کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10162627 | 1114335 | 2014 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Pharmacokinetics in Rats of a Long-Acting Human Parathyroid Hormone-Collagen Binding Domain Peptide Construct
ترجمه فارسی عنوان
فارماکوکینتیک در موش صحرایی از ساختار پپتید دامنه هورمون-کلاژن هورمونی پاراتیروئید انسانی
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کلمات کلیدی
CBD, collagen-binding domainAIC, akaike information criterion - AIC، معیار اطلاعات akaikePopulation pharmacokinetics - Farmakokinetics جمعیتCollagen binding - اتصال کلاژنPeptide delivery - تحویل پپتیدteriparatide - تریپاراتیPreclinical pharmacokinetics - فارماکوکینتیک پیشکلامیpharmacokinetic/pharmacodynamic models - مدل های فارماکوکینتیک / فارماکودینامیکOsteoporosis - پوکی استخوانPeptides - پپتیدها
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
چکیده انگلیسی
The pharmacokinetics of a hybrid peptide consisting of the N-terminal biologically active region of human parathyroid hormone (PTH) linked to a collagen-binding domain (CBD) were evaluated in female Sprague-Dawley rats. The peptide, PTH-CBD, consists of the first 33 amino acids of PTH linked as an extension of the amino acid chain to the CBD peptide derived from ColH collagenase of Clostridium histolyticum. Serum concentrations arising from single dose administration by the subcutaneous and intravenous routes were compared with those measured following route-specific mole equivalent doses of PTH(1-34). Population-based modeling demonstrated similar systemic absorption kinetics and bioavailability for both peptides. Exposure to PTH-CBD was sixfold higher because of a systemic clearance of approximately 20% relative to PTH(1-34); however, these kinetics were consistent with more than 95% of a dose being eliminated from serum within 24Â h. Results obtained support continued investigation of PTH-CBD as a bone-targeted anabolic agent for the treatment of postmenopausal osteoporosis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 103, Issue 2, February 2014, Pages 768-775
Journal: Journal of Pharmaceutical Sciences - Volume 103, Issue 2, February 2014, Pages 768-775
نویسندگان
Robert Jr., V.U. Christopher, Joshua Sakon, Ranjitha Katikaneni, Robert Gensure, Tulasi Ponnapakkam,