کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10160673 | 252 | 2005 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Operational stability of subtilisin CLECs in organic solvents in repeated batch and in continuous operation
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
بیو مهندسی (مهندسی زیستی)
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چکیده انگلیسی
The operational stability of cross-linked crystals (CLECs) of subtilisin Carlsberg in organic media is compared between repeated batch and continuous flow operation. The study was designed to create similar conditions in the two modes, although these can never be identical in all respects. The biocatalyst inactivates rapidly during the first two batches of 2Â h each, losing 50% or more of its activity. The inactivation becomes slower over the following longer batches of 24Â h. This pattern of rapid and slower phases of inactivation is similar to that observed in continuous reactors. However, in both acetonitrile and tetrahydrofuran, inactivation is somewhat faster over the first 4Â h of continuous operation than in the equivalent batch mode.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical Engineering Journal - Volume 24, Issue 1, 15 May 2005, Pages 11-15
Journal: Biochemical Engineering Journal - Volume 24, Issue 1, 15 May 2005, Pages 11-15
نویسندگان
João F. Amorim Fernandes, Morven McAlpine, Peter J. Halling,