کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10162236 | 1114323 | 2015 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Pharmacokinetic Properties of Single and Repeated Injection of Liposomal Platelet Substitute in a Rat Model of Red Blood Cell Transfusion-Induced Dilutional Thrombocytopenia
ترجمه فارسی عنوان
خواص فارماکوکینتیک تزریق یک و چند بار از جایگزین ورید وریدی لیپوسوم در یک مدل موش صحرایی ترومبوسیتوپنی تخلیه شده توسط ترانسفوزیون سلول قرمز خون
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کلمات کلیدی
PEGylationdodecapeptideadenosine-diphosphate - آدنوزین دی فسفاتTransfusion - ترانسفوزیون یا انتقال خونclearance - ترخیص کالا از گمرکThrombocytopenia - ترومبوسیتوپنیPlatelet substitute - جایگزین پلاکتPharmacokinetics - فارماکوکینتیکLiposome - لیپوزوم هاAccelerated blood clearance phenomenon - پدیده پاکسازی خون سریع
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
چکیده انگلیسی
A preclinical study of dodecapeptide (400HHLGGAKQAGDV411) (H12)-(adenosine diphosphate, ADP)-liposomes for use as a synthetic platelet (PLT) substitute under conditions of red blood cell (RBC) transfusion-induced dilutional thrombocytopenia is limited to pharmacological effect. In this study, the pharmacokinetics of H12-(ADP)-liposomes in RBC transfusion-induced dilutional thrombocytopenic rats were evaluated. As evidenced by the use of 14C, 3H double-radiolabeled H12-(ADP)-liposomes in which the encapsulated ADP and liposomal membrane were labeled with 14C and 3H, respectively, the H12-(ADP)-liposomes remained intact in the blood circulation for up to 3Â h after injection, and were mainly distributed to the liver and spleen. The encapsulated ADP was mainly eliminated in the urine, whereas the outer membrane was mainly eliminated in the feces. These successive pharmacokinetic properties of the H12-(ADP)-liposomes in RBC transfusion-induced dilutional thrombocytopenic rats were similar to those in healthy rats, except for the shorter retention time in the circulation. When H12-(ADP)-liposomes were repeatedly injected into RBC transfusion-induced dilutional thrombocytopenic rats at intervals of 5 days at a dose of 10Â mg lipids/kg, the second dose of injected H12-(ADP)-liposomes were rapidly cleared from the circulation, namely, via the accelerated blood clearance phenomenon. These novel pharmacokinetic findings provide useful information for the further development of H12-(ADP)-liposomes as a PLT substitute.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 104, Issue 11, November 2015, Pages 3968-3976
Journal: Journal of Pharmaceutical Sciences - Volume 104, Issue 11, November 2015, Pages 3968-3976
نویسندگان
Mai Hashimoto, Kazuaki Taguchi, Shigeru Ogaki, Hiroshi Watanabe, Manabu Kinoshita, Kahoko Nishikawa, Shinji Takeoka, Yasuo Ikeda, Makoto Handa, Masaki Otagiri, Toru Maruyama,