کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10162075 | 1114315 | 2015 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A Pharmacokinetic Model for Quantifying the Effect of Vascular Permeability on the Choice of Drug Carrier: A Framework for Personalized Nanomedicine
ترجمه فارسی عنوان
یک مدل فارماکوکینتیک برای اندازه گیری اثر نفوذپذیری عروقی بر انتخاب حامل مواد مخدر: چارچوب شخصی سازی نانو مواد
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
Enhanced permeability and retention (EPR) effectParticle size - اندازه ذراتAnticancer drug delivery - تحویل دارو ضد سرطانCancer - سرطانChemotherapy - شیمیدرمانیPharmacokinetics/pharmacodynamics - فارماکوکینتیک / فارماکودینامیکNanoparticles - نانوذراتControlled release/delivery - کنترل انتشار / تحویل
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
چکیده انگلیسی
Drug carriers in the ~Â 100Â nm size range are of considerable interest in the field of cancer therapy because of their ability to passively accumulate in tumors. Tailoring the physicochemical properties of these carriers to individual patient requirements will help exploit their full therapeutic potential. Here, we present a pharmacokinetic model to explain how vascular physiology could be used to guide the optimal choice of specific formulation parameters. We find that in order to maximize the benefit-to-risk ratio, nanosystems should be confined to a specific particle size range. The optimal particle size range is dictated by the vascular pore size of not only the tumor tissue but also of the normal organs. Additionally, the duration of drug release is a key variable that can be used to maximize the therapeutic benefit of nanomedicine. Our model further suggests that the enhanced permeability and retention effect is not necessarily a universal outcome for every nanocarrier in every tumor model but will only be observed for nanoparticles of a specific size range. This optimal size range, in turn, is governed by the vascular physiology of the tumor and of non-target organs. © 2015 Wiley Periodicals, Inc. and the American Pharmacists Association.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 104, Issue 3, March 2015, Pages 1174-1186
Journal: Journal of Pharmaceutical Sciences - Volume 104, Issue 3, March 2015, Pages 1174-1186
نویسندگان
Ameya R. Kirtane, Ronald A. Siegel, Jayanth Panyam,