کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10162512 1114333 2013 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Mebendazole Mesylate Monohydrate: A New Route to Improve the Solubility of Mebendazole Polymorphs
ترجمه فارسی عنوان
ماندندازول مسیلات مونوهیدرات: راه جدید برای بهبود حلالیت مگنازول پلیمورف
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی اکتشاف دارویی
چکیده انگلیسی
Mebendazole mesylate monohydrate, a new stable salt of mebendazole (MBZ), has been synthesized and fully characterized. It was obtained from recrystallization of MBZ forms A, B, or C in diverse solvents with the addition of methyl sulfonic acid solution. The crystal packing is first organized as a two-dimensional array consisting of rows of alternating MBZ molecules linked to columns of mesylate ions by hydrogen bonds. The three-dimensional structure is further developed by classical intermolecular interactions involving water molecules. In addition, nonclassical contacts are also found. The vibrational behavior is consistent with the crystal structure, the most important functional groups showing shifts to lower or higher frequencies in relation to the MBZ polymorphs. Thermal analysis indicates that the compound is stable up to 50°C. Decomposition occurs in five steps. Solubility studies show that the title compound presents a significant higher performance than polymorph C.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 102, Issue 10, October 2013, Pages 3528-3538
نویسندگان
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