AA-PEAs (PEA-Ser-Bzs) was performed to restore the hydroxyl functional groups in the functionalized AA-PEAs (PEA-Ser-OH). All resulting polymers were characterized by standard physico-chemical methods. The pendant hydroxyl groups in PEA-Ser-OH were used to fabricate AA-PEA-based gels via acrylation and photo-gelation. The cell-polymer interactions of PEA-Ser-Bz and PEA-Ser-OH were evaluated in terms of cell attachment and proliferation assay using bovine aortic endothelial cells (BAECs) as well as fibroblasts. The cell culture data indicated that the hydrophobic/hydrophilic characteristics (from contact angle data) of these AA-PEAs could significantly affect the interaction between BAECs and AA-PEA. This finding may provide additional possible applications for this new family of functionalized AA-PEA polymers.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Acta Biomaterialia - Volume 7, Issue 4, April 2011, Pages 1504-1515
نویسندگان
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