کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10162398 | 1114328 | 2014 | 14 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The Influence of Feedstock and Process Variables on the Encapsulation of Drug Suspensions by SprayâDrying in Fast Drying Regime: The Case of Novel Antitubercular Drug-Palladium Complex Containing Polymeric Microparticles
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The purpose of this study was to address the effect of feedstock properties and process variables on the characteristics of antitubercular drug-palladium (Pd) containing poly(lactic) acid (PLA) microparticles (MP) obtained by sprayâdrying of noncolloidal particle dispersions in fast drying regime. Two different systems were compared: capreomycin-Pd (C-Pd) and ofloxacin-Pd (Ofx-Pd) dispersions in acetonitrile PLA solution. Particle size, dynamic light scattering, differential scanning calorimetry, SEM-energy dispersive Xâray, and spectrophotometric methods were used for MP characterization. C-Pdâloaded MP were optimized preliminarily by experimental design and compared with Ofx-Pdâloaded MP investigated in our previous work. Morphology of feedstock particles had a dominant role in determining MP morphology. The Charlesworth and Marshall theory was used to explain such behavior. The smaller and homogeneous C-Pd microparticulates favored MP inflation and buckling by forming a thick and nonporous shell. A percolation effect was proposed for the larger and irregular Ofx-Pd particles that produced smaller MP with a more porous shell. Increasing feedstock concentration led to higher particle loss. A tentative descriptive scheme of MP formation according to feedstock particle arrangement was proposed. This work suggested that sprayâdrying of drug dispersions should carefully consider the morphology of feedstock particles as a major parameter influencing final MP properties. © 2014 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 103:1255-1268, 2014
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 103, Issue 4, April 2014, Pages 1255-1268
Journal: Journal of Pharmaceutical Sciences - Volume 103, Issue 4, April 2014, Pages 1255-1268
نویسندگان
Stefano Giovagnoli, Francesco Palazzo, Alessandro Di Michele, Aurelie Schoubben, Paolo Blasi, Maurizio Ricci,