کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10162068 | 1114315 | 2015 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Three-Dimensional Printing of Drug-Eluting Implants: Preparation of an Antimicrobial Polylactide Feedstock Material
ترجمه فارسی عنوان
چاپ سه بعدی از ایمپلنت های درمانی مواد مخدر: تهیه یک ماده اولیه مواد پلی یکتیتی ضد میکروبی
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کلمات کلیدی
poly(lactic/glycolic) acid (PLGA or PLA)Controlled release - انتشار کنترل شدهExtrusion - اکستروژنPolymers - بسپار یا پلیمر Biomaterials - بیومتریال، بیومواد Drug delivery systems - سیستم های تحویل داروPolymeric drug delivery systems - سیستم های تحویل دارویی پلیمریantiinfectives - ضد عفونی کنندهSpectroscopy - طیفسنجیMicroscopy - میکروسکوپ یا ریزبین
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
چکیده انگلیسی
The aim of the present work was to investigate the potential of three-dimensional (3D) printing as a manufacturing method for products intended for personalized treatments by exploring the production of novel polylactide-based feedstock materials for 3D printing purposes. Nitrofurantoin (NF) and hydroxyapatite (HA) were successfully mixed and extruded with up to 30% drug load with and without addition of 5% HA in polylactide strands, which were subsequently 3D-printed into model disc geometries (10Â ÃÂ 2Â mm). X-ray powder diffraction analysis showed that NF maintained its anhydrate solid form during the processing. Release of NF from the disks was dependent on the drug loading in a concentration-dependent manner as a higher level of released drug was observed from disks with higher drug loads. Disks with 30% drug loading were able to prevent surface-associated and planktonic growth of Staphylococcus aureus over a period of 7Â days. At 10% drug loading, the disks did not inhibit planktonic growth, but still inhibited surface-associated growth. Elemental analysis indicated the presence of microdomains of solid drug supporting the observed slow and partial drug release. This work demonstrates the potential of custom-made, drug-loaded feedstock materials for 3D printing of pharmaceutical products for controlled release. © 2015 Wiley Periodicals, Inc. and the American Pharmacists Association.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 104, Issue 3, March 2015, Pages 1099-1107
Journal: Journal of Pharmaceutical Sciences - Volume 104, Issue 3, March 2015, Pages 1099-1107
نویسندگان
Jorrit Jeroen Water, Adam Bohr, Johan Boetker, Johanna Aho, Niklas Sandler, Hanne Mørck Nielsen, Jukka Rantanen,