کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10160714 254 2005 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Novel enzymatic route for kinetic resolution of (±)1,4-benzodioxan-2-carboxylic acid
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی بیو مهندسی (مهندسی زیستی)
پیش نمایش صفحه اول مقاله
Novel enzymatic route for kinetic resolution of (±)1,4-benzodioxan-2-carboxylic acid
چکیده انگلیسی
Ethyl 1,4-benzodioxan-2-carboxylate is used as an intermediate compound for the production of drug doxazosin mesylate. The title compound was kinetically resolved to get S-enantiomer of ethyl 1,4-benzodioxan 2-carboxylate in a simple lipase catalyzed transesterification reaction. Ethyl acetate was used as reaction medium as well as acyl donor. The influence of the enzyme source and time of reaction on the enantio selectivity of product were studied. Lipase from Candida antartica-B (Novozyme A/S) catalyzed transesterification reaction with good enantio selectivity towards S-enantiomer. The high enantiomeric ratio, E = 160, provided S-2 an acceptable chemical yield (50%) and enantiomeric excess (>95%).
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical Engineering Journal - Volume 27, Issue 1, 1 December 2005, Pages 66-71
نویسندگان
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