کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10162268 | 1114324 | 2014 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
An Intravaginal Ring for the Sustained Delivery of Antibodies
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Human monoclonal antibodies (mAbs) based on IgG and IgA have shown promise as topical microbicide candidates to protect women from HIV infection. Application of mAbs has been limited, however, by the inability of vaginal gels and conventional intravaginal ring (IVR) designs, the predominant vaginal product formulations, to effectively deliver biomolecules in a coitally independent fashion with retention of bioactivity. We have developed a novel podâIVR platform that delivers ovine IgG (ovâIgG) as a model for IgG and IgA human mAbs. In vitro release of ovâIgG from the podâIVRs was sustained for 14 days. Facile control of release rate was achieved by changing the size of delivery channels in the ring structure, and the feasibility of ovâIgG delivery in the range 0.5-30Â mg dayâ1 from a 10âpod IVR was demonstrated. The activity of ovâIgG in podâIVR formulations was maintained as confirmed by ELISA binding assay. PodâIVRs delivering ovâIgG show promise for the effective sustained topical delivery of antibodyâbased microbicides. This significantly broadens the range of microbicides that can be delivered in a sustained fashion from IVRs and enables a new arsenal of topical biologic microbicide candidates beyond small molecule antiretrovirals. © 2014 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 103:3611-3620, 2014
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 103, Issue 11, November 2014, Pages 3611-3620
Journal: Journal of Pharmaceutical Sciences - Volume 103, Issue 11, November 2014, Pages 3611-3620
نویسندگان
Manjula Gunawardana, Marc M. Baum, Thomas J. Smith, John A. Moss,